| 1 | Thu Oct 1 | at Jackets | 7:00 PM | 40-30-12 | 92 PTS | Nationwide Arena · Columbus, OH |
| 2 | Sat Oct 3 | vsBlackhawks | 7:00 PM | 29-39-14 | 72 PTS | KeyBank Center · Buffalo, NY |
| 3 | Tue Oct 6 | vsWild | 7:00 PM | 46-24-12 | 104 PTS | KeyBank Center · Buffalo, NY |
| 4 | Thu Oct 8 | vsStars | 7:00 PM | 50-20-12 | 112 PTS | KeyBank Center · Buffalo, NY |
| 5 | Sat Oct 10 | vsMammoth | 7:00 PM | 43-33-6 | 92 PTS | KeyBank Center · Buffalo, NY |
| 6 | Mon Oct 12 | vsPanthers | 1:00 PM | 40-38-4 | 84 PTS | KeyBank Center · Buffalo, NY |
| 7 | Tue Oct 13 | atCanadiens | 6:30 PM | 48-24-10 | 106 PTS | Bell Centre · Montreal, QC |
| 8 | Thu Oct 15 | atMaple Leafs | 7:00 PM | 32-36-14 | 78 PTS | Scotiabank Arena · Toronto, ON |
| 9 | Sat Oct 17 | atCanadiens | 7:00 PM | 48-24-10 | 106 PTS | Bell Centre · Montreal, QC |
| 10 | Wed Oct 21 | vsFlyers | 7:30 PM | 43-27-12 | 98 PTS | KeyBank Center · Buffalo, NY |
| 11 | Sat Oct 24 | atCapitals | 7:00 PM | 43-30-9 | 95 PTS | Capital One Arena · Washington, D.C. |
| 12 | Tue Oct 27 | atSharks | 10:30 PM | 39-35-8 | 86 PTS | SAP Center · San Jose, CA |
| 13 | Thu Oct 29 | atDucks | 10:00 PM | 43-33-6 | 92 PTS | Honda Center · Anaheim, CA |
| 14 | Sat Oct 31 | atKings | 4:00 PM | 35-27-20 | 90 PTS | Crypto.com Arena · Los Angeles, CA |
| 15 | Wed Nov 4 | vsSenators | 7:30 PM | 44-27-11 | 99 PTS | KeyBank Center · Buffalo, NY |
| 16 | Fri Nov 6 | vsJackets | 7:00 PM | 40-30-12 | 92 PTS | KeyBank Center · Buffalo, NY |
| 17 | Sun Nov 8 | vsKnights | 3:30 PM | 39-26-17 | 95 PTS | KeyBank Center · Buffalo, NY |
| 18 | Wed Nov 11 | vsLightning | 7:00 PM | 50-26-6 | 106 PTS | KeyBank Center · Buffalo, NY |
| 19 | Thu Nov 12 | atBlackhawks | 8:00 PM | 29-39-14 | 72 PTS | United Center · Chicago, IL |
| 20 | Sat Nov 14 | atStars | 8:00 PM | 50-20-12 | 112 PTS | American Airlines Center · Dallas, TX |
| 21 | Tue Nov 17 | atFlyers | 7:00 PM | 43-27-12 | 98 PTS | Xfinity Mobile Arena · Philadelphia, PA |
| 22 | Thu Nov 19 | atCapitals | 7:00 PM | 43-30-9 | 95 PTS | Capital One Arena · Washington, D.C. |
| 23 | Sat Nov 21 | atPanthers | 6:00 PM | 40-38-4 | 84 PTS | Amerant Bank Arena · Sunrise, FL |
| 24 | Sun Nov 22 | atLightning | 5:00 PM | 50-26-6 | 106 PTS | Benchmark International Arena · Tampa, FL |
| 25 | Wed Nov 25 | vsRangers | 7:00 PM | 34-39-9 | 77 PTS | KeyBank Center · Buffalo, NY |
| 26 | Fri Nov 27 | vsPenguins | 8:00 PM | 41-25-16 | 98 PTS | KeyBank Center · Buffalo, NY |
| 27 | Tue Dec 1 | atOilers | 8:00 PM | 41-30-11 | 93 PTS | Rogers Place · Edmonton, AB |
