| 1 | Thu Oct 12 | vs Rangers | L1-5 | 0-1-0 | 0 PTS | KeyBank Center · Buffalo, NY |
| 2 | Sat Oct 14 | atIslanders | L2-3 | 0-2-0 | 0 PTS | UBS Arena · Elmont, NY |
| 3 | Tue Oct 17 | vsLightning | W3-2 (OT) | 1-2-0 | 2 PTS | KeyBank Center · Buffalo, NY |
| 4 | Thu Oct 19 | vsFlames | L3-4 | 1-3-0 | 2 PTS | KeyBank Center · Buffalo, NY |
| 5 | Sat Oct 21 | vsIslanders | W3-1 | 2-3-0 | 4 PTS | KeyBank Center · Buffalo, NY |
| 6 | Mon Oct 23 | vsCanadiens | L1-3 | 2-4-0 | 4 PTS | KeyBank Center · Buffalo, NY |
| 7 | Tue Oct 24 | atSenators | W6-4 | 3-4-0 | 6 PTS | Canadian Tire Centre · Ottawa, ON |
| 8 | Fri Oct 27 | atDevils | L4-5 | 3-5-0 | 6 PTS | Prudential Center · Newark, NJ |
| 9 | Sun Oct 29 | vsAvalanche | W4-0 | 4-5-0 | 8 PTS | KeyBank Center · Buffalo, NY |
| 10 | Wed Nov 1 | atFlyers | W5-2 | 5-5-0 | 10 PTS | Wells Fargo Center · Philadelphia, PA |
| 11 | Fri Nov 3 | vsFlyers | L1-5 | 5-6-0 | 10 PTS | KeyBank Center · Buffalo, NY |
| 12 | Sat Nov 4 | atMaple Leafs | W6-4 | 6-6-0 | 12 PTS | Scotiabank Arena · Toronto, ON |
| 13 | Tue Nov 7 | atHurricanes | L2-3 (OT) | 6-6-1 | 13 PTS | PNC Arena · Raleigh, NC |
| 14 | Fri Nov 10 | vsWild | W3-2 | 7-6-1 | 15 PTS | KeyBank Center · Buffalo, NY |
| 15 | Sat Nov 11 | atPenguins | L0-4 | 7-7-1 | 15 PTS | PPG Paints Arena · Pittsburgh, PA |
| 16 | Tue Nov 14 | vsBruins | L2-5 | 7-8-1 | 15 PTS | KeyBank Center · Buffalo, NY |
| 17 | Fri Nov 17 | atJets | L2-3 | 7-9-1 | 15 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 18 | Sun Nov 19 | atBlackhawks | W3-2 | 8-9-1 | 17 PTS | United Center · Chicago, IL |
| 19 | Wed Nov 22 | atCapitals | L3-4 (OT) | 8-9-2 | 18 PTS | Capital One Arena · Washington, D.C. |
| 20 | Fri Nov 24 | vsPenguins | W3-2 | 9-9-2 | 20 PTS | KeyBank Center · Buffalo, NY |
| 21 | Sat Nov 25 | atDevils | L2-7 | 9-10-2 | 20 PTS | Prudential Center · Newark, NJ |
| 22 | Mon Nov 27 | atRangers | W5-1 | 10-10-2 | 22 PTS | Madison Square Garden · Manhattan, NY |
| 23 | Thu Nov 30 | atBlues | L4-6 | 10-11-2 | 22 PTS | Enterprise Center · St. Louis, MO |
| 24 | Sat Dec 2 | atHurricanes | L2-6 | 10-12-2 | 22 PTS | PNC Arena · Raleigh, NC |
| 25 | Sun Dec 3 | vsPredators | L1-2 | 10-13-2 | 22 PTS | KeyBank Center · Buffalo, NY |
| 26 | Tue Dec 5 | vsRed Wings | L3-5 | 10-14-2 | 22 PTS | KeyBank Center · Buffalo, NY |
| 27 | Thu Dec 7 | atBruins | W3-1 | 11-14-2 | 24 PTS | TD Garden · Boston, MA |
| 28 | Sat Dec 9 | vsCanadiens | L2-3 (SO) | 11-14-3 | 25 PTS | KeyBank Center · Buffalo, NY |
