| 1 | Sat Sep 4 | vs Missouri St | W23-16 | 1-0 | 1.000 | Boone Pickens Stadium · Stillwater, OK |
| 2 | Sat Sep 11 | vsTulsa | W28-23 | 2-0 | 1.000 | Boone Pickens Stadium · Stillwater, OK |
| 3 | Sat Sep 18 | atBoise St | W21-20 | 3-0 | 1.000 | Albertsons Stadium · Boise, ID |
| 4 | Sat Sep 25 | vs#25Kansas St | W31-20 | 4-0 | 1.000 | Boone Pickens Stadium · Stillwater, OK |
| 5 | Sat Oct 2 | vs#21Baylor | W24-14 | 5-0 | 1.000 | Boone Pickens Stadium · Stillwater, OK |
| 6 | Sat Oct 16 | at#25Texas | W32-24 | 6-0 | 1.000 | DKR-Texas Memorial Stadium · Austin, TX |
| 7 | Sat Oct 23 | atIowa State | L21-24 | 6-1 | .857 | Jack Trice Stadium · Ames, IA |
| 8 | Sat Oct 30 | vsKansas | W55-3 | 7-1 | .875 | Boone Pickens Stadium · Stillwater, OK |
| 9 | Sat Nov 6 | atWest Virginia | W24-3 | 8-1 | .889 | Milan Puskar Stadium · Morgantown, WV |
| 10 | Sat Nov 13 | vsTCU | W63-17 | 9-1 | .900 | Boone Pickens Stadium · Stillwater, OK |
| 11 | Sat Nov 20 | atTexas Tech | W23-0 | 10-1 | .909 | Jones AT&T Stadium · Lubbock, TX |
| 12 | Sat Nov 27 | vs#10Oklahoma | W37-33 | 11-1 | .917 | Boone Pickens Stadium · Stillwater, OK |
| 13 | Sat Dec 4 | vs#9Baylor | L16-21 | 11-2 | .846 | Boone Pickens Stadium · Stillwater, OK |
| BOWLS | Sat Jan 1 | at#5Notre Dame | W37-35 | 12-2 | .857 | Notre Dame Stadium · Notre Dame, IN |
