| 1 | Thu Oct 12 | at Devils | L3-4 | 0-1-0 | 0 PTS | Prudential Center · Newark, NJ |
| 2 | Sat Oct 14 | vsLightning | W6-4 | 1-1-0 | 2 PTS | Little Caesars Arena · Detroit, MI |
| 3 | Mon Oct 16 | atJackets | W4-0 | 2-1-0 | 4 PTS | Nationwide Arena · Columbus, OH |
| 4 | Wed Oct 18 | vsPenguins | W6-3 | 3-1-0 | 6 PTS | Little Caesars Arena · Detroit, MI |
| 5 | Sat Oct 21 | atSenators | W5-2 | 4-1-0 | 8 PTS | Canadian Tire Centre · Ottawa, ON |
| 6 | Sun Oct 22 | vsFlames | W6-2 | 5-1-0 | 10 PTS | Little Caesars Arena · Detroit, MI |
| 7 | Tue Oct 24 | vsKraken | L4-5 (OT) | 5-1-1 | 11 PTS | Little Caesars Arena · Detroit, MI |
| 8 | Thu Oct 26 | vsJets | L1-4 | 5-2-1 | 11 PTS | Little Caesars Arena · Detroit, MI |
| 9 | Sat Oct 28 | atBruins | L1-4 | 5-3-1 | 11 PTS | TD Garden · Boston, MA |
| 10 | Mon Oct 30 | atIslanders | W4-3 (OT) | 6-3-1 | 13 PTS | UBS Arena · Elmont, NY |
| 11 | Thu Nov 2 | vsPanthers | L0-2 | 6-4-1 | 13 PTS | Little Caesars Arena · Detroit, MI |
| 12 | Sat Nov 4 | vsBruins | W5-4 | 7-4-1 | 15 PTS | Little Caesars Arena · Detroit, MI |
| 13 | Tue Nov 7 | atRangers | L3-5 | 7-5-1 | 15 PTS | Madison Square Garden · Manhattan, NY |
| 14 | Thu Nov 9 | vsCanadiens | L2-3 (OT) | 7-5-2 | 16 PTS | Little Caesars Arena · Detroit, MI |
| 15 | Sat Nov 11 | vsJackets | W5-4 | 8-5-2 | 18 PTS | Little Caesars Arena · Detroit, MI |
| 16 | Thu Nov 16 | atSenators | L4-5 (OT) | 8-5-3 | 19 PTS | Canadian Tire Centre · Ottawa, ON |
| 17 | Fri Nov 17 | vsMaple Leafs | L2-3 | 8-6-3 | 19 PTS | Little Caesars Arena · Detroit, MI |
| 18 | Wed Nov 22 | vsDevils | W4-0 | 9-6-3 | 21 PTS | Little Caesars Arena · Detroit, MI |
| 19 | Fri Nov 24 | atBruins | W5-2 | 10-6-3 | 23 PTS | TD Garden · Boston, MA |
| 20 | Sun Nov 26 | vsWild | W4-1 | 11-6-3 | 25 PTS | Little Caesars Arena · Detroit, MI |
| 21 | Wed Nov 29 | atRangers | L2-3 | 11-7-3 | 25 PTS | Madison Square Garden · Manhattan, NY |
| 22 | Thu Nov 30 | vsBlackhawks | W5-1 | 12-7-3 | 27 PTS | Little Caesars Arena · Detroit, MI |
| 23 | Sat Dec 2 | atCanadiens | W5-4 (OT) | 13-7-3 | 29 PTS | Bell Centre · Montreal, QC |
| 24 | Tue Dec 5 | atSabres | W5-3 | 14-7-3 | 31 PTS | KeyBank Center · Buffalo, NY |
| 25 | Thu Dec 7 | vsSharks | L5-6 (OT) | 14-7-4 | 32 PTS | Little Caesars Arena · Detroit, MI |
| 26 | Sat Dec 9 | vsSenators | L1-5 | 14-8-4 | 32 PTS | Little Caesars Arena · Detroit, MI |
| 27 | Mon Dec 11 | atStars | L3-6 | 14-9-4 | 32 PTS | American Airlines Center · Dallas, TX |
| 28 | Tue Dec 12 | atBlues | W6-4 | 15-9-4 | 34 PTS | Enterprise Center · St. Louis, MO |
