| 1 | Sat Aug 31 | vs E Texas A&M | W45-14 | 1-0 | 1.000 | SDCCU Stadium · San Diego, CA |
| 2 | Sat Sep 7 | vs Oregon St | L0-21 | 1-1 | .500 | SDCCU Stadium · San Diego, CA |
| 3 | Sat Sep 14 | at California | L10-31 | 1-2 | .333 | California Memorial Stadium · Berkeley, CA |
| 5 | Sat Sep 28 | at C Michigan | L21-22 | 1-3 | .250 | Kelly/Shorts Stadium · Mount Pleasant, MI |
| 6 | Sat Oct 5 | vs Hawai'i | W27-24 | 2-3 | .400 | SDCCU Stadium · San Diego, CA |
| 7 | Sat Oct 12 | at Wyoming | W27-24 | 3-3 | .500 | Jonah Field at War Memorial Stadium · Laramie, WY |
| 9 | Sat Oct 26 | vs Washington St | L26-29 | 3-4 | .429 | SDCCU Stadium · San Diego, CA |
| 10 | Fri Nov 1 | at #15Boise St | L24-56 | 3-5 | .375 | Albertsons Stadium · Boise, ID |
| 11 | Fri Nov 8 | vs New Mexico | L16-21 | 3-6 | .333 | SDCCU Stadium · San Diego, CA |
| 12 | Sat Nov 16 | at UNLV | L20-41 | 3-7 | .300 | Sam Boyd Stadium · Las Vegas, NV |
| 13 | Sat Nov 23 | at Utah State | L20-41 | 3-8 | .273 | Maverik Stadium · Logan, UT |
| 14 | Sat Nov 30 | vs Air Force | L20-31 | 3-9 | .250 | SDCCU Stadium · San Diego, CA |
