| 1 | Thu Aug 28 | vs Stony Brook | W42-0 | 1-0 | 1.000 | SDCCU Stadium · San Diego, CA |
| 2 | Sat Sep 6 | atWashington St | L13-36 | 1-1 | .500 | Gesa Field · Pullman, WA |
| 3 | Sat Sep 20 | vsCalifornia | W34-0 | 2-1 | .667 | SDCCU Stadium · San Diego, CA |
| 4 | Sat Sep 27 | atN Illinois | W6-3 | 3-1 | .750 | Huskie Stadium · Dekalb, IL |
| 5 | Fri Oct 3 | vsColorado St | W45-24 | 4-1 | .800 | SDCCU Stadium · San Diego, CA |
| 6 | Sat Oct 11 | atNevada | W44-10 | 5-1 | .833 | Mackay Stadium · Reno, NV |
| 7 | Sat Oct 25 | atFresno St | W23-0 | 6-1 | .857 | Bulldog Stadium (CA) · Fresno, CA |
| 8 | Sat Nov 1 | vsWyoming | W24-7 | 7-1 | .875 | SDCCU Stadium · San Diego, CA |
| 9 | Sat Nov 8 | atHawai'i | L6-38 | 7-2 | .778 | Aloha Stadium · Honolulu, HI |
| 10 | Sat Nov 15 | vsBoise St | W17-7 | 8-2 | .800 | SDCCU Stadium · San Diego, CA |
| 11 | Sat Nov 22 | vsSan Jose St | W25-3 | 9-2 | .818 | SDCCU Stadium · San Diego, CA |
| 12 | Fri Nov 28 | atNew Mexico | L17-23 (2OT) | 9-3 | .750 | University Stadium · Albuquerque, NM |
