| 1 | Sat Sep 2 | vs Fresno St | L35-39 | 0-1 | .000 | Ross-Ade Stadium · West Lafayette, IN |
| 2 | Sat Sep 9 | atVirginia Tech | W24-17 | 1-1 | .500 | Lane Stadium · Blacksburg, VA |
| 3 | Sat Sep 16 | vsSyracuse | L20-35 | 1-2 | .333 | Ross-Ade Stadium · West Lafayette, IN |
| 4 | Fri Sep 22 | vsWisconsin | L17-38 | 1-3 | .250 | Ross-Ade Stadium · West Lafayette, IN |
| 5 | Sat Sep 30 | vsIllinois | W44-19 | 2-3 | .400 | Ross-Ade Stadium · West Lafayette, IN |
| 6 | Sat Oct 7 | atIowa | L14-20 | 2-4 | .333 | Kinnick Stadium · Iowa City, IA |
| 7 | Sat Oct 14 | vs#3Ohio State | L7-41 | 2-5 | .286 | Ross-Ade Stadium · West Lafayette, IN |
| 8 | Sat Oct 28 | atNebraska | L14-31 | 2-6 | .250 | Memorial Stadium · Lincoln, NE |
| 9 | Sat Nov 4 | at#3Michigan | L13-41 | 2-7 | .222 | Michigan Stadium · Ann Arbor, MI |
| 10 | Sat Nov 11 | vsMinnesota | W49-30 | 3-7 | .300 | Ross-Ade Stadium · West Lafayette, IN |
| 11 | Sat Nov 18 | atNorthwestern | L15-23 | 3-8 | .273 | Ryan Field · Evanston, IL |
| 12 | Sat Nov 25 | vsIndiana | W35-31 | 4-8 | .333 | Ross-Ade Stadium · West Lafayette, IN |
