| 1 | Thu Jan 14 | vs Capitals | L4-6 | 0-1-0 | 0 PTS | KeyBank Center · Buffalo, NY |
| 2 | Fri Jan 15 | vsCapitals | L1-2 | 0-2-0 | 0 PTS | KeyBank Center · Buffalo, NY |
| 3 | Mon Jan 18 | atFlyers | W6-1 | 1-2-0 | 2 PTS | Wells Fargo Center · Philadelphia, PA |
| 4 | Tue Jan 19 | atFlyers | L0-3 | 1-3-0 | 2 PTS | Wells Fargo Center · Philadelphia, PA |
| 5 | Fri Jan 22 | atCapitals | L3-4 (SO) | 1-3-1 | 3 PTS | Capital One Arena · Washington, D.C. |
| 6 | Sun Jan 24 | atCapitals | W4-3 (SO) | 2-3-1 | 5 PTS | Capital One Arena · Washington, D.C. |
| 7 | Tue Jan 26 | vsRangers | W3-2 | 3-3-1 | 7 PTS | KeyBank Center · Buffalo, NY |
| 8 | Thu Jan 28 | vsRangers | L2-3 (OT) | 3-3-2 | 8 PTS | KeyBank Center · Buffalo, NY |
| 9 | Sat Jan 30 | vsDevils | W4-3 (SO) | 4-3-2 | 10 PTS | KeyBank Center · Buffalo, NY |
| 10 | Sun Jan 31 | vsDevils | L3-5 | 4-4-2 | 10 PTS | KeyBank Center · Buffalo, NY |
| 11 | Mon Feb 15 | vsIslanders | L1-3 | 4-5-2 | 10 PTS | KeyBank Center · Buffalo, NY |
| 12 | Tue Feb 16 | vsIslanders | L0-3 | 4-6-2 | 10 PTS | KeyBank Center · Buffalo, NY |
| 13 | Thu Feb 18 | atCapitals | L1-3 | 4-7-2 | 10 PTS | Capital One Arena · Washington, D.C. |
| 14 | Sat Feb 20 | atDevils | W3-2 | 5-7-2 | 12 PTS | Prudential Center · Newark, NJ |
| 15 | Mon Feb 22 | atIslanders | L2-3 | 5-8-2 | 12 PTS | UBS Arena · Elmont, NY |
| 16 | Tue Feb 23 | atDevils | W4-1 | 6-8-2 | 14 PTS | Prudential Center · Newark, NJ |
| 17 | Thu Feb 25 | vsDevils | L3-4 (OT) | 6-8-3 | 15 PTS | KeyBank Center · Buffalo, NY |
| 18 | Sat Feb 27 | vsFlyers | L0-3 | 6-9-3 | 15 PTS | KeyBank Center · Buffalo, NY |
| 19 | Sun Feb 28 | vsFlyers | L0-3 | 6-10-3 | 15 PTS | KeyBank Center · Buffalo, NY |
| 20 | Tue Mar 2 | atRangers | L2-3 | 6-11-3 | 15 PTS | Madison Square Garden · Manhattan, NY |
| 21 | Thu Mar 4 | atIslanders | L2-5 | 6-12-3 | 15 PTS | UBS Arena · Elmont, NY |
| 22 | Sat Mar 6 | atIslanders | L2-5 | 6-13-3 | 15 PTS | UBS Arena · Elmont, NY |
| 23 | Sun Mar 7 | atIslanders | L2-5 | 6-14-3 | 15 PTS | UBS Arena · Elmont, NY |
| 24 | Tue Mar 9 | atFlyers | L4-5 (SO) | 6-14-4 | 16 PTS | Wells Fargo Center · Philadelphia, PA |
| 25 | Thu Mar 11 | vsPenguins | L2-5 | 6-15-4 | 16 PTS | KeyBank Center · Buffalo, NY |
| 26 | Sat Mar 13 | vsPenguins | L0-3 | 6-16-4 | 16 PTS | KeyBank Center · Buffalo, NY |
| 27 | Mon Mar 15 | vsCapitals | L0-6 | 6-17-4 | 16 PTS | KeyBank Center · Buffalo, NY |
| 28 | Tue Mar 16 | atDevils | L2-3 | 6-18-4 | 16 PTS | Prudential Center · Newark, NJ |