| 29 | Thu Dec 14 | vsHurricanes | L1-2 | 15-10-4 | 34 PTS | Little Caesars Arena · Detroit, MI |
| 30 | Sat Dec 16 | atFlyers | L0-1 | 15-11-4 | 34 PTS | Wells Fargo Center · Philadelphia, PA |
| 31 | Mon Dec 18 | vsDucks | L3-4 | 15-12-4 | 34 PTS | Little Caesars Arena · Detroit, MI |
| 32 | Wed Dec 20 | atJets | L2-5 | 15-13-4 | 34 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 33 | Fri Dec 22 | vsFlyers | W7-6 (SO) | 16-13-4 | 36 PTS | Little Caesars Arena · Detroit, MI |
| 34 | Sat Dec 23 | atDevils | L2-3 | 16-14-4 | 36 PTS | Prudential Center · Newark, NJ |
| 35 | Wed Dec 27 | atWild | L3-6 | 16-15-4 | 36 PTS | Xcel Energy Center · St. Paul, MN |
| 36 | Fri Dec 29 | vsPredators | W5-4 (OT) | 17-15-4 | 38 PTS | Little Caesars Arena · Detroit, MI |
| 37 | Sun Dec 31 | vsBruins | L3-5 | 17-16-4 | 38 PTS | Little Caesars Arena · Detroit, MI |
| 38 | Tue Jan 2 | atSharks | W5-3 | 18-16-4 | 40 PTS | SAP Center · San Jose, CA |
| 39 | Thu Jan 4 | atKings | W4-3 (SO) | 19-16-4 | 42 PTS | Crypto.com Arena · Los Angeles, CA |
| 40 | Sun Jan 7 | atDucks | W3-2 | 20-16-4 | 44 PTS | Honda Center · Anaheim, CA |
| 41 | Thu Jan 11 | vsOilers | L2-3 (OT) | 20-16-5 | 45 PTS | Little Caesars Arena · Detroit, MI |
| 42 | Sat Jan 13 | vsKings | W5-3 | 21-16-5 | 47 PTS | Little Caesars Arena · Detroit, MI |
| 43 | Sun Jan 14 | atMaple Leafs | W4-2 | 22-16-5 | 49 PTS | Scotiabank Arena · Toronto, ON |
| 44 | Wed Jan 17 | atPanthers | W3-2 (OT) | 23-16-5 | 51 PTS | Amerant Bank Arena · Sunrise, FL |
| 45 | Fri Jan 19 | atHurricanes | L2-4 | 23-17-5 | 51 PTS | PNC Arena · Raleigh, NC |
| 46 | Sun Jan 21 | vsLightning | W2-1 | 24-17-5 | 53 PTS | Little Caesars Arena · Detroit, MI |
| 47 | Tue Jan 23 | vsStars | L4-5 | 24-18-5 | 53 PTS | Little Caesars Arena · Detroit, MI |
| 48 | Thu Jan 25 | vsFlyers | W3-0 | 25-18-5 | 55 PTS | Little Caesars Arena · Detroit, MI |
| 49 | Sat Jan 27 | vsKnights | W5-2 | 26-18-5 | 57 PTS | Little Caesars Arena · Detroit, MI |
| 50 | Wed Jan 31 | vsSenators | L2-3 (OT) | 26-18-6 | 58 PTS | Little Caesars Arena · Detroit, MI |
| 51 | Sat Feb 10 | vsCanucks | W4-3 (OT) | 27-18-6 | 60 PTS | Little Caesars Arena · Detroit, MI |
| 52 | Tue Feb 13 | atOilers | L4-8 | 27-19-6 | 60 PTS | Rogers Place · Edmonton, AB |
| 53 | Thu Feb 15 | atCanucks | L1-4 | 27-20-6 | 60 PTS | Rogers Arena · Vancouver, British Columbia |
| 54 | Sat Feb 17 | atFlames | W5-0 | 28-20-6 | 62 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 55 | Mon Feb 19 | atKraken | W4-3 (OT) | 29-20-6 | 64 PTS | Climate Pledge Arena · Seattle, WA |
