| 1 | Thu Aug 28 | vs SF Austin | W27-0 | 1-0 | 1.000 | Robertson Stadium · Houston, TX |
| 2 | Sat Sep 6 | atRice | W35-9 | 2-0 | 1.000 | Rice Stadium · Houston, TX |
| 3 | Fri Sep 12 | vsColorado | W36-20 | 3-0 | 1.000 | Robertson Stadium · Houston, TX |
| 4 | Fri Sep 26 | atOregon St | W27-24 (OT) | 4-0 | 1.000 | Reser Stadium · Corvallis, OR |
| 5 | Sat Oct 4 | vs#11Texas Tech | L11-35 | 4-1 | .800 | Robertson Stadium · Houston, TX |
| 6 | Sat Oct 11 | atOklahoma St | W39-17 | 5-1 | .833 | Boone Pickens Stadium · Stillwater, OK |
| 7 | Sat Oct 18 | vsArizona | W31-28 | 6-1 | .857 | Robertson Stadium · Houston, TX |
| 8 | Sat Oct 25 | at#24Arizona St | W24-16 | 7-1 | .875 | Mountain America Stadium · Tempe, AZ |
| 9 | Sat Nov 1 | vsWest Virginia | L35-45 | 7-2 | .778 | Robertson Stadium · Houston, TX |
| 10 | Fri Nov 7 | atUCF | W30-27 | 8-2 | .800 | FBC Mortgage Stadium · Orlando, FL |
