| 1 | Sun Sep 1 | at #4Oklahoma | L31-49 | 0-1 | .000 | Memorial Stadium · Norman, OK |
| 2 | Sat Sep 7 | vsPrairie View | W37-17 | 1-1 | .500 | Robertson Stadium · Houston, TX |
| 3 | Fri Sep 13 | vs#20Washington St | L24-31 | 1-2 | .333 | Robertson Stadium · Houston, TX |
| 4 | Thu Sep 19 | atTulane | L31-38 | 1-3 | .250 | Yulman Stadium · New Orleans, LA |
| 5 | Sat Sep 28 | atNorth Texas | W46-25 | 2-3 | .400 | DATCU Stadium · Denton, TX |
| 6 | Sat Oct 12 | vs#25Cincinnati | L23-38 | 2-4 | .333 | Robertson Stadium · Houston, TX |
| 7 | Sat Oct 19 | atUConn | W24-17 | 3-4 | .429 | Pratt & Whitney Stadium · East Hartford, CT |
| 8 | Thu Oct 24 | vs#16SMU | L31-34 | 3-5 | .375 | Robertson Stadium · Houston, TX |
| 9 | Sat Nov 2 | atUCF | L29-44 | 3-6 | .333 | FBC Mortgage Stadium · Orlando, FL |
| 10 | Sat Nov 16 | vs#18Memphis | L27-45 | 3-7 | .300 | Robertson Stadium · Houston, TX |
| 11 | Sat Nov 23 | atTulsa | W24-14 | 4-7 | .364 | Chapman Stadium · Tulsa, OK |
| 12 | Sat Nov 30 | vsNavy | L41-56 | 4-8 | .333 | Robertson Stadium · Houston, TX |
