| 1 | Thu Sep 1 | vs Ball State | W59-10 | 1-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 2 | Sat Sep 10 | at#17Pitt | W34-27 (OT) | 2-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sat Sep 17 | vsAkron | W63-6 | 3-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 4 | Sat Sep 24 | vs#20Florida | W38-33 | 4-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 5 | Sat Oct 8 | atLSU | W40-13 | 5-0 | 1.000 | Tiger Stadium · Baton Rouge, LA |
| 6 | Sat Oct 15 | vs#3Alabama | W52-49 | 6-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 7 | Sat Oct 22 | vsUT Martin | W65-24 | 7-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 8 | Sat Oct 29 | vs#19Kentucky | W44-6 | 8-0 | 1.000 | Neyland Stadium · Knoxville, TN |
| 9 | Sat Nov 5 | at#3Georgia | L13-27 | 8-1 | .889 | Sanford Stadium · Athens, GA |
| 10 | Sat Nov 12 | vsMissouri | W66-24 | 9-1 | .900 | Neyland Stadium · Knoxville, TN |
| 11 | Sat Nov 19 | atSouth Carolina | L38-63 | 9-2 | .818 | Williams-Brice Stadium · Columbia, SC |
| 12 | Sat Nov 26 | atVanderbilt | W56-0 | 10-2 | .833 | FirstBank Stadium · Nashville, TN |
| BOWLS | Fri Dec 30 | at#7Clemson | W31-14 | 11-2 | .846 | Memorial Stadium · Clemson, SC |