| 28 | Thu Dec 3 | atFlames | 8:00 PM | 34-39-9 | 77 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 29 | Fri Dec 4 | atCanucks | 9:00 PM | 25-49-8 | 58 PTS | Rogers Arena · Vancouver, British Columbia |
| 30 | Sun Dec 6 | atKraken | 8:00 PM | 34-37-11 | 79 PTS | Climate Pledge Arena · Seattle, WA |
| 31 | Thu Dec 10 | vsOilers | 7:00 PM | 41-30-11 | 93 PTS | KeyBank Center · Buffalo, NY |
| 32 | Sat Dec 12 | vsDucks | 7:00 PM | 43-33-6 | 92 PTS | KeyBank Center · Buffalo, NY |
| 33 | Mon Dec 14 | atSenators | 2:00 PM | 44-27-11 | 99 PTS | Canadian Tire Centre · Ottawa, ON |
| 34 | Tue Dec 15 | vsFlames | 7:00 PM | 34-39-9 | 77 PTS | KeyBank Center · Buffalo, NY |
| 35 | Fri Dec 18 | vsCanadiens | 7:30 PM | 48-24-10 | 106 PTS | KeyBank Center · Buffalo, NY |
| 36 | Sun Dec 20 | vsKings | 6:00 PM | 35-27-20 | 90 PTS | KeyBank Center · Buffalo, NY |
| 37 | Tue Dec 22 | atPenguins | 7:00 PM | 41-25-16 | 98 PTS | PPG Paints Arena · Pittsburgh, PA |
| 38 | Sat Dec 26 | vsDevils | 7:00 PM | 42-37-3 | 87 PTS | KeyBank Center · Buffalo, NY |
| 39 | Mon Dec 28 | vsRed Wings | 7:00 PM | 41-31-10 | 92 PTS | KeyBank Center · Buffalo, NY |
| 40 | Wed Dec 30 | atPanthers | 7:00 PM | 40-38-4 | 84 PTS | Amerant Bank Arena · Sunrise, FL |
| 41 | Sat Jan 2 | atLightning | 7:00 PM | 50-26-6 | 106 PTS | Benchmark International Arena · Tampa, FL |
| 42 | Mon Jan 4 | vsJets | 7:30 PM | 35-35-12 | 82 PTS | KeyBank Center · Buffalo, NY |
| 43 | Tue Jan 5 | atBruins | 7:30 PM | 45-27-10 | 100 PTS | TD Garden · Boston, MA |
| 44 | Fri Jan 8 | atJackets | 7:00 PM | 40-30-12 | 92 PTS | Nationwide Arena · Columbus, OH |
| 45 | Sat Jan 9 | vsHurricanes | 7:00 PM | 53-22-7 | 113 PTS | KeyBank Center · Buffalo, NY |
| 46 | Tue Jan 12 | vsDevils | 7:00 PM | 42-37-3 | 87 PTS | KeyBank Center · Buffalo, NY |
| 47 | Thu Jan 14 | vsAvalanche | 7:30 PM | 55-16-11 | 121 PTS | KeyBank Center · Buffalo, NY |
| 48 | Sat Jan 16 | vsPredators | 7:00 PM | 38-34-10 | 86 PTS | KeyBank Center · Buffalo, NY |
| 49 | Mon Jan 18 | vsCanadiens | 2:00 PM | 48-24-10 | 106 PTS | KeyBank Center · Buffalo, NY |
| 50 | Wed Jan 20 | atIslanders | 7:00 PM | 43-34-5 | 91 PTS | UBS Arena · Elmont, NY |
| 51 | Thu Jan 21 | vsKraken | 7:00 PM | 34-37-11 | 79 PTS | KeyBank Center · Buffalo, NY |
| 52 | Sun Jan 24 | atJets | 3:00 PM | 35-35-12 | 82 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 53 | Wed Jan 27 | atMammoth | 9:00 PM | 43-33-6 | 92 PTS | Delta Center · Salt Lake City, UT |
| 54 | Thu Jan 28 | atKnights | 10:00 PM | 39-26-17 | 95 PTS | T-Mobile Arena · Las Vegas, NV |
| 55 | Sat Jan 30 | atAvalanche | 5:00 PM | 55-16-11 | 121 PTS | Ball Arena · Denver, CO |
| 56 | Wed Feb 3 | vsIslanders | 7:00 PM | 43-34-5 | 91 PTS | KeyBank Center · Buffalo, NY |
