| 1 | Sat Sep 2 | vs Colgate | W65-0 | 1-0 | 1.000 | JMA Wireless Dome · Syracuse, NY |
| 2 | Sat Sep 9 | vsW Michigan | W48-7 | 2-0 | 1.000 | JMA Wireless Dome · Syracuse, NY |
| 3 | Sat Sep 16 | atPurdue | W35-20 | 3-0 | 1.000 | Ross-Ade Stadium · West Lafayette, IN |
| 4 | Sat Sep 23 | vsArmy | W29-16 | 4-0 | 1.000 | JMA Wireless Dome · Syracuse, NY |
| 5 | Sat Sep 30 | vsClemson | L14-31 | 4-1 | .800 | JMA Wireless Dome · Syracuse, NY |
| 6 | Sat Oct 7 | at#14UNC | L7-40 | 4-2 | .667 | Kenan Stadium · Chapel Hill, NC |
| 7 | Sat Oct 14 | at#4Florida St | L3-41 | 4-3 | .571 | Doak Campbell Stadium · Tallahassee, FL |
| 8 | Thu Oct 26 | atVirginia Tech | L10-38 | 4-4 | .500 | Lane Stadium · Blacksburg, VA |
| 9 | Fri Nov 3 | vsBoston College | L10-17 | 4-5 | .444 | JMA Wireless Dome · Syracuse, NY |
| 10 | Sat Nov 11 | vsPitt | W28-13 | 5-5 | .500 | JMA Wireless Dome · Syracuse, NY |
| 11 | Sat Nov 18 | atGeorgia Tech | L22-31 | 5-6 | .455 | Bobby Dodd Stadium · Atlanta, GA |
| 12 | Sat Nov 25 | vsWake Forest | W35-31 | 6-6 | .500 | JMA Wireless Dome · Syracuse, NY |
| BOWLS | Thu Dec 21 | vsSouth Florida | L0-45 | 6-7 | .462 | JMA Wireless Dome · Syracuse, NY |
