| 1 | Sat Sep 3 | at #2Ohio State | L10-21 | 0-1 | .000 | Ohio Stadium · Columbus, OH |
| 2 | Sat Sep 10 | vsMarshall | L21-26 | 0-2 | .000 | Notre Dame Stadium · Notre Dame, IN |
| 3 | Sat Sep 17 | vsCalifornia | W24-17 | 1-2 | .333 | Notre Dame Stadium · Notre Dame, IN |
| 4 | Sat Sep 24 | atUNC | W45-32 | 2-2 | .500 | Kenan Stadium · Chapel Hill, NC |
| 5 | Sat Oct 8 | vsBYU | W28-20 | 3-2 | .600 | Notre Dame Stadium · Notre Dame, IN |
| 6 | Sat Oct 15 | vsStanford | L14-16 | 3-3 | .500 | Notre Dame Stadium · Notre Dame, IN |
| 7 | Sat Oct 22 | vsUNLV | W44-21 | 4-3 | .571 | Notre Dame Stadium · Notre Dame, IN |
| 8 | Sat Oct 29 | at#16Syracuse | W41-24 | 5-3 | .625 | JMA Wireless Dome · Syracuse, NY |
| 9 | Sat Nov 5 | vs#4Clemson | W35-14 | 6-3 | .667 | Notre Dame Stadium · Notre Dame, IN |
| 10 | Sat Nov 12 | atNavy | W35-32 | 7-3 | .700 | Navy-Marine Corps Memorial Stadium · Annapolis, MD |
| 11 | Sat Nov 19 | vsBoston College | W44-0 | 8-3 | .727 | Notre Dame Stadium · Notre Dame, IN |
| 12 | Sat Nov 26 | at#6USC | L27-38 | 8-4 | .667 | Los Angeles Memorial Coliseum · Los Angeles, CA |
| BOWLS | Fri Dec 30 | atSouth Carolina | W45-38 | 9-4 | .692 | Williams-Brice Stadium · Columbia, SC |
