| 1 | Sat Sep 2 | vs Wofford | W45-7 | 1-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 2 | Sat Sep 9 | vsCincinnati | L21-27 | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sat Sep 16 | atWest Virginia | L6-17 | 1-2 | .333 | Milan Puskar Stadium · Morgantown, WV |
| 4 | Sat Sep 23 | vs#17UNC | L24-41 | 1-3 | .250 | Acrisure Stadium · Pittsburgh, PA |
| 5 | Sat Sep 30 | atVirginia Tech | L21-38 | 1-4 | .200 | Lane Stadium · Blacksburg, VA |
| 6 | Sat Oct 14 | vs#14Louisville | W38-21 | 2-4 | .333 | Acrisure Stadium · Pittsburgh, PA |
| 7 | Sat Oct 21 | atWake Forest | L17-21 | 2-5 | .286 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 8 | Sat Oct 28 | at#14Notre Dame | L7-58 | 2-6 | .250 | Notre Dame Stadium · Notre Dame, IN |
| 9 | Sat Nov 4 | vs#4Florida St | L7-24 | 2-7 | .222 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sat Nov 11 | atSyracuse | L13-28 | 2-8 | .200 | JMA Wireless Dome · Syracuse, NY |
| 11 | Thu Nov 16 | vsBoston College | W24-16 | 3-8 | .273 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Sat Nov 25 | atDuke | L19-30 | 3-9 | .250 | Wallace Wade Stadium · Durham, NC |
