| 1 | Fri Aug 30 | at Nevada | L31-34 | 0-1 | .000 | Mackay Stadium · Reno, NV |
| 2 | Sat Sep 7 | vsVanderbilt | W42-24 | 1-1 | .500 | Ross-Ade Stadium · West Lafayette, IN |
| 3 | Sat Sep 14 | vsTCU | L13-34 | 1-2 | .333 | Ross-Ade Stadium · West Lafayette, IN |
| 4 | Sat Sep 28 | vsMinnesota | L31-38 | 1-3 | .250 | Ross-Ade Stadium · West Lafayette, IN |
| 5 | Sat Oct 5 | at#12Penn State | L7-35 | 1-4 | .200 | Beaver Stadium · University Park, PA |
| 6 | Sat Oct 12 | vsMaryland | W40-14 | 2-4 | .333 | Ross-Ade Stadium · West Lafayette, IN |
| 7 | Sat Oct 19 | at#23Iowa | L20-26 | 2-5 | .286 | Kinnick Stadium · Iowa City, IA |
| 8 | Sat Oct 26 | vsIllinois | L6-24 | 2-6 | .250 | Ross-Ade Stadium · West Lafayette, IN |
| 9 | Sat Nov 2 | vsNebraska | W31-27 | 3-6 | .333 | Ross-Ade Stadium · West Lafayette, IN |
| 10 | Sat Nov 9 | atNorthwestern | W24-22 | 4-6 | .400 | Ryan Field · Evanston, IL |
| 11 | Sat Nov 23 | at#12Wisconsin | L24-45 | 4-7 | .364 | Camp Randall Stadium · Madison, WI |
| 12 | Sat Nov 30 | vsIndiana | L41-44 (2OT) | 4-8 | .333 | Ross-Ade Stadium · West Lafayette, IN |