| 56 | Thu Feb 22 | vsAvalanche | W2-1 (OT) | 30-20-6 | 66 PTS | Little Caesars Arena · Detroit, MI |
| 57 | Sat Feb 24 | vsBlues | W6-1 | 31-20-6 | 68 PTS | Little Caesars Arena · Detroit, MI |
| 58 | Sun Feb 25 | atBlackhawks | W3-2 (OT) | 32-20-6 | 70 PTS | United Center · Chicago, IL |
| 59 | Tue Feb 27 | vsCapitals | W8-3 | 33-20-6 | 72 PTS | Little Caesars Arena · Detroit, MI |
| 60 | Thu Feb 29 | vsIslanders | L3-5 | 33-21-6 | 72 PTS | Little Caesars Arena · Detroit, MI |
| 61 | Sat Mar 2 | vsPanthers | L0-4 | 33-22-6 | 72 PTS | Little Caesars Arena · Detroit, MI |
| 62 | Wed Mar 6 | atAvalanche | L2-7 | 33-23-6 | 72 PTS | Ball Arena · Denver, CO |
| 63 | Fri Mar 8 | atCoyotes | L0-4 | 33-24-6 | 72 PTS | Mullett Arena · Tempe, AZ |
| 64 | Sat Mar 9 | atKnights | L3-5 | 33-25-6 | 72 PTS | T-Mobile Arena · Las Vegas, NV |
| 65 | Tue Mar 12 | atSabres | L3-7 | 33-26-6 | 72 PTS | KeyBank Center · Buffalo, NY |
| 66 | Thu Mar 14 | vsCoyotes | L1-4 | 33-27-6 | 72 PTS | Little Caesars Arena · Detroit, MI |
| 67 | Sat Mar 16 | vsSabres | W4-1 | 34-27-6 | 74 PTS | Little Caesars Arena · Detroit, MI |
| 68 | Sun Mar 17 | atPenguins | L3-6 | 34-28-6 | 74 PTS | PPG Paints Arena · Pittsburgh, PA |
| 69 | Tue Mar 19 | vsJackets | W4-3 (OT) | 35-28-6 | 76 PTS | Little Caesars Arena · Detroit, MI |
| 70 | Thu Mar 21 | vsIslanders | W6-3 | 36-28-6 | 78 PTS | Little Caesars Arena · Detroit, MI |
| 71 | Sat Mar 23 | atPredators | L0-1 | 36-29-6 | 78 PTS | Bridgestone Arena · Nashville, TN |
| 72 | Tue Mar 26 | atCapitals | L3-4 (OT) | 36-29-7 | 79 PTS | Capital One Arena · Washington, D.C. |
| 73 | Thu Mar 28 | atHurricanes | L0-4 | 36-30-7 | 79 PTS | PNC Arena · Raleigh, NC |
| 74 | Sat Mar 30 | atPanthers | L2-3 (SO) | 36-30-8 | 80 PTS | Amerant Bank Arena · Sunrise, FL |
| 75 | Mon Apr 1 | atLightning | W4-2 | 37-30-8 | 82 PTS | AMALIE Arena · Tampa, FL |
| 76 | Fri Apr 5 | vsRangers | L3-4 | 37-31-8 | 82 PTS | Little Caesars Arena · Detroit, MI |
| 77 | Sun Apr 7 | vsSabres | W3-1 | 38-31-8 | 84 PTS | Little Caesars Arena · Detroit, MI |
| 78 | Tue Apr 9 | vsCapitals | L1-2 | 38-32-8 | 84 PTS | Little Caesars Arena · Detroit, MI |
| 79 | Thu Apr 11 | atPenguins | L5-6 (OT) | 38-32-9 | 85 PTS | PPG Paints Arena · Pittsburgh, PA |
| 80 | Sat Apr 13 | atMaple Leafs | W5-4 (OT) | 39-32-9 | 87 PTS | Scotiabank Arena · Toronto, ON |
| 81 | Mon Apr 15 | vsCanadiens | W5-4 (OT) | 40-32-9 | 89 PTS | Little Caesars Arena · Detroit, MI |
| 82 | Tue Apr 16 | atCanadiens | W5-4 (SO) | 41-32-9 | 91 PTS | Bell Centre · Montreal, QC |
