| 9 | Sat Oct 25 | vs Jackets | 7:00 PM | 3-3-0 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 10 | Mon Oct 27 | vsBlues | 7:00 PM | 3-2-1 | 7 PTS | PPG Paints Arena · Pittsburgh, PA |
| 11 | Tue Oct 28 | atFlyers | 6:00 PM | 3-2-1 | 7 PTS | Wells Fargo Center · Philadelphia, PA |
| 12 | Thu Oct 30 | atWild | 8:00 PM | 3-4-1 | 7 PTS | Xcel Energy Center · St. Paul, MN |
| 13 | Sat Nov 1 | atJets | 3:00 PM | 5-1-0 | 10 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 14 | Mon Nov 3 | atMaple Leafs | 7:30 PM | 3-3-1 | 7 PTS | Scotiabank Arena · Toronto, ON |
| 15 | Thu Nov 6 | vsCapitals | 7:30 PM | 5-2-0 | 10 PTS | PPG Paints Arena · Pittsburgh, PA |
| 16 | Sat Nov 8 | atDevils | 12:30 PM | 6-1-0 | 12 PTS | Prudential Center · Newark, NJ |
| 17 | Sun Nov 9 | vsKings | 2:00 PM | 2-3-2 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 18 | Fri Nov 14 | atPredators | 2:00 PM | 2-3-2 | 6 PTS | Bridgestone Arena · Nashville, TN |
| 19 | Sun Nov 16 | vsPredators | 9:00 AM | 2-3-2 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 20 | Fri Nov 21 | vsWild | 7:00 PM | 3-4-1 | 7 PTS | PPG Paints Arena · Pittsburgh, PA |
| 21 | Sat Nov 22 | vsKraken | 7:00 PM | 3-2-2 | 8 PTS | PPG Paints Arena · Pittsburgh, PA |
| 22 | Wed Nov 26 | vsSabres | 7:00 PM | 3-4-0 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 23 | Fri Nov 28 | atJackets | 7:00 PM | 3-3-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 24 | Sat Nov 29 | vsMaple Leafs | 7:00 PM | 3-3-1 | 7 PTS | PPG Paints Arena · Pittsburgh, PA |
| 25 | Mon Dec 1 | atFlyers | 7:00 PM | 3-2-1 | 7 PTS | Wells Fargo Center · Philadelphia, PA |
| 26 | Thu Dec 4 | atLightning | 7:00 PM | 1-3-2 | 4 PTS | AMALIE Arena · Tampa, FL |
| 27 | Sun Dec 7 | atStars | 6:00 PM | 3-3-0 | 6 PTS | American Airlines Center · Dallas, TX |
| 28 | Tue Dec 9 | vsDucks | 7:00 PM | 3-2-1 | 7 PTS | PPG Paints Arena · Pittsburgh, PA |
| 29 | Thu Dec 11 | vsCanadiens | 7:00 PM | 6-2-0 | 12 PTS | PPG Paints Arena · Pittsburgh, PA |
| 30 | Sat Dec 13 | vsSharks | 3:00 PM | 0-4-2 | 2 PTS | PPG Paints Arena · Pittsburgh, PA |
| 31 | Sun Dec 14 | vsMammoth | 3:00 PM | 5-2-0 | 10 PTS | PPG Paints Arena · Pittsburgh, PA |
| 32 | Tue Dec 16 | vsOilers | 7:30 PM | 3-3-1 | 7 PTS | PPG Paints Arena · Pittsburgh, PA |
| 33 | Thu Dec 18 | atSenators | 7:00 PM | 2-4-1 | 5 PTS | Canadian Tire Centre · Ottawa, ON |
| 34 | Sat Dec 20 | atCanadiens | 7:00 PM | 6-2-0 | 12 PTS | Bell Centre · Montreal, QC |
| 35 | Sun Dec 21 | vsCanadiens | 7:00 PM | 6-2-0 | 12 PTS | PPG Paints Arena · Pittsburgh, PA |
| 36 | Tue Dec 23 | atMaple Leafs | 4:00 PM | 3-3-1 | 7 PTS | Scotiabank Arena · Toronto, ON |
| 37 | Sun Dec 28 | atBlackhawks | 7:00 PM | 3-2-2 | 8 PTS | United Center · Chicago, IL |
| 38 | Tue Dec 30 | vsHurricanes | 7:00 PM | 5-1-0 | 10 PTS | PPG Paints Arena · Pittsburgh, PA |
| 39 | Thu Jan 1 | vsRed Wings | 7:00 PM | 5-2-0 | 10 PTS | PPG Paints Arena · Pittsburgh, PA |
| 40 | Sat Jan 3 | atRed Wings | 12:00 PM | 5-2-0 | 10 PTS | Little Caesars Arena · Detroit, MI |
| 41 | Sun Jan 4 | atJackets | 3:00 PM | 3-3-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 42 | Thu Jan 8 | vsDevils | 7:00 PM | 6-1-0 | 12 PTS | PPG Paints Arena · Pittsburgh, PA |
| 43 | Sat Jan 10 | vsFlames | 3:30 PM | 1-6-1 | 3 PTS | PPG Paints Arena · Pittsburgh, PA |
| 44 | Sun Jan 11 | atBruins | 5:00 PM | 3-5-0 | 6 PTS | TD Garden · Boston, MA |
| 45 | Tue Jan 13 | vsLightning | 7:00 PM | 1-3-2 | 4 PTS | PPG Paints Arena · Pittsburgh, PA |
