| 1 | Wed Jan 13 | at Flyers | L3-6 | 0-1-0 | 0 PTS | Wells Fargo Center · Philadelphia, PA |
| 2 | Fri Jan 15 | atFlyers | L2-5 | 0-2-0 | 0 PTS | Wells Fargo Center · Philadelphia, PA |
| 3 | Sun Jan 17 | vsCapitals | W4-3 (SO) | 1-2-0 | 2 PTS | PPG Paints Arena · Pittsburgh, PA |
| 4 | Tue Jan 19 | vsCapitals | W5-4 (OT) | 2-2-0 | 4 PTS | PPG Paints Arena · Pittsburgh, PA |
| 5 | Fri Jan 22 | vsRangers | W4-3 (SO) | 3-2-0 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 6 | Sun Jan 24 | vsRangers | W3-2 | 4-2-0 | 8 PTS | PPG Paints Arena · Pittsburgh, PA |
| 7 | Tue Jan 26 | atBruins | L2-3 (OT) | 4-2-1 | 9 PTS | TD Garden · Boston, MA |
| 8 | Thu Jan 28 | atBruins | L1-4 | 4-3-1 | 9 PTS | TD Garden · Boston, MA |
| 9 | Sat Jan 30 | atRangers | W5-4 (OT) | 5-3-1 | 11 PTS | Madison Square Garden · Manhattan, NY |
| 10 | Mon Feb 1 | atRangers | L1-3 | 5-4-1 | 11 PTS | Madison Square Garden · Manhattan, NY |
| 11 | Sat Feb 6 | atIslanders | L3-4 | 5-5-1 | 11 PTS | UBS Arena · Elmont, NY |
| 12 | Thu Feb 11 | atIslanders | W4-3 (SO) | 6-5-1 | 13 PTS | UBS Arena · Elmont, NY |
| 13 | Sun Feb 14 | vsCapitals | W6-3 | 7-5-1 | 15 PTS | PPG Paints Arena · Pittsburgh, PA |
| 14 | Tue Feb 16 | vsCapitals | L1-3 | 7-6-1 | 15 PTS | PPG Paints Arena · Pittsburgh, PA |
| 15 | Thu Feb 18 | vsIslanders | W4-1 | 8-6-1 | 17 PTS | PPG Paints Arena · Pittsburgh, PA |
| 16 | Sat Feb 20 | vsIslanders | W3-2 | 9-6-1 | 19 PTS | PPG Paints Arena · Pittsburgh, PA |
| 17 | Tue Feb 23 | atCapitals | W3-2 (OT) | 10-6-1 | 21 PTS | Capital One Arena · Washington, D.C. |
| 18 | Thu Feb 25 | atCapitals | L2-5 | 10-7-1 | 21 PTS | Capital One Arena · Washington, D.C. |
| 19 | Sat Feb 27 | atIslanders | W4-3 (OT) | 11-7-1 | 23 PTS | UBS Arena · Elmont, NY |
| 20 | Sun Feb 28 | atIslanders | L0-2 | 11-8-1 | 23 PTS | UBS Arena · Elmont, NY |
| 21 | Tue Mar 2 | vsFlyers | W5-2 | 12-8-1 | 25 PTS | PPG Paints Arena · Pittsburgh, PA |
| 22 | Thu Mar 4 | vsFlyers | L3-4 | 12-9-1 | 25 PTS | PPG Paints Arena · Pittsburgh, PA |
| 23 | Sat Mar 6 | vsFlyers | W4-3 | 13-9-1 | 27 PTS | PPG Paints Arena · Pittsburgh, PA |
| 24 | Sun Mar 7 | vsRangers | W5-1 | 14-9-1 | 29 PTS | PPG Paints Arena · Pittsburgh, PA |
| 25 | Tue Mar 9 | vsRangers | W4-2 | 15-9-1 | 31 PTS | PPG Paints Arena · Pittsburgh, PA |
| 26 | Thu Mar 11 | atSabres | W5-2 | 16-9-1 | 33 PTS | KeyBank Center · Buffalo, NY |
| 27 | Sat Mar 13 | atSabres | W3-0 | 17-9-1 | 35 PTS | KeyBank Center · Buffalo, NY |
| 28 | Mon Mar 15 | vsBruins | W4-1 | 18-9-1 | 37 PTS | PPG Paints Arena · Pittsburgh, PA |
| 29 | Tue Mar 16 | vsBruins | L1-2 | 18-10-1 | 37 PTS | PPG Paints Arena · Pittsburgh, PA |
| 30 | Thu Mar 18 | atDevils | L2-3 | 18-11-1 | 37 PTS | Prudential Center · Newark, NJ |
| 31 | Sat Mar 20 | atDevils | W3-1 | 19-11-1 | 39 PTS | Prudential Center · Newark, NJ |
