| 1 | Thu Jan 14 | vs Hurricanes | L0-3 | 0-1-0 | 0 PTS | Little Caesars Arena · Detroit, MI |
| 2 | Sat Jan 16 | vsHurricanes | W4-2 | 1-1-0 | 2 PTS | Little Caesars Arena · Detroit, MI |
| 3 | Mon Jan 18 | vsJackets | L2-3 | 1-2-0 | 2 PTS | Little Caesars Arena · Detroit, MI |
| 4 | Tue Jan 19 | vsJackets | W3-2 (OT) | 2-2-0 | 4 PTS | Little Caesars Arena · Detroit, MI |
| 5 | Fri Jan 22 | atBlackhawks | L1-4 | 2-3-0 | 4 PTS | United Center · Chicago, IL |
| 6 | Sun Jan 24 | atBlackhawks | L2-6 | 2-4-0 | 4 PTS | United Center · Chicago, IL |
| 7 | Tue Jan 26 | atStars | L1-2 (OT) | 2-4-1 | 5 PTS | American Airlines Center · Dallas, TX |
| 8 | Thu Jan 28 | atStars | L3-7 | 2-5-1 | 5 PTS | American Airlines Center · Dallas, TX |
| 9 | Sat Jan 30 | vsPanthers | L2-3 (OT) | 2-5-2 | 6 PTS | Little Caesars Arena · Detroit, MI |
| 10 | Sun Jan 31 | vsPanthers | L2-3 | 2-6-2 | 6 PTS | Little Caesars Arena · Detroit, MI |
| 11 | Wed Feb 3 | atLightning | L1-5 | 2-7-2 | 6 PTS | AMALIE Arena · Tampa, FL |
| 12 | Fri Feb 5 | atLightning | L1-3 | 2-8-2 | 6 PTS | AMALIE Arena · Tampa, FL |
| 13 | Sun Feb 7 | atPanthers | W4-1 | 3-8-2 | 8 PTS | Amerant Bank Arena · Sunrise, FL |
| 14 | Tue Feb 9 | atPanthers | L1-2 | 3-9-2 | 8 PTS | Amerant Bank Arena · Sunrise, FL |
| 15 | Thu Feb 11 | atPredators | L2-3 | 3-10-2 | 8 PTS | Bridgestone Arena · Nashville, TN |
| 16 | Sat Feb 13 | atPredators | W4-2 | 4-10-2 | 10 PTS | Bridgestone Arena · Nashville, TN |
| 17 | Mon Feb 15 | vsBlackhawks | L2-3 (OT) | 4-10-3 | 11 PTS | Little Caesars Arena · Detroit, MI |
| 18 | Wed Feb 17 | vsBlackhawks | L0-2 | 4-11-3 | 11 PTS | Little Caesars Arena · Detroit, MI |
| 19 | Fri Feb 19 | vsPanthers | L2-7 | 4-12-3 | 11 PTS | Little Caesars Arena · Detroit, MI |
| 20 | Sat Feb 20 | vsPanthers | W2-1 | 5-12-3 | 13 PTS | Little Caesars Arena · Detroit, MI |
| 21 | Tue Feb 23 | vsPredators | L0-2 | 5-13-3 | 13 PTS | Little Caesars Arena · Detroit, MI |
| 22 | Thu Feb 25 | vsPredators | W5-2 | 6-13-3 | 15 PTS | Little Caesars Arena · Detroit, MI |
| 23 | Sat Feb 27 | atBlackhawks | W5-3 | 7-13-3 | 17 PTS | United Center · Chicago, IL |
| 24 | Sun Feb 28 | atBlackhawks | L2-7 | 7-14-3 | 17 PTS | United Center · Chicago, IL |
| 25 | Tue Mar 2 | atJackets | L1-4 | 7-15-3 | 17 PTS | Nationwide Arena · Columbus, OH |
| 26 | Thu Mar 4 | atHurricanes | L2-5 | 7-16-3 | 17 PTS | PNC Arena · Raleigh, NC |
| 27 | Tue Mar 9 | vsLightning | L3-4 (OT) | 7-16-4 | 18 PTS | Little Caesars Arena · Detroit, MI |
| 28 | Thu Mar 11 | vsLightning | W6-4 | 8-16-4 | 20 PTS | Little Caesars Arena · Detroit, MI |