| 29 | Thu Mar 18 | vsBruins | L1-4 | 6-19-4 | 16 PTS | KeyBank Center · Buffalo, NY |
| 30 | Mon Mar 22 | atRangers | L3-5 | 6-20-4 | 16 PTS | Madison Square Garden · Manhattan, NY |
| 31 | Wed Mar 24 | atPenguins | L2-5 | 6-21-4 | 16 PTS | PPG Paints Arena · Pittsburgh, PA |
| 32 | Thu Mar 25 | atPenguins | L0-4 | 6-22-4 | 16 PTS | PPG Paints Arena · Pittsburgh, PA |
| 33 | Sat Mar 27 | atBruins | L2-3 | 6-23-4 | 16 PTS | TD Garden · Boston, MA |
| 34 | Mon Mar 29 | vsFlyers | L3-4 (OT) | 6-23-5 | 17 PTS | KeyBank Center · Buffalo, NY |
| 35 | Wed Mar 31 | vsFlyers | W6-1 | 7-23-5 | 19 PTS | KeyBank Center · Buffalo, NY |
| 36 | Thu Apr 1 | vsRangers | L2-3 (OT) | 7-23-6 | 20 PTS | KeyBank Center · Buffalo, NY |
| 37 | Sat Apr 3 | vsRangers | W3-2 (SO) | 8-23-6 | 22 PTS | KeyBank Center · Buffalo, NY |
| 38 | Tue Apr 6 | atDevils | W5-3 | 9-23-6 | 24 PTS | Prudential Center · Newark, NJ |
| 39 | Thu Apr 8 | vsDevils | L3-6 | 9-24-6 | 24 PTS | KeyBank Center · Buffalo, NY |
| 40 | Fri Apr 9 | vsCapitals | L3-4 | 9-25-6 | 24 PTS | KeyBank Center · Buffalo, NY |
| 41 | Sun Apr 11 | atFlyers | W5-3 | 10-25-6 | 26 PTS | Wells Fargo Center · Philadelphia, PA |
| 42 | Tue Apr 13 | atBruins | L2-3 (SO) | 10-25-7 | 27 PTS | TD Garden · Boston, MA |
| 43 | Thu Apr 15 | atCapitals | W5-2 | 11-25-7 | 29 PTS | Capital One Arena · Washington, D.C. |
| 44 | Sat Apr 17 | vsPenguins | L2-3 | 11-26-7 | 29 PTS | KeyBank Center · Buffalo, NY |
| 45 | Sun Apr 18 | vsPenguins | W4-2 | 12-26-7 | 31 PTS | KeyBank Center · Buffalo, NY |
| 46 | Tue Apr 20 | vsBruins | L0-2 | 12-27-7 | 31 PTS | KeyBank Center · Buffalo, NY |
| 47 | Thu Apr 22 | vsBruins | L1-5 | 12-28-7 | 31 PTS | KeyBank Center · Buffalo, NY |
| 48 | Fri Apr 23 | vsBruins | W6-4 | 13-28-7 | 33 PTS | KeyBank Center · Buffalo, NY |
| 49 | Sun Apr 25 | atRangers | L3-6 | 13-29-7 | 33 PTS | Madison Square Garden · Manhattan, NY |
| 50 | Tue Apr 27 | atRangers | L1-3 | 13-30-7 | 33 PTS | Madison Square Garden · Manhattan, NY |
| 51 | Thu Apr 29 | atBruins | L2-5 | 13-31-7 | 33 PTS | TD Garden · Boston, MA |
| 52 | Sat May 1 | atBruins | L2-6 | 13-32-7 | 33 PTS | TD Garden · Boston, MA |
| 53 | Mon May 3 | vsIslanders | W4-2 | 14-32-7 | 35 PTS | KeyBank Center · Buffalo, NY |
| 54 | Tue May 4 | vsIslanders | W4-3 (SO) | 15-32-7 | 37 PTS | KeyBank Center · Buffalo, NY |
| 55 | Thu May 6 | atPenguins | L4-8 | 15-33-7 | 37 PTS | PPG Paints Arena · Pittsburgh, PA |
| 56 | Sat May 8 | atPenguins | L0-1 | 15-34-7 | 37 PTS | PPG Paints Arena · Pittsburgh, PA |
