| 1 | Wed Sep 30 | at Flyers | 7:30 PM | 43-27-12 | 98 PTS | Xfinity Mobile Arena · Philadelphia, PA |
| 2 | Sat Oct 3 | vsCanadiens | 7:00 PM | 48-24-10 | 106 PTS | PPG Paints Arena · Pittsburgh, PA |
| 3 | Mon Oct 5 | vsJets | 7:30 PM | 35-35-12 | 82 PTS | PPG Paints Arena · Pittsburgh, PA |
| 4 | Wed Oct 7 | atCapitals | 7:30 PM | 43-30-9 | 95 PTS | Capital One Arena · Washington, D.C. |
| 5 | Fri Oct 9 | atJackets | 7:00 PM | 40-30-12 | 92 PTS | Nationwide Arena · Columbus, OH |
| 6 | Sat Oct 10 | vsStars | 7:00 PM | 50-20-12 | 112 PTS | PPG Paints Arena · Pittsburgh, PA |
| 7 | Tue Oct 13 | atBlackhawks | 8:00 PM | 29-39-14 | 72 PTS | United Center · Chicago, IL |
| 8 | Fri Oct 16 | atAvalanche | 9:00 PM | 55-16-11 | 121 PTS | Ball Arena · Denver, CO |
| 9 | Sat Oct 17 | atKnights | 10:00 PM | 39-26-17 | 95 PTS | T-Mobile Arena · Las Vegas, NV |
| 10 | Mon Oct 19 | atMammoth | 9:00 PM | 43-33-6 | 92 PTS | Delta Center · Salt Lake City, UT |
| 11 | Thu Oct 22 | vsPanthers | 7:00 PM | 40-38-4 | 84 PTS | PPG Paints Arena · Pittsburgh, PA |
| 12 | Sat Oct 24 | vsPredators | 7:00 PM | 38-34-10 | 86 PTS | PPG Paints Arena · Pittsburgh, PA |
| 13 | Thu Oct 29 | vsMammoth | 7:00 PM | 43-33-6 | 92 PTS | PPG Paints Arena · Pittsburgh, PA |
| 14 | Sat Oct 31 | atCanadiens | 7:00 PM | 48-24-10 | 106 PTS | Bell Centre · Montreal, QC |
| 15 | Tue Nov 3 | vsKnights | 7:00 PM | 39-26-17 | 95 PTS | PPG Paints Arena · Pittsburgh, PA |
| 16 | Thu Nov 5 | vsBruins | 7:00 PM | 45-27-10 | 100 PTS | PPG Paints Arena · Pittsburgh, PA |
| 17 | Sat Nov 7 | atKings | 9:00 PM | 35-27-20 | 90 PTS | Crypto.com Arena · Los Angeles, CA |
| 18 | Sun Nov 8 | atDucks | 8:00 PM | 43-33-6 | 92 PTS | Honda Center · Anaheim, CA |
| 19 | Wed Nov 11 | atSharks | 10:00 PM | 39-35-8 | 86 PTS | SAP Center · San Jose, CA |
| 20 | Sat Nov 14 | vsSenators | 7:00 PM | 44-27-11 | 99 PTS | PPG Paints Arena · Pittsburgh, PA |
| 21 | Thu Nov 19 | vsBlues | 7:00 PM | 37-33-12 | 86 PTS | PPG Paints Arena · Pittsburgh, PA |
| 22 | Sat Nov 21 | atPredators | 6:00 PM | 38-34-10 | 86 PTS | Bridgestone Arena · Nashville, TN |
| 23 | Sun Nov 22 | atStars | 7:00 PM | 50-20-12 | 112 PTS | American Airlines Center · Dallas, TX |
| 24 | Wed Nov 25 | vsFlames | 7:00 PM | 34-39-9 | 77 PTS | PPG Paints Arena · Pittsburgh, PA |
| 25 | Fri Nov 27 | atSabres | 8:00 PM | 50-23-9 | 109 PTS | KeyBank Center · Buffalo, NY |
| 26 | Sat Nov 28 | vsMaple Leafs | 7:00 PM | 32-36-14 | 78 PTS | PPG Paints Arena · Pittsburgh, PA |
| 27 | Mon Nov 30 | vsJackets | 7:00 PM | 40-30-12 | 92 PTS | PPG Paints Arena · Pittsburgh, PA |
| 28 | Wed Dec 2 | atBlues | 8:00 PM | 37-33-12 | 86 PTS | Enterprise Center · St. Louis, MO |