| 29 | Mon Dec 11 | vsCoyotes | W5-2 | 12-14-3 | 27 PTS | KeyBank Center · Buffalo, NY |
| 30 | Wed Dec 13 | atAvalanche | L1-5 | 12-15-3 | 27 PTS | Ball Arena · Denver, CO |
| 31 | Fri Dec 15 | atKnights | W5-2 | 13-15-3 | 29 PTS | T-Mobile Arena · Las Vegas, NV |
| 32 | Sat Dec 16 | atCoyotes | L0-2 | 13-16-3 | 29 PTS | Mullett Arena · Tempe, AZ |
| 33 | Tue Dec 19 | vsJackets | L4-9 | 13-17-3 | 29 PTS | KeyBank Center · Buffalo, NY |
| 34 | Thu Dec 21 | vsMaple Leafs | W9-3 | 14-17-3 | 31 PTS | KeyBank Center · Buffalo, NY |
| 35 | Sat Dec 23 | atRangers | L3-4 (OT) | 14-17-4 | 32 PTS | Madison Square Garden · Manhattan, NY |
| 36 | Wed Dec 27 | vsBruins | L1-4 | 14-18-4 | 32 PTS | KeyBank Center · Buffalo, NY |
| 37 | Sat Dec 30 | vsJackets | W3-2 (OT) | 15-18-4 | 34 PTS | KeyBank Center · Buffalo, NY |
| 38 | Sun Dec 31 | atSenators | L1-5 | 15-19-4 | 34 PTS | Canadian Tire Centre · Ottawa, ON |
| 39 | Thu Jan 4 | atCanadiens | W6-1 | 16-19-4 | 36 PTS | Bell Centre · Montreal, QC |
| 40 | Sat Jan 6 | atPenguins | W3-1 | 17-19-4 | 38 PTS | PPG Paints Arena · Pittsburgh, PA |
| 41 | Tue Jan 9 | vsKraken | L2-5 | 17-20-4 | 38 PTS | KeyBank Center · Buffalo, NY |
| 42 | Thu Jan 11 | vsSenators | W5-3 | 18-20-4 | 40 PTS | KeyBank Center · Buffalo, NY |
| 43 | Sat Jan 13 | vsCanucks | L0-1 | 18-21-4 | 40 PTS | KeyBank Center · Buffalo, NY |
| 44 | Mon Jan 15 | vsSharks | W3-0 | 19-21-4 | 42 PTS | KeyBank Center · Buffalo, NY |
| 45 | Thu Jan 18 | vsBlackhawks | W3-0 | 20-21-4 | 44 PTS | KeyBank Center · Buffalo, NY |
| 46 | Sat Jan 20 | vsLightning | L1-3 | 20-22-4 | 44 PTS | KeyBank Center · Buffalo, NY |
| 47 | Tue Jan 23 | atDucks | L2-4 | 20-23-4 | 44 PTS | Honda Center · Anaheim, CA |
| 48 | Wed Jan 24 | atKings | W5-3 | 21-23-4 | 46 PTS | Crypto.com Arena · Los Angeles, CA |
| 49 | Sat Jan 27 | atSharks | W5-2 | 22-23-4 | 48 PTS | SAP Center · San Jose, CA |
| 50 | Tue Feb 6 | vsStars | L1-2 | 22-24-4 | 48 PTS | KeyBank Center · Buffalo, NY |
| 51 | Sat Feb 10 | vsBlues | L1-3 | 22-25-4 | 48 PTS | KeyBank Center · Buffalo, NY |
| 52 | Tue Feb 13 | vsKings | W7-0 | 23-25-4 | 50 PTS | KeyBank Center · Buffalo, NY |
| 53 | Thu Feb 15 | vsPanthers | L0-4 | 23-26-4 | 50 PTS | KeyBank Center · Buffalo, NY |
| 54 | Sat Feb 17 | atWild | W3-2 (OT) | 24-26-4 | 52 PTS | Xcel Energy Center · St. Paul, MN |
| 55 | Mon Feb 19 | vsDucks | L3-4 | 24-27-4 | 52 PTS | KeyBank Center · Buffalo, NY |