| 57 | Sat Feb 13 | atHurricanes | 7:00 PM | 53-22-7 | 113 PTS | PNC Arena · Raleigh, NC |
| 58 | Mon Feb 15 | atRangers | 6:00 PM | 34-39-9 | 77 PTS | Madison Square Garden · Manhattan, NY |
| 59 | Thu Feb 18 | vsHurricanes | 7:00 PM | 53-22-7 | 113 PTS | KeyBank Center · Buffalo, NY |
| 60 | Sat Feb 20 | atDevils | 1:30 PM | 42-37-3 | 87 PTS | Prudential Center · Newark, NJ |
| 61 | Sun Feb 21 | atRed Wings | 3:30 PM | 41-31-10 | 92 PTS | Little Caesars Arena · Detroit, MI |
| 62 | Wed Feb 24 | atFlyers | 7:00 PM | 43-27-12 | 98 PTS | Xfinity Mobile Arena · Philadelphia, PA |
| 63 | Fri Feb 26 | vsSenators | 7:30 PM | 44-27-11 | 99 PTS | KeyBank Center · Buffalo, NY |
| 64 | Sat Feb 27 | vsMaple Leafs | 7:00 PM | 32-36-14 | 78 PTS | KeyBank Center · Buffalo, NY |
| 65 | Tue Mar 2 | vsPenguins | 7:00 PM | 41-25-16 | 98 PTS | KeyBank Center · Buffalo, NY |
| 66 | Thu Mar 4 | vsBlues | 7:00 PM | 37-33-12 | 86 PTS | KeyBank Center · Buffalo, NY |
| 67 | Sat Mar 6 | vsRangers | 3:00 PM | 34-39-9 | 77 PTS | KeyBank Center · Buffalo, NY |
| 68 | Sun Mar 7 | atSenators | 3:00 PM | 44-27-11 | 99 PTS | Canadian Tire Centre · Ottawa, ON |
| 69 | Tue Mar 9 | vsCanucks | 7:00 PM | 25-49-8 | 58 PTS | KeyBank Center · Buffalo, NY |
| 70 | Fri Mar 12 | atRed Wings | 7:00 PM | 41-31-10 | 92 PTS | Little Caesars Arena · Detroit, MI |
| 71 | Sun Mar 14 | atWild | 7:00 PM | 46-24-12 | 104 PTS | Xcel Energy Center · St. Paul, MN |
| 72 | Mon Mar 15 | vsSharks | 7:00 PM | 39-35-8 | 86 PTS | KeyBank Center · Buffalo, NY |
| 73 | Thu Mar 18 | vsCapitals | 7:30 PM | 43-30-9 | 95 PTS | KeyBank Center · Buffalo, NY |
| 74 | Sat Mar 20 | vsPanthers | 1:00 PM | 40-38-4 | 84 PTS | KeyBank Center · Buffalo, NY |
| 75 | Sun Mar 21 | atIslanders | 3:00 PM | 43-34-5 | 91 PTS | UBS Arena · Elmont, NY |
| 76 | Tue Mar 23 | atBruins | 7:00 PM | 45-27-10 | 100 PTS | TD Garden · Boston, MA |
| 77 | Thu Mar 25 | vsMaple Leafs | 7:00 PM | 32-36-14 | 78 PTS | KeyBank Center · Buffalo, NY |
| 78 | Sun Mar 28 | atBlues | 8:30 PM | 37-33-12 | 86 PTS | Enterprise Center · St. Louis, MO |
| 79 | Tue Mar 30 | atPredators | 8:00 PM | 38-34-10 | 86 PTS | Bridgestone Arena · Nashville, TN |
| 80 | Thu Apr 1 | vsBruins | 7:00 PM | 45-27-10 | 100 PTS | KeyBank Center · Buffalo, NY |
| 81 | Sat Apr 3 | atMaple Leafs | 7:00 PM | 32-36-14 | 78 PTS | Scotiabank Arena · Toronto, ON |
| 82 | Mon Apr 5 | vsLightning | 7:00 PM | 50-26-6 | 106 PTS | KeyBank Center · Buffalo, NY |
| 83 | Wed Apr 7 | vsBruins | 7:30 PM | 45-27-10 | 100 PTS | KeyBank Center · Buffalo, NY |
| 84 | Sat Apr 10 | vsRed Wings | 6:00 PM | 41-31-10 | 92 PTS | KeyBank Center · Buffalo, NY |