| 29 | Sun Mar 14 | vsHurricanes | L1-2 | 8-17-4 | 20 PTS | Little Caesars Arena · Detroit, MI |
| 30 | Tue Mar 16 | vsHurricanes | W4-2 | 9-17-4 | 22 PTS | Little Caesars Arena · Detroit, MI |
| 31 | Thu Mar 18 | vsStars | W3-2 | 10-17-4 | 24 PTS | Little Caesars Arena · Detroit, MI |
| 32 | Sat Mar 20 | vsStars | L0-3 | 10-18-4 | 24 PTS | Little Caesars Arena · Detroit, MI |
| 33 | Tue Mar 23 | atPredators | L0-2 | 10-19-4 | 24 PTS | Bridgestone Arena · Nashville, TN |
| 34 | Thu Mar 25 | atPredators | L1-7 | 10-20-4 | 24 PTS | Bridgestone Arena · Nashville, TN |
| 35 | Sat Mar 27 | vsJackets | W3-1 | 11-20-4 | 26 PTS | Little Caesars Arena · Detroit, MI |
| 36 | Sun Mar 28 | vsJackets | W4-1 | 12-20-4 | 28 PTS | Little Caesars Arena · Detroit, MI |
| 37 | Tue Mar 30 | atPanthers | L1-4 | 12-21-4 | 28 PTS | Amerant Bank Arena · Sunrise, FL |
| 38 | Thu Apr 1 | atPanthers | L2-3 (OT) | 12-21-5 | 29 PTS | Amerant Bank Arena · Sunrise, FL |
| 39 | Sat Apr 3 | atLightning | L1-2 | 12-22-5 | 29 PTS | AMALIE Arena · Tampa, FL |
| 40 | Sun Apr 4 | atLightning | W5-1 | 13-22-5 | 31 PTS | AMALIE Arena · Tampa, FL |
| 41 | Tue Apr 6 | vsPredators | L2-3 (SO) | 13-22-6 | 32 PTS | Little Caesars Arena · Detroit, MI |
| 42 | Thu Apr 8 | vsPredators | L1-7 | 13-23-6 | 32 PTS | Little Caesars Arena · Detroit, MI |
| 43 | Sat Apr 10 | atHurricanes | W5-4 (SO) | 14-23-6 | 34 PTS | PNC Arena · Raleigh, NC |
| 44 | Mon Apr 12 | atHurricanes | W3-1 | 15-23-6 | 36 PTS | PNC Arena · Raleigh, NC |
| 45 | Thu Apr 15 | vsBlackhawks | W4-1 | 16-23-6 | 38 PTS | Little Caesars Arena · Detroit, MI |
| 46 | Sat Apr 17 | vsBlackhawks | L0-4 | 16-24-6 | 38 PTS | Little Caesars Arena · Detroit, MI |
| 47 | Mon Apr 19 | atStars | L2-3 (SO) | 16-24-7 | 39 PTS | American Airlines Center · Dallas, TX |
| 48 | Tue Apr 20 | atStars | L2-5 | 16-25-7 | 39 PTS | American Airlines Center · Dallas, TX |
| 49 | Thu Apr 22 | vsStars | W7-3 | 17-25-7 | 41 PTS | Little Caesars Arena · Detroit, MI |
| 50 | Sat Apr 24 | vsStars | L1-2 (OT) | 17-25-8 | 42 PTS | Little Caesars Arena · Detroit, MI |
| 51 | Tue Apr 27 | atJackets | L0-1 (SO) | 17-25-9 | 43 PTS | Nationwide Arena · Columbus, OH |
| 52 | Thu Apr 29 | atHurricanes | L1-3 | 17-26-9 | 43 PTS | PNC Arena · Raleigh, NC |
| 53 | Sat May 1 | vsLightning | W1-0 (SO) | 18-26-9 | 45 PTS | Little Caesars Arena · Detroit, MI |
| 54 | Sun May 2 | vsLightning | L1-2 | 18-27-9 | 45 PTS | Little Caesars Arena · Detroit, MI |
| 55 | Fri May 7 | atJackets | W5-2 | 19-27-9 | 47 PTS | Nationwide Arena · Columbus, OH |
| 56 | Sat May 8 | atJackets | L4-5 (OT) | 19-27-10 | 48 PTS | Nationwide Arena · Columbus, OH |