| 56 | Wed Feb 21 | atCanadiens | W3-2 | 25-27-4 | 54 PTS | Bell Centre · Montreal, QC |
| 57 | Fri Feb 23 | atJackets | W2-1 | 26-27-4 | 56 PTS | Nationwide Arena · Columbus, OH |
| 58 | Sun Feb 25 | vsHurricanes | W3-2 (SO) | 27-27-4 | 58 PTS | KeyBank Center · Buffalo, NY |
| 59 | Tue Feb 27 | atPanthers | L2-3 | 27-28-4 | 58 PTS | Amerant Bank Arena · Sunrise, FL |
| 60 | Thu Feb 29 | atLightning | W3-2 (OT) | 28-28-4 | 60 PTS | AMALIE Arena · Tampa, FL |
| 61 | Sat Mar 2 | vsKnights | W7-2 | 29-28-4 | 62 PTS | KeyBank Center · Buffalo, NY |
| 62 | Sun Mar 3 | vsJets | L2-5 | 29-29-4 | 62 PTS | KeyBank Center · Buffalo, NY |
| 63 | Wed Mar 6 | atMaple Leafs | L1-2 (OT) | 29-29-5 | 63 PTS | Scotiabank Arena · Toronto, ON |
| 64 | Thu Mar 7 | atPredators | L2-4 | 29-30-5 | 63 PTS | Bridgestone Arena · Nashville, TN |
| 65 | Sat Mar 9 | vsOilers | W3-2 (SO) | 30-30-5 | 65 PTS | KeyBank Center · Buffalo, NY |
| 66 | Tue Mar 12 | vsRed Wings | W7-3 | 31-30-5 | 67 PTS | KeyBank Center · Buffalo, NY |
| 67 | Thu Mar 14 | vsIslanders | W4-0 | 32-30-5 | 69 PTS | KeyBank Center · Buffalo, NY |
| 68 | Sat Mar 16 | atRed Wings | L1-4 | 32-31-5 | 69 PTS | Little Caesars Arena · Detroit, MI |
| 69 | Mon Mar 18 | atKraken | W6-2 | 33-31-5 | 71 PTS | Climate Pledge Arena · Seattle, WA |
| 70 | Tue Mar 19 | atCanucks | L2-3 | 33-32-5 | 71 PTS | Rogers Arena · Vancouver, British Columbia |
| 71 | Thu Mar 21 | atOilers | L3-8 | 33-33-5 | 71 PTS | Rogers Place · Edmonton, AB |
| 72 | Sun Mar 24 | atFlames | W4-1 | 34-33-5 | 73 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 73 | Wed Mar 27 | vsSenators | L2-6 | 34-34-5 | 73 PTS | KeyBank Center · Buffalo, NY |
| 74 | Fri Mar 29 | vsDevils | W5-2 | 35-34-5 | 75 PTS | KeyBank Center · Buffalo, NY |
| 75 | Sat Mar 30 | vsMaple Leafs | L0-3 | 35-35-5 | 75 PTS | KeyBank Center · Buffalo, NY |
| 76 | Tue Apr 2 | vsCapitals | W6-2 | 36-35-5 | 77 PTS | KeyBank Center · Buffalo, NY |
| 77 | Fri Apr 5 | vsFlyers | W4-2 | 37-35-5 | 79 PTS | KeyBank Center · Buffalo, NY |
| 78 | Sun Apr 7 | atRed Wings | L1-3 | 37-36-5 | 79 PTS | Little Caesars Arena · Detroit, MI |
| 79 | Tue Apr 9 | atStars | L2-3 | 37-37-5 | 79 PTS | American Airlines Center · Dallas, TX |
| 80 | Thu Apr 11 | vsCapitals | W4-2 | 38-37-5 | 81 PTS | KeyBank Center · Buffalo, NY |
| 81 | Sat Apr 13 | atPanthers | L2-3 (OT) | 38-37-6 | 82 PTS | Amerant Bank Arena · Sunrise, FL |
| 82 | Mon Apr 15 | atLightning | W4-2 | 39-37-6 | 84 PTS | AMALIE Arena · Tampa, FL |
