| 1 | Sat Sep 12 | vs Duke | W27-13 | 1-0 | 1.000 | Notre Dame Stadium · Notre Dame, IN |
| 2 | Sat Sep 19 | vsSouth Florida | W52-0 | 2-0 | 1.000 | Notre Dame Stadium · Notre Dame, IN |
| 3 | Sat Sep 26 | atWake Forest | PPD | 10-2 | .833 | Allegacy Federal Credit Union Stadium · Winston-Salem, NC |
| 4 | Sat Oct 10 | vsFlorida St | W42-26 | 3-0 | 1.000 | Notre Dame Stadium · Notre Dame, IN |
| 5 | Sat Oct 17 | vsLouisville | W12-7 | 4-0 | 1.000 | Notre Dame Stadium · Notre Dame, IN |
| 6 | Sat Oct 24 | atPitt | W45-3 | 5-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 7 | Sat Oct 31 | atGeorgia Tech | W31-13 | 6-0 | 1.000 | Bobby Dodd Stadium · Atlanta, GA |
| 8 | Sat Nov 7 | vs#1Clemson | W47-40 (2OT) | 7-0 | 1.000 | Notre Dame Stadium · Notre Dame, IN |
| 9 | Sat Nov 14 | atBoston College | W45-31 | 8-0 | 1.000 | Alumni Stadium (Chestnut Hill, MA) · Chestnut Hill, MA |
| 10 | Fri Nov 27 | at#19UNC | W31-17 | 9-0 | 1.000 | Kenan Stadium · Chapel Hill, NC |
| 11 | Sat Dec 5 | vsSyracuse | W45-21 | 10-0 | 1.000 | Notre Dame Stadium · Notre Dame, IN |
| 12 | Sat Dec 19 | vs#3Clemson | L10-34 | 10-1 | .909 | Notre Dame Stadium · Notre Dame, IN |
| BOWLS | Fri Jan 1 | at#1Alabama | L14-31 | 10-2 | .833 | Bryant-Denny Stadium · Tuscaloosa, AL |
