| 1 | Thu Sep 1 | vs Long Island | W37-0 | 1-0 | 1.000 | Glass Bowl · Toledo, OH |
| 2 | Sat Sep 10 | vsUMass | W55-10 | 2-0 | 1.000 | Glass Bowl · Toledo, OH |
| 3 | Sat Sep 17 | at#3Ohio State | L21-77 | 2-1 | .667 | Ohio Stadium · Columbus, OH |
| 4 | Sat Sep 24 | atSDSU | L14-17 | 2-2 | .500 | SDCCU Stadium · San Diego, CA |
| 5 | Sat Oct 1 | vsC Michigan | W38-17 | 3-2 | .600 | Glass Bowl · Toledo, OH |
| 6 | Sat Oct 8 | atN Illinois | W52-32 | 4-2 | .667 | Huskie Stadium · Dekalb, IL |
| 7 | Sat Oct 15 | vsKent State | W52-31 | 5-2 | .714 | Glass Bowl · Toledo, OH |
| 8 | Sat Oct 22 | atBuffalo | L27-34 | 5-3 | .625 | UB Stadium · Buffalo, NY |
| 9 | Sat Oct 29 | atE Michigan | W27-24 | 6-3 | .667 | Rynearson Stadium · Ypsilanti, MI |
| 10 | Tue Nov 8 | vsBall State | W28-21 | 7-3 | .700 | Glass Bowl · Toledo, OH |
| 11 | Tue Nov 15 | vsBowling Green | L35-42 | 7-4 | .636 | Glass Bowl · Toledo, OH |
| 12 | Fri Nov 25 | atW Michigan | L14-20 | 7-5 | .583 | Waldo Stadium · Kalamazoo, MI |
| 13 | Sat Dec 3 | atOhio | W17-7 | 8-5 | .615 | Peden Stadium · Athens, OH |
| BOWLS | Tue Dec 20 | vsLiberty | W21-19 | 9-5 | .643 | Glass Bowl · Toledo, OH |