| 29 | Sat Dec 5 | vsDevils | 3:00 PM | 42-37-3 | 87 PTS | PPG Paints Arena · Pittsburgh, PA |
| 30 | Sun Dec 6 | vsSharks | 3:00 PM | 39-35-8 | 86 PTS | PPG Paints Arena · Pittsburgh, PA |
| 31 | Tue Dec 8 | vsBlackhawks | 7:00 PM | 29-39-14 | 72 PTS | PPG Paints Arena · Pittsburgh, PA |
| 32 | Thu Dec 10 | atPanthers | 7:00 PM | 40-38-4 | 84 PTS | Amerant Bank Arena · Sunrise, FL |
| 33 | Sat Dec 12 | atLightning | 3:30 PM | 50-26-6 | 106 PTS | Benchmark International Arena · Tampa, FL |
| 34 | Tue Dec 15 | vsLightning | 7:00 PM | 50-26-6 | 106 PTS | PPG Paints Arena · Pittsburgh, PA |
| 35 | Thu Dec 17 | vsKings | 7:00 PM | 35-27-20 | 90 PTS | PPG Paints Arena · Pittsburgh, PA |
| 36 | Fri Dec 18 | vsKraken | 7:00 PM | 34-37-11 | 79 PTS | PPG Paints Arena · Pittsburgh, PA |
| 37 | Tue Dec 22 | vsSabres | 7:00 PM | 50-23-9 | 109 PTS | PPG Paints Arena · Pittsburgh, PA |
| 38 | Sat Dec 26 | atHurricanes | 7:00 PM | 53-22-7 | 113 PTS | PNC Arena · Raleigh, NC |
| 39 | Tue Dec 29 | vsHurricanes | 7:00 PM | 53-22-7 | 113 PTS | PPG Paints Arena · Pittsburgh, PA |
| 40 | Thu Dec 31 | atSenators | 2:00 PM | 44-27-11 | 99 PTS | Canadian Tire Centre · Ottawa, ON |
| 41 | Fri Jan 1 | vsWild | 6:00 PM | 46-24-12 | 104 PTS | PPG Paints Arena · Pittsburgh, PA |
| 42 | Sun Jan 3 | vsOilers | 3:00 PM | 41-30-11 | 93 PTS | PPG Paints Arena · Pittsburgh, PA |
| 43 | Thu Jan 7 | atHurricanes | 7:00 PM | 53-22-7 | 113 PTS | PNC Arena · Raleigh, NC |
| 44 | Sat Jan 9 | atCanadiens | 7:00 PM | 48-24-10 | 106 PTS | Bell Centre · Montreal, QC |
| 45 | Tue Jan 12 | vsAvalanche | 7:00 PM | 55-16-11 | 121 PTS | PPG Paints Arena · Pittsburgh, PA |
| 46 | Wed Jan 13 | atIslanders | 7:30 PM | 43-34-5 | 91 PTS | UBS Arena · Elmont, NY |
| 47 | Sat Jan 16 | atMaple Leafs | 7:00 PM | 32-36-14 | 78 PTS | Scotiabank Arena · Toronto, ON |
| 48 | Mon Jan 18 | vsCapitals | 4:00 PM | 43-30-9 | 95 PTS | PPG Paints Arena · Pittsburgh, PA |
| 49 | Thu Jan 21 | vsDucks | 7:00 PM | 43-33-6 | 92 PTS | PPG Paints Arena · Pittsburgh, PA |
| 50 | Sat Jan 23 | vsCanucks | 7:00 PM | 25-49-8 | 58 PTS | PPG Paints Arena · Pittsburgh, PA |
| 51 | Mon Jan 25 | atRed Wings | 7:00 PM | 41-31-10 | 92 PTS | Little Caesars Arena · Detroit, MI |
| 52 | Tue Jan 26 | vsIslanders | 7:00 PM | 43-34-5 | 91 PTS | PPG Paints Arena · Pittsburgh, PA |
| 53 | Fri Jan 29 | vsRangers | 7:00 PM | 34-39-9 | 77 PTS | PPG Paints Arena · Pittsburgh, PA |
| 54 | Sun Jan 31 | vsFlyers | 12:00 PM | 43-27-12 | 98 PTS | PPG Paints Arena · Pittsburgh, PA |
| 55 | Tue Feb 2 | vsLightning | 7:00 PM | 50-26-6 | 106 PTS | PPG Paints Arena · Pittsburgh, PA |
| 56 | Sat Feb 13 | atOilers | 7:00 PM | 41-30-11 | 93 PTS | Rogers Place · Edmonton, AB |
