| 1 | Sat Aug 30 | vs Syracuse | W45-26 | 1-0 · #24 | 1.000 | Neyland Stadium · Knoxville, TN |
| 2 | Sat Sep 6 | vsETSU | W72-17 | 2-0 · #22 | 1.000 | Neyland Stadium · Knoxville, TN |
| 3 | Sat Sep 13 | vs6Georgia | L41-44 (OT) | 2-1 · #15 | .667 | Neyland Stadium · Knoxville, TN |
| 4 | Sat Sep 20 | vsUAB | W56-24 | 3-1 · #15 | .750 | Neyland Stadium · Knoxville, TN |
| 5 | Sat Sep 27 | atMississippi St | W41-34 (OT) | 4-1 · #15 | .800 | Davis Wade Stadium · Starkville, MS |
| 6 | Sat Oct 11 | vsArkansas | W34-31 | 5-1 · #12 | .833 | Neyland Stadium · Knoxville, TN |
| 7 | Sat Oct 18 | at6Alabama | L20-37 | 5-2 · #11 | .714 | Bryant-Denny Stadium · Tuscaloosa, AL |
| 8 | Sat Oct 25 | atKentucky | W56-34 | 6-2 · #17 | .750 | Kroger Field · Lexington, KY |
| 9 | Sat Nov 1 | vs18Oklahoma | L27-33 | 6-3 · #14 | .667 | Neyland Stadium · Knoxville, TN |
| 10 | Sat Nov 15 | vsNew Mexico St | W42-9 | 7-3 · #23 | .700 | Neyland Stadium · Knoxville, TN |
| 11 | Sat Nov 22 | atFlorida | W31-11 | 8-3 · #20 | .727 | Ben Hill Griffin Stadium · Gainesville, FL |
| 12 | Sat Nov 29 | vs14Vanderbilt | L24-45 | 8-4 · #19 | .667 | Neyland Stadium · Knoxville, TN |
| BOWLS | Tue Dec 30 | atIllinois | L28-30 | 8-5 | .615 | Alumni Memorial Field at Foster Stadium · Lexington, VA |
