| 1 | Sat Sep 2 | vs #3Ohio State | L3-23 | 0-1 | .000 | Memorial Stadium · Bloomington, IN |
| 2 | Fri Sep 8 | vsIndiana St | W41-7 | 1-1 | .500 | Memorial Stadium · Bloomington, IN |
| 3 | Sat Sep 16 | vsLouisville | L14-21 | 1-2 | .333 | Memorial Stadium · Bloomington, IN |
| 4 | Sat Sep 23 | vsAkron | W29-27 (4OT) | 2-2 | .500 | Memorial Stadium · Bloomington, IN |
| 5 | Sat Sep 30 | atMaryland | L17-44 | 2-3 | .400 | SECU Stadium · College Park, MD |
| 6 | Sat Oct 14 | at#2Michigan | L7-52 | 2-4 | .333 | Michigan Stadium · Ann Arbor, MI |
| 7 | Sat Oct 21 | vsRutgers | L14-31 | 2-5 | .286 | Memorial Stadium · Bloomington, IN |
| 8 | Sat Oct 28 | at#10Penn State | L24-33 | 2-6 | .250 | Beaver Stadium · University Park, PA |
| 9 | Sat Nov 4 | vsWisconsin | W20-14 | 3-6 | .333 | Memorial Stadium · Bloomington, IN |
| 10 | Sat Nov 11 | atIllinois | L45-48 (OT) | 3-7 | .300 | Alumni Memorial Field at Foster Stadium · Lexington, VA |
| 11 | Sat Nov 18 | vsMichigan St | L21-24 | 3-8 | .273 | Memorial Stadium · Bloomington, IN |
| 12 | Sat Nov 25 | atPurdue | L31-35 | 3-9 | .250 | Ross-Ade Stadium · West Lafayette, IN |
