| 1 | Sat Aug 30 | vs E Kentucky | W51-17 | 1-0 | 1.000 | Cardinal Stadium · Louisville, KY |
| 2 | Fri Sep 5 | vsJMU | W28-14 | 2-0 | 1.000 | Cardinal Stadium · Louisville, KY |
| 3 | Sat Sep 20 | vsBowling Green | W40-17 | 3-0 | 1.000 | Cardinal Stadium · Louisville, KY |
| 4 | Sat Sep 27 | atPitt | W34-27 | 4-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 5 | Sat Oct 4 | vs#24Virginia | L27-30 (OT) | 4-1 | .800 | Cardinal Stadium · Louisville, KY |
| 6 | Fri Oct 17 | at#2Miami | W24-21 | 5-1 | .833 | Hard Rock Stadium · Miami Gardens, FL |
| 7 | Sat Oct 25 | vsBoston College | W38-24 | 6-1 | .857 | Cardinal Stadium · Louisville, KY |
| 8 | Sat Nov 1 | atVirginia Tech | W28-16 | 7-1 | .875 | Lane Stadium · Blacksburg, VA |
| 9 | Sat Nov 8 | vsCalifornia | L26-29 (OT) | 7-2 | .778 | Cardinal Stadium · Louisville, KY |