| 57 | Mon Feb 15 | atKraken | 4:00 PM | 34-37-11 | 79 PTS | Climate Pledge Arena · Seattle, WA |
| 58 | Tue Feb 16 | atCanucks | 9:00 PM | 25-49-8 | 58 PTS | Rogers Arena · Vancouver, British Columbia |
| 59 | Fri Feb 19 | atFlames | 8:00 PM | 34-39-9 | 77 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 60 | Sun Feb 21 | atJets | 6:00 PM | 35-35-12 | 82 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 61 | Tue Feb 23 | atWild | 8:00 PM | 46-24-12 | 104 PTS | Xcel Energy Center · St. Paul, MN |
| 62 | Thu Feb 25 | vsMaple Leafs | 7:00 PM | 32-36-14 | 78 PTS | PPG Paints Arena · Pittsburgh, PA |
| 63 | Sun Feb 28 | vsRangers | 1:00 PM | 34-39-9 | 77 PTS | PPG Paints Arena · Pittsburgh, PA |
| 64 | Tue Mar 2 | atSabres | 7:00 PM | 50-23-9 | 109 PTS | KeyBank Center · Buffalo, NY |
| 65 | Thu Mar 4 | atPanthers | 7:00 PM | 40-38-4 | 84 PTS | Amerant Bank Arena · Sunrise, FL |
| 66 | Sat Mar 6 | atBruins | 12:00 PM | 45-27-10 | 100 PTS | TD Garden · Boston, MA |
| 67 | Sun Mar 7 | atIslanders | 1:00 PM | 43-34-5 | 91 PTS | UBS Arena · Elmont, NY |
| 68 | Tue Mar 9 | vsSenators | 7:00 PM | 44-27-11 | 99 PTS | PPG Paints Arena · Pittsburgh, PA |
| 69 | Thu Mar 11 | vsBruins | 7:00 PM | 45-27-10 | 100 PTS | PPG Paints Arena · Pittsburgh, PA |
| 70 | Sat Mar 13 | vsCapitals | 3:00 PM | 43-30-9 | 95 PTS | PPG Paints Arena · Pittsburgh, PA |
| 71 | Sun Mar 14 | vsRed Wings | 2:00 PM | 41-31-10 | 92 PTS | PPG Paints Arena · Pittsburgh, PA |
| 72 | Tue Mar 16 | atJackets | 7:00 PM | 40-30-12 | 92 PTS | Nationwide Arena · Columbus, OH |
| 73 | Thu Mar 18 | atDevils | 7:00 PM | 42-37-3 | 87 PTS | Prudential Center · Newark, NJ |
| 74 | Sat Mar 20 | atRangers | 8:00 PM | 34-39-9 | 77 PTS | Madison Square Garden · Manhattan, NY |
| 75 | Mon Mar 22 | vsJackets | 7:00 PM | 40-30-12 | 92 PTS | PPG Paints Arena · Pittsburgh, PA |
| 76 | Thu Mar 25 | vsDevils | 7:00 PM | 42-37-3 | 87 PTS | PPG Paints Arena · Pittsburgh, PA |
| 77 | Sat Mar 27 | vsHurricanes | 7:00 PM | 53-22-7 | 113 PTS | PPG Paints Arena · Pittsburgh, PA |
| 78 | Tue Mar 30 | atFlyers | 7:00 PM | 43-27-12 | 98 PTS | Xfinity Mobile Arena · Philadelphia, PA |
| 79 | Thu Apr 1 | vsIslanders | 7:00 PM | 43-34-5 | 91 PTS | PPG Paints Arena · Pittsburgh, PA |
| 80 | Sat Apr 3 | vsFlyers | 8:00 PM | 43-27-12 | 98 PTS | PPG Paints Arena · Pittsburgh, PA |
| 81 | Sun Apr 4 | atCapitals | 7:00 PM | 43-30-9 | 95 PTS | Capital One Arena · Washington, D.C. |
| 82 | Tue Apr 6 | atRangers | 7:30 PM | 34-39-9 | 77 PTS | Madison Square Garden · Manhattan, NY |
| 83 | Fri Apr 9 | atRed Wings | 7:00 PM | 41-31-10 | 92 PTS | Little Caesars Arena · Detroit, MI |
| 84 | Sat Apr 10 | atDevils | 6:00 PM | 42-37-3 | 87 PTS | Prudential Center · Newark, NJ |
