| 1 | Thu Sep 1 | vs Penn State | L31-35 | 0-1 | .000 | Ross-Ade Stadium · West Lafayette, IN |
| 2 | Sat Sep 10 | vsIndiana St | W56-0 | 1-1 | .500 | Ross-Ade Stadium · West Lafayette, IN |
| 3 | Sat Sep 17 | atSyracuse | L29-32 | 1-2 | .333 | JMA Wireless Dome · Syracuse, NY |
| 4 | Sat Sep 24 | vsFAU | W28-26 | 2-2 | .500 | Ross-Ade Stadium · West Lafayette, IN |
| 5 | Sat Oct 1 | at#21Minnesota | W20-10 | 3-2 | .600 | Huntington Bank Stadium · Minneapolis, MN |
| 6 | Sat Oct 8 | atMaryland | W31-29 | 4-2 | .667 | SECU Stadium · College Park, MD |
| 7 | Sat Oct 15 | vsNebraska | W43-37 | 5-2 | .714 | Ross-Ade Stadium · West Lafayette, IN |
| 8 | Sat Oct 22 | atWisconsin | L24-35 | 5-3 | .625 | Camp Randall Stadium · Madison, WI |
| 9 | Sat Nov 5 | vsIowa | L3-24 | 5-4 | .556 | Ross-Ade Stadium · West Lafayette, IN |
| 10 | Sat Nov 12 | at#21Illinois | W31-24 | 6-4 | .600 | Alumni Memorial Field at Foster Stadium · Lexington, VA |
| 11 | Sat Nov 19 | vsNorthwestern | W17-9 | 7-4 | .636 | Ross-Ade Stadium · West Lafayette, IN |
| 12 | Sat Nov 26 | atIndiana | W30-16 | 8-4 | .667 | Memorial Stadium · Bloomington, IN |
| 13 | Sat Dec 3 | at#2Michigan | L22-43 | 8-5 | .615 | Michigan Stadium · Ann Arbor, MI |
| BOWLS | Mon Jan 2 | vs#17LSU | L7-63 | 8-6 | .571 | Ross-Ade Stadium · West Lafayette, IN |
