| 1 | Sat Aug 30 | at #19Texas A&M | L24-42 | 0-1 | .000 | Kyle Field · College Station, TX |
| 2 | Sat Sep 6 | vsTexas St | L36-43 | 0-2 | .000 | Alamodome · San Antonio, TX |
| 3 | Sat Sep 13 | vsIncarnate Word | W48-20 | 1-2 | .333 | Alamodome · San Antonio, TX |
| 4 | Sat Sep 20 | atColorado St | W17-16 | 2-2 | .500 | Hughes Stadium (CO) · Fort Collins, CO |
| 5 | Sat Oct 4 | atTemple | L21-27 | 2-3 | .400 | Lincoln Financial Field · Philadelphia, PA |
| 6 | Sat Oct 11 | vsRice | W61-13 | 3-3 | .500 | Alamodome · San Antonio, TX |
| 7 | Sat Oct 18 | atNorth Texas | L17-55 | 3-4 | .429 | DATCU Stadium · Denton, TX |
| 8 | Thu Oct 30 | vsTulane | W48-26 | 4-4 | .500 | Alamodome · San Antonio, TX |
| 9 | Thu Nov 6 | atSouth Florida | L23-55 | 4-5 | .444 | Raymond James Stadium · Tampa, FL |
| 10 | Sat Nov 15 | atCharlotte | W28-7 | 5-5 | .500 | Jerry Richardson Stadium · Charlotte, NC |
| 11 | Sat Nov 22 | vsE Carolina | W58-24 | 6-5 | .545 | Alamodome · San Antonio, TX |
| 12 | Sat Nov 29 | vsArmy | L24-27 | 6-6 | .500 | Alamodome · San Antonio, TX |
