| 1 | Fri Aug 29 | at Wake Forest | L9-10 | 0-1 | .000 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 2 | Sat Sep 6 | at #23Indiana | L9-56 | 0-2 | .000 | Memorial Stadium · Bloomington, IN |
| 3 | Sat Sep 13 | vs Merrimack | W27-13 | 1-2 | .333 | Fifth Third Stadium |
| 4 | Sat Sep 20 | vs Arkansas St | W28-21 | 2-2 | .500 | Fifth Third Stadium |
| 5 | Sat Sep 27 | vs MTSU | W24-16 | 3-2 | .600 | Fifth Third Stadium |
| 6 | Thu Oct 9 | vs Louisiana Tech | W35-7 | 4-2 | .667 | Fifth Third Stadium |
| 7 | Tue Oct 21 | at FIU | W45-26 | 5-2 | .714 | Riccardo Silva Stadium · Miami, FL |
| 8 | Tue Oct 28 | vs UTEP | W33-20 | 6-2 | .750 | Fifth Third Stadium |
| 9 | Sat Nov 8 | at New Mexico St | W24-21 | 7-2 | .778 | Aggie Memorial Stadium · Las Cruces, NM |
| 10 | Sat Nov 15 | at J'Ville St | L26-35 | 7-3 | .700 | Burgess-Snow Field · Jacksonville, AL |
| 11 | Sat Nov 22 | vs Missouri St | W41-34 | 8-3 | .727 | Fifth Third Stadium |
| 12 | Sat Nov 29 | at Liberty | W48-42 (2OT) | 9-3 | .750 | Williams Stadium (VA) · Lynchburg, VA |