| 32 | Sun Mar 21 | vsDevils | L1-2 (OT) | 19-11-2 | 40 PTS | PPG Paints Arena · Pittsburgh, PA |
| 33 | Wed Mar 24 | vsSabres | W5-2 | 20-11-2 | 42 PTS | PPG Paints Arena · Pittsburgh, PA |
| 34 | Thu Mar 25 | vsSabres | W4-0 | 21-11-2 | 44 PTS | PPG Paints Arena · Pittsburgh, PA |
| 35 | Sat Mar 27 | vsIslanders | W6-3 | 22-11-2 | 46 PTS | PPG Paints Arena · Pittsburgh, PA |
| 36 | Mon Mar 29 | vsIslanders | W2-1 | 23-11-2 | 48 PTS | PPG Paints Arena · Pittsburgh, PA |
| 37 | Thu Apr 1 | atBruins | W4-1 | 24-11-2 | 50 PTS | TD Garden · Boston, MA |
| 38 | Sat Apr 3 | atBruins | L5-7 | 24-12-2 | 50 PTS | TD Garden · Boston, MA |
| 39 | Tue Apr 6 | atRangers | L4-8 | 24-13-2 | 50 PTS | Madison Square Garden · Manhattan, NY |
| 40 | Thu Apr 8 | atRangers | W5-2 | 25-13-2 | 52 PTS | Madison Square Garden · Manhattan, NY |
| 41 | Fri Apr 9 | atDevils | W6-4 | 26-13-2 | 54 PTS | Prudential Center · Newark, NJ |
| 42 | Sun Apr 11 | atDevils | W5-2 | 27-13-2 | 56 PTS | Prudential Center · Newark, NJ |
| 43 | Thu Apr 15 | vsFlyers | L1-2 (SO) | 27-13-3 | 57 PTS | PPG Paints Arena · Pittsburgh, PA |
| 44 | Sat Apr 17 | atSabres | W3-2 | 28-13-3 | 59 PTS | KeyBank Center · Buffalo, NY |
| 45 | Sun Apr 18 | atSabres | L2-4 | 28-14-3 | 59 PTS | KeyBank Center · Buffalo, NY |
| 46 | Tue Apr 20 | vsDevils | W7-6 | 29-14-3 | 61 PTS | PPG Paints Arena · Pittsburgh, PA |
| 47 | Thu Apr 22 | vsDevils | W5-1 | 30-14-3 | 63 PTS | PPG Paints Arena · Pittsburgh, PA |
| 48 | Sat Apr 24 | vsDevils | W4-2 | 31-14-3 | 65 PTS | PPG Paints Arena · Pittsburgh, PA |
| 49 | Sun Apr 25 | vsBruins | W1-0 | 32-14-3 | 67 PTS | PPG Paints Arena · Pittsburgh, PA |
| 50 | Tue Apr 27 | vsBruins | L1-3 | 32-15-3 | 67 PTS | PPG Paints Arena · Pittsburgh, PA |
| 51 | Thu Apr 29 | atCapitals | W5-4 (OT) | 33-15-3 | 69 PTS | Capital One Arena · Washington, D.C. |
| 52 | Sat May 1 | atCapitals | W3-0 | 34-15-3 | 71 PTS | Capital One Arena · Washington, D.C. |
| 53 | Mon May 3 | atFlyers | L2-7 | 34-16-3 | 71 PTS | Wells Fargo Center · Philadelphia, PA |
| 54 | Tue May 4 | atFlyers | W7-3 | 35-16-3 | 73 PTS | Wells Fargo Center · Philadelphia, PA |
| 55 | Thu May 6 | vsSabres | W8-4 | 36-16-3 | 75 PTS | PPG Paints Arena · Pittsburgh, PA |
| 56 | Sat May 8 | vsSabres | W1-0 | 37-16-3 | 77 PTS | PPG Paints Arena · Pittsburgh, PA |
| 1 | Sun May 16 | vsIslanders | L3-4 (OT) | 0-1 | .000 | PPG Paints Arena · Pittsburgh, PA |
| 2 | Tue May 18 | vsIslanders | W2-1 | 1-1 | .500 | PPG Paints Arena · Pittsburgh, PA |
| 3 | Thu May 20 | atIslanders | W5-4 | 2-1 | .667 | UBS Arena · Elmont, NY |
| 4 | Sat May 22 | atIslanders | L1-4 | 2-2 | .500 | UBS Arena · Elmont, NY |
| 5 | Mon May 24 | vsIslanders | L2-3 (OT) | 2-3 | .400 | PPG Paints Arena · Pittsburgh, PA |
| 6 | Wed May 26 | atIslanders | L3-5 | 2-4 | .333 | UBS Arena · Elmont, NY |
