| 1 | Mon Sep 6 | at Ole Miss | L24-43 | 0-1 | .000 | Vaught-Hemingway Stadium · Oxford, MS |
| 2 | Sat Sep 11 | vsE Kentucky | W30-3 | 1-1 | .500 | Cardinal Stadium · Louisville, KY |
| 3 | Fri Sep 17 | vsUCF | W42-35 | 2-1 | .667 | Cardinal Stadium · Louisville, KY |
| 4 | Sat Sep 25 | atFlorida St | W31-23 | 3-1 | .750 | Doak Campbell Stadium · Tallahassee, FL |
| 5 | Sat Oct 2 | at#24Wake Forest | L34-37 | 3-2 | .600 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 6 | Sat Oct 9 | vsVirginia | L33-34 | 3-3 | .500 | Cardinal Stadium · Louisville, KY |
| 7 | Sat Oct 23 | vsBoston College | W28-14 | 4-3 | .571 | Cardinal Stadium · Louisville, KY |
| 8 | Sat Oct 30 | atNC State | L13-28 | 4-4 | .500 | Carter-Finley Stadium · Raleigh, NC |
| 9 | Sat Nov 6 | vsClemson | L24-30 | 4-5 | .444 | Cardinal Stadium · Louisville, KY |
| 10 | Sat Nov 13 | vsSyracuse | W41-3 | 5-5 | .500 | Cardinal Stadium · Louisville, KY |
| 11 | Thu Nov 18 | atDuke | W62-22 | 6-5 | .545 | Wallace Wade Stadium · Durham, NC |
| 12 | Sat Nov 27 | vsKentucky | L21-52 | 6-6 | .500 | Cardinal Stadium · Louisville, KY |
| BOWLS | Tue Dec 28 | vsAir Force | L28-31 | 6-7 | .462 | Cardinal Stadium · Louisville, KY |
