| 1 | Sat Aug 31 | vs Alcorn St | W38-10 | 1-0 | 1.000 | M. M. Roberts Stadium · Hattiesburg, MS |
| 2 | Sat Sep 7 | atMississippi St | L15-38 | 1-1 | .500 | Davis Wade Stadium · Starkville, MS |
| 3 | Sat Sep 14 | atTroy | W47-42 | 2-1 | .667 | Veterans Memorial Stadium · Troy, AL |
| 4 | Sat Sep 21 | at#2Alabama | L7-49 | 2-2 | .500 | Bryant-Denny Stadium · Tuscaloosa, AL |
| 5 | Sat Sep 28 | vsUTEP | W31-13 | 3-2 | .600 | M. M. Roberts Stadium · Hattiesburg, MS |
| 6 | Sat Oct 12 | vsNorth Texas | W45-27 | 4-2 | .667 | M. M. Roberts Stadium · Hattiesburg, MS |
| 7 | Sat Oct 19 | atLouisiana Tech | L30-45 | 4-3 | .571 | Joe Aillet Stadium · Ruston, LA |
| 8 | Sat Oct 26 | atRice | W20-6 | 5-3 | .625 | Rice Stadium · Houston, TX |
| 9 | Sat Nov 9 | vsUAB | W37-2 | 6-3 | .667 | M. M. Roberts Stadium · Hattiesburg, MS |
| 10 | Sat Nov 16 | atUTSA | W36-17 | 7-3 | .700 | Alamodome · San Antonio, TX |
| 11 | Sat Nov 23 | vsWestern KY | L10-28 | 7-4 | .636 | M. M. Roberts Stadium · Hattiesburg, MS |
| 12 | Sat Nov 30 | atFAU | L17-34 | 7-5 | .583 | FAU Stadium · Boca Raton, FL |
| BOWLS | Sat Jan 4 | atTulane | L13-30 | 7-6 | .538 | Yulman Stadium · New Orleans, LA |
