| 1 | Sat Sep 2 | at Houston | L14-17 | 0-1 | .000 | Robertson Stadium · Houston, TX |
| 2 | Sat Sep 9 | vsTexas St | W20-13 | 1-1 | .500 | Alamodome · San Antonio, TX |
| 3 | Fri Sep 15 | vsArmy | L29-37 | 1-2 | .333 | Alamodome · San Antonio, TX |
| 4 | Sat Sep 23 | at#23Tennessee | L14-45 | 1-3 | .250 | Neyland Stadium · Knoxville, TN |
| 5 | Sat Oct 7 | atTemple | W49-34 | 2-3 | .400 | Lincoln Financial Field · Philadelphia, PA |
| 6 | Sat Oct 14 | vsUAB | W41-20 | 3-3 | .500 | Alamodome · San Antonio, TX |
| 7 | Sat Oct 21 | atFAU | W36-10 | 4-3 | .571 | FAU Stadium · Boca Raton, FL |
| 8 | Sat Oct 28 | vsE Carolina | W41-27 | 5-3 | .625 | Alamodome · San Antonio, TX |
| 9 | Sat Nov 4 | atNorth Texas | W37-29 | 6-3 | .667 | DATCU Stadium · Denton, TX |
| 10 | Sat Nov 11 | vsRice | W34-14 | 7-3 | .700 | Alamodome · San Antonio, TX |
| 11 | Fri Nov 17 | vsSouth Florida | W49-21 | 8-3 | .727 | Alamodome · San Antonio, TX |
| 12 | Fri Nov 24 | at#23Tulane | L16-29 | 8-4 | .667 | Yulman Stadium · New Orleans, LA |
| BOWLS | Tue Dec 19 | atMarshall | W35-17 | 9-4 | .692 | Joan C. Edwards Stadium · Huntington, WV |
