| 1 | Thu Sep 3 | vs Rice | PPD | 3-5 | .375 | Robertson Stadium · Houston, TX |
| 2 | Sat Sep 19 | atBaylor | PPD | 3-5 | .375 | Floyd Casey Stadium · Waco, TX |
| 3 | Sat Sep 26 | vsNorth Texas | PPD | 3-5 | .375 | Robertson Stadium · Houston, TX |
| 4 | Thu Oct 8 | vsTulane | W49-31 | 1-0 | 1.000 | Robertson Stadium · Houston, TX |
| 5 | Fri Oct 16 | vs#14BYU | L26-43 | 1-1 | .500 | Robertson Stadium · Houston, TX |
| 6 | Sat Oct 24 | atNavy | W37-21 | 2-1 | .667 | Navy-Marine Corps Memorial Stadium · Annapolis, MD |
| 7 | Sat Oct 31 | vsUCF | L21-44 | 2-2 | .500 | Robertson Stadium · Houston, TX |
| 8 | Sat Nov 7 | at#6Cincinnati | L10-38 | 2-3 | .400 | Nippert Stadium · Cincinnati, OH |
| 9 | Sat Nov 14 | vsSouth Florida | W56-21 | 3-3 | .500 | Robertson Stadium · Houston, TX |
| 10 | Sat Nov 21 | atSMU | PPD | 3-5 | .375 | Gerald J. Ford Stadium · Dallas, TX |
| 11 | Sat Nov 28 | vs#25Tulsa | PPD | 3-5 | .375 | Robertson Stadium · Houston, TX |
| 12 | Sat Dec 5 | atSMU | PPD | 3-5 | .375 | Gerald J. Ford Stadium · Dallas, TX |
| 13 | Sat Dec 12 | atMemphis | L27-30 | 3-4 | .429 | Simmons Bank Liberty Stadium · Memphis, TN |
| BOWLS | Thu Dec 24 | vsHawai'i | L14-28 | 3-5 | .375 | Robertson Stadium · Houston, TX |
