| 1 | Mon Sep 5 | at Georgia Tech | W41-10 | 1-0 | 1.000 | Bobby Dodd Stadium · Atlanta, GA |
| 2 | Sat Sep 10 | vsFurman | W35-12 | 2-0 | 1.000 | Memorial Stadium · Clemson, SC |
| 3 | Sat Sep 17 | vsLouisiana Tech | W48-20 | 3-0 | 1.000 | Memorial Stadium · Clemson, SC |
| 4 | Sat Sep 24 | at#21Wake Forest | W51-45 (2OT) | 4-0 | 1.000 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 5 | Sat Oct 1 | vs#10NC State | W30-20 | 5-0 | 1.000 | Memorial Stadium · Clemson, SC |
| 6 | Sat Oct 8 | atBoston College | W31-3 | 6-0 | 1.000 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| 7 | Sat Oct 15 | atFlorida St | W34-28 | 7-0 | 1.000 | Doak Campbell Stadium · Tallahassee, FL |
| 8 | Sat Oct 22 | vs#14Syracuse | W27-21 | 8-0 | 1.000 | Memorial Stadium · Clemson, SC |
| 9 | Sat Nov 5 | atNotre Dame | L14-35 | 8-1 | .889 | Notre Dame Stadium · Notre Dame, IN |
| 10 | Sat Nov 12 | vsLouisville | W31-16 | 9-1 | .900 | Memorial Stadium · Clemson, SC |
| 11 | Sat Nov 19 | vsMiami | W40-10 | 10-1 | .909 | Memorial Stadium · Clemson, SC |
| 12 | Sat Nov 26 | vsSouth Carolina | L30-31 | 10-2 | .833 | Memorial Stadium · Clemson, SC |
| 13 | Sat Dec 3 | at#23UNC | W39-10 | 11-2 | .846 | Kenan Stadium · Chapel Hill, NC |
| BOWLS | Fri Dec 30 | vs#6Tennessee | L14-31 | 11-3 | .786 | Memorial Stadium · Clemson, SC |
