| 1 | Sat Sep 2 | at Indiana | W23-3 | 1-0 | 1.000 | Memorial Stadium · Bloomington, IN |
| 2 | Sat Sep 9 | vsYoungstown St | W35-7 | 2-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 3 | Sat Sep 16 | vsWestern KY | W63-10 | 3-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 4 | Sat Sep 23 | at#9Notre Dame | W17-14 | 4-0 | 1.000 | Notre Dame Stadium · Notre Dame, IN |
| 5 | Sat Oct 7 | vsMaryland | W37-17 | 5-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 6 | Sat Oct 14 | atPurdue | W41-7 | 6-0 | 1.000 | Ross-Ade Stadium · West Lafayette, IN |
| 7 | Sat Oct 21 | vs#7Penn State | W20-12 | 7-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 8 | Sat Oct 28 | atWisconsin | W24-10 | 8-0 | 1.000 | Camp Randall Stadium · Madison, WI |
| 9 | Sat Nov 4 | atRutgers | W35-16 | 9-0 | 1.000 | HighPoint.com Stadium · Piscataway, NJ |
| 10 | Sat Nov 11 | vsMichigan St | W38-3 | 10-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 11 | Sat Nov 18 | vsMinnesota | W37-3 | 11-0 | 1.000 | Ohio Stadium · Columbus, OH |
| 12 | Sat Nov 25 | at#3Michigan | L24-30 | 11-1 | .917 | Michigan Stadium · Ann Arbor, MI |
| BOWLS | Fri Dec 29 | vs#9Missouri | L3-14 | 11-2 | .846 | Ohio Stadium · Columbus, OH |
