| 1 | Sat Aug 31 | at Kentucky | L24-38 | 0-1 | .000 | Kroger Field · Lexington, KY |
| 2 | Sat Sep 14 | vsTBD | W45-0 | 1-1 | .500 | Glass Bowl · Toledo, OH |
| 3 | Sat Sep 21 | atColorado St | W41-35 | 2-1 | .667 | Hughes Stadium (CO) · Fort Collins, CO |
| 4 | Sat Sep 28 | vsBYU | W28-21 | 3-1 | .750 | Glass Bowl · Toledo, OH |
| 5 | Sat Oct 5 | vsW Michigan | W31-24 | 4-1 | .800 | Glass Bowl · Toledo, OH |
| 6 | Sat Oct 12 | atBowling Green | L7-20 | 4-2 | .667 | Doyt L. Perry Stadium · Bowling Green, OH |
| 7 | Sat Oct 19 | atBall State | L14-52 | 4-3 | .571 | Scheumann Stadium · Muncie, IN |
| 8 | Sat Oct 26 | vsE Michigan | W37-34 (OT) | 5-3 | .625 | Glass Bowl · Toledo, OH |
| 9 | Tue Nov 5 | vsKent State | W35-33 | 6-3 | .667 | Glass Bowl · Toledo, OH |
| 10 | Wed Nov 13 | vsN Illinois | L28-31 | 6-4 | .600 | Glass Bowl · Toledo, OH |
| 11 | Wed Nov 20 | atBuffalo | L30-49 | 6-5 | .545 | UB Stadium · Buffalo, NY |
| 12 | Fri Nov 29 | atC Michigan | L7-49 | 6-6 | .500 | Kelly/Shorts Stadium · Mount Pleasant, MI |
