| 1 | Sat Aug 30 | vs Ball State | W31-0 | 1-0 | 1.000 | Ross-Ade Stadium · West Lafayette, IN |
| 2 | Sat Sep 6 | vsS Illinois | W34-17 | 2-0 | 1.000 | Ross-Ade Stadium · West Lafayette, IN |
| 3 | Sat Sep 13 | vsUSC | L17-33 | 2-1 | .667 | Ross-Ade Stadium · West Lafayette, IN |
| 4 | Sat Sep 20 | at#24Notre Dame | L30-56 | 2-2 | .500 | Notre Dame Stadium · Notre Dame, IN |
| 5 | Sat Oct 4 | vs#22Illinois | L27-43 | 2-3 | .400 | Ross-Ade Stadium · West Lafayette, IN |
| 6 | Sat Oct 11 | atMinnesota | L20-27 | 2-4 | .333 | Huntington Bank Stadium · Minneapolis, MN |
| 7 | Sat Oct 18 | atNorthwestern | L0-19 | 2-5 | .286 | Ryan Field · Evanston, IL |
| 8 | Sat Oct 25 | vsRutgers | L24-27 | 2-6 | .250 | Ross-Ade Stadium · West Lafayette, IN |
| 9 | Sat Nov 1 | at#21Michigan | L16-21 | 2-7 | .222 | Michigan Stadium · Ann Arbor, MI |
| 10 | Sat Nov 8 | vs#1Ohio State | L10-34 | 2-8 | .200 | Ross-Ade Stadium · West Lafayette, IN |
| 11 | Sat Nov 15 | atWashington | L13-49 | 2-9 | .182 | Husky Stadium · Seattle, WA |
| 12 | Fri Nov 28 | vs#2Indiana | L3-56 | 2-10 | .167 | Ross-Ade Stadium · West Lafayette, IN |