| 46 | Thu Jan 15 | vsFlyers | 7:00 PM | 3-2-1 | 7 PTS | PPG Paints Arena · Pittsburgh, PA |
| 47 | Sat Jan 17 | vsJackets | 7:00 PM | 3-3-0 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 48 | Mon Jan 19 | atKraken | 5:00 PM | 3-2-2 | 8 PTS | Climate Pledge Arena · Seattle, WA |
| 49 | Wed Jan 21 | atFlames | 9:30 PM | 1-6-1 | 3 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 50 | Thu Jan 22 | atOilers | 9:00 PM | 3-3-1 | 7 PTS | Rogers Place · Edmonton, AB |
| 51 | Sun Jan 25 | atCanucks | 6:00 PM | 4-3-0 | 8 PTS | Rogers Arena · Vancouver, British Columbia |
| 52 | Thu Jan 29 | vsBlackhawks | 7:00 PM | 3-2-2 | 8 PTS | PPG Paints Arena · Pittsburgh, PA |
| 53 | Sat Jan 31 | vsRangers | 3:30 PM | 3-4-1 | 7 PTS | PPG Paints Arena · Pittsburgh, PA |
| 54 | Mon Feb 2 | vsSenators | 7:00 PM | 2-4-1 | 5 PTS | PPG Paints Arena · Pittsburgh, PA |
| 55 | Tue Feb 3 | atIslanders | 7:30 PM | 3-3-0 | 6 PTS | UBS Arena · Elmont, NY |
| 56 | Thu Feb 5 | atSabres | 7:00 PM | 3-4-0 | 6 PTS | KeyBank Center · Buffalo, NY |
| 57 | Thu Feb 26 | vsDevils | 7:00 PM | 6-1-0 | 12 PTS | PPG Paints Arena · Pittsburgh, PA |
| 58 | Sat Feb 28 | atRangers | 12:30 PM | 3-4-1 | 7 PTS | Madison Square Garden · Manhattan, NY |
| 59 | Sun Mar 1 | vsKnights | 1:00 PM | 5-0-2 | 12 PTS | PPG Paints Arena · Pittsburgh, PA |
| 60 | Tue Mar 3 | atBruins | 7:00 PM | 3-5-0 | 6 PTS | TD Garden · Boston, MA |
| 61 | Thu Mar 5 | vsSabres | 7:00 PM | 3-4-0 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 62 | Sat Mar 7 | vsFlyers | 5:30 PM | 3-2-1 | 7 PTS | PPG Paints Arena · Pittsburgh, PA |
| 63 | Sun Mar 8 | vsBruins | 4:30 PM | 3-5-0 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 64 | Tue Mar 10 | atHurricanes | 7:00 PM | 5-1-0 | 10 PTS | PNC Arena · Raleigh, NC |
| 65 | Thu Mar 12 | atKnights | 10:00 PM | 5-0-2 | 12 PTS | T-Mobile Arena · Las Vegas, NV |
| 66 | Sat Mar 14 | atMammoth | 9:00 PM | 5-2-0 | 10 PTS | Delta Center · Salt Lake City, UT |
| 67 | Mon Mar 16 | atAvalanche | 9:30 PM | 5-0-2 | 12 PTS | Ball Arena · Denver, CO |
| 68 | Wed Mar 18 | atHurricanes | 7:00 PM | 5-1-0 | 10 PTS | PNC Arena · Raleigh, NC |
| 69 | Sat Mar 21 | vsJets | 1:00 PM | 5-1-0 | 10 PTS | PPG Paints Arena · Pittsburgh, PA |
| 70 | Sun Mar 22 | vsHurricanes | 3:00 PM | 5-1-0 | 10 PTS | PPG Paints Arena · Pittsburgh, PA |
| 71 | Tue Mar 24 | vsAvalanche | 7:00 PM | 5-0-2 | 12 PTS | PPG Paints Arena · Pittsburgh, PA |
| 72 | Thu Mar 26 | atSenators | 7:00 PM | 2-4-1 | 5 PTS | Canadian Tire Centre · Ottawa, ON |
| 73 | Sat Mar 28 | vsStars | 5:00 PM | 3-3-0 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 74 | Mon Mar 30 | atIslanders | 7:00 PM | 3-3-0 | 6 PTS | UBS Arena · Elmont, NY |
| 75 | Tue Mar 31 | vsRed Wings | 7:00 PM | 5-2-0 | 10 PTS | PPG Paints Arena · Pittsburgh, PA |
| 76 | Thu Apr 2 | atLightning | 7:00 PM | 1-3-2 | 4 PTS | AMALIE Arena · Tampa, FL |
| 77 | Sat Apr 4 | vsPanthers | 5:00 PM | 4-4-0 | 8 PTS | PPG Paints Arena · Pittsburgh, PA |
| 78 | Sun Apr 5 | vsPanthers | 3:00 PM | 4-4-0 | 8 PTS | PPG Paints Arena · Pittsburgh, PA |
| 79 | Thu Apr 9 | atDevils | 7:00 PM | 6-1-0 | 12 PTS | Prudential Center · Newark, NJ |
| 80 | Sat Apr 11 | vsCapitals | 3:00 PM | 5-2-0 | 10 PTS | PPG Paints Arena · Pittsburgh, PA |
| 81 | Sun Apr 12 | atCapitals | 3:00 PM | 5-2-0 | 10 PTS | Capital One Arena · Washington, D.C. |
| 82 | Tue Apr 14 | atBlues | 9:30 PM | 3-2-1 | 7 PTS | Enterprise Center · St. Louis, MO |
