| 1 | Sat Aug 23 | vs Fresno St | W31-7 | 1-0 | 1.000 | David Booth Kansas Memorial Stadium · Lawrence, KS |
| 2 | Fri Aug 29 | vsWagner | W46-7 | 2-0 | 1.000 | David Booth Kansas Memorial Stadium · Lawrence, KS |
| 3 | Sat Sep 6 | atMissouri | L31-42 | 2-1 | .667 | Memorial Stadium/Faurot Field · Columbia, MO |
| 4 | Sat Sep 20 | vsWest Virginia | W41-10 | 3-1 | .750 | David Booth Kansas Memorial Stadium · Lawrence, KS |
| 5 | Sat Sep 27 | vsCincinnati | L34-37 | 3-2 | .600 | David Booth Kansas Memorial Stadium · Lawrence, KS |
| 6 | Sat Oct 4 | atUCF | W27-20 | 4-2 | .667 | FBC Mortgage Stadium · Orlando, FL |
| 7 | Sat Oct 11 | at#9Texas Tech | L17-42 | 4-3 | .571 | Jones AT&T Stadium · Lubbock, TX |
| 8 | Sat Oct 25 | vsKansas St | L17-42 | 4-4 | .500 | David Booth Kansas Memorial Stadium · Lawrence, KS |
| 9 | Sat Nov 1 | vsOklahoma St | W38-21 | 5-4 | .556 | David Booth Kansas Memorial Stadium · Lawrence, KS |
| 10 | Sat Nov 8 | atArizona | L20-24 | 5-5 | .500 | Arizona Stadium · Tucson, AZ |
