| 1 | Sat Aug 31 | vs Indiana St | W49-0 | 1-0 | 1.000 | Ross-Ade Stadium · West Lafayette, IN |
| 3 | Sat Sep 14 | vs #18Notre Dame | L7-66 | 1-1 | .500 | Ross-Ade Stadium · West Lafayette, IN |
| 4 | Sat Sep 21 | at Oregon St | L21-38 | 1-2 | .333 | Reser Stadium · Corvallis, OR |
| 5 | Sat Sep 28 | vs Nebraska | L10-28 | 1-3 | .250 | Ross-Ade Stadium · West Lafayette, IN |
| 6 | Sat Oct 5 | at Wisconsin | L6-52 | 1-4 | .200 | Camp Randall Stadium · Madison, WI |
| 7 | Sat Oct 12 | at #23Illinois | L49-50 (OT) | 1-5 | .167 | Alumni Memorial Field at Foster Stadium · Lexington, VA |
| 8 | Fri Oct 18 | vs #2Oregon | L0-35 | 1-6 | .143 | Ross-Ade Stadium · West Lafayette, IN |
| 10 | Sat Nov 2 | vs Northwestern | L20-26 (OT) | 1-7 | .125 | Ross-Ade Stadium · West Lafayette, IN |
| 11 | Sat Nov 9 | at #2Ohio State | L0-45 | 1-8 | .111 | Ohio Stadium · Columbus, OH |
| 12 | Sat Nov 16 | vs #4Penn State | L10-49 | 1-9 | .100 | Ross-Ade Stadium · West Lafayette, IN |
| 13 | Fri Nov 22 | at Michigan St | L17-24 | 1-10 | .091 | Spartan Stadium · East Lansing, MI |
| 14 | Sat Nov 30 | at #10Indiana | L0-66 | 1-11 | .083 | Memorial Stadium · Bloomington, IN |
