| 1 | Sat Aug 31 | vs Sam Houston | L14-34 | 0-1 | .000 | Rice Stadium · Houston, TX |
| 2 | Sat Sep 7 | vsTexas So | W69-7 | 1-1 | .500 | Rice Stadium · Houston, TX |
| 3 | Sat Sep 14 | atHouston | L7-33 | 1-2 | .333 | Robertson Stadium · Houston, TX |
| 4 | Sat Sep 21 | atArmy | L14-37 | 1-3 | .250 | Michie Stadium · West Point, NY |
| 5 | Sat Sep 28 | vsCharlotte | L20-21 | 1-4 | .200 | Rice Stadium · Houston, TX |
| 6 | Sat Oct 12 | vsUTSA | W29-27 | 2-4 | .333 | Rice Stadium · Houston, TX |
| 7 | Sat Oct 19 | atTulane | L10-24 | 2-5 | .286 | Yulman Stadium · New Orleans, LA |
| 8 | Sat Oct 26 | atUConn | L10-17 | 2-6 | .250 | Pratt & Whitney Stadium · East Hartford, CT |
| 9 | Sat Nov 2 | vsNavy | W24-10 | 3-6 | .333 | Rice Stadium · Houston, TX |
| 10 | Fri Nov 8 | atMemphis | L20-27 | 3-7 | .300 | Simmons Bank Liberty Stadium · Memphis, TN |
| 11 | Sat Nov 23 | atUAB | L14-40 | 3-8 | .273 | Legion Field (AL) · Birmingham, AL |
| 12 | Sat Nov 30 | vsSouth Florida | W35-28 | 4-8 | .333 | Rice Stadium · Houston, TX |
