| 1 | Sat Aug 31 | vs Idaho | W24-14 | 1-0 | 1.000 | Autzen Stadium · Eugene, OR |
| 2 | Sat Sep 7 | vs Boise St | W37-34 | 2-0 | 1.000 | Autzen Stadium · Eugene, OR |
| 3 | Sat Sep 14 | at Oregon St | W49-14 | 3-0 | 1.000 | Reser Stadium · Corvallis, OR |
| 5 | Sat Sep 28 | at UCLA | W34-13 | 4-0 | 1.000 | Rose Bowl · Pasadena, CA |
| 6 | Fri Oct 4 | vs Michigan St | W31-10 | 5-0 | 1.000 | Autzen Stadium · Eugene, OR |
| 7 | Sat Oct 12 | vs #2Ohio State | W32-31 | 6-0 | 1.000 | Autzen Stadium · Eugene, OR |
| 8 | Fri Oct 18 | at Purdue | W35-0 | 7-0 | 1.000 | Ross-Ade Stadium · West Lafayette, IN |
| 9 | Sat Oct 26 | vs #20Illinois | W38-9 | 8-0 | 1.000 | Autzen Stadium · Eugene, OR |
| 10 | Sat Nov 2 | at Michigan | W38-17 | 9-0 | 1.000 | Michigan Stadium · Ann Arbor, MI |
| 11 | Sat Nov 9 | vs Maryland | W39-18 | 10-0 | 1.000 | Autzen Stadium · Eugene, OR |
| 12 | Sat Nov 16 | at Wisconsin | W16-13 | 11-0 | 1.000 | Camp Randall Stadium · Madison, WI |
| 14 | Sat Nov 30 | vs Washington | W49-21 | 12-0 | 1.000 | Autzen Stadium · Eugene, OR |
| 15 | Sat Dec 7 | vs #3Penn State | W45-37 | 13-0 | 1.000 | Autzen Stadium · Eugene, OR |
| CFP | Wed Jan 1 | vs#8Ohio State | L21-41 | 13-1 | .929 | Autzen Stadium · Eugene, OR |
