| 1 | Thu Oct 10 | at Sabres | W3-1 | 1-0-0 | 2 PTS | KeyBank Center · Buffalo, NY |
| 2 | Sat Oct 12 | at Bruins | L1-2 (OT) | 1-0-1 | 3 PTS | TD Garden · Boston, MA |
| 3 | Mon Oct 14 | at Senators | L7-8 (OT) | 1-0-2 | 4 PTS | Canadian Tire Centre · Ottawa, ON |
| 4 | Wed Oct 16 | at Maple Leafs | L2-6 | 1-1-2 | 4 PTS | Scotiabank Arena · Toronto, ON |
| 5 | Thu Oct 17 | at Canadiens | W4-1 | 2-1-2 | 6 PTS | Bell Centre · Montreal, QC |
| 6 | Sun Oct 20 | at Ducks | W4-1 | 3-1-2 | 8 PTS | Honda Center · Anaheim, CA |
| 7 | Tue Oct 22 | at Knights | L1-6 | 3-2-2 | 8 PTS | T-Mobile Arena · Las Vegas, NV |
| 8 | Thu Oct 24 | vs Sharks | W3-2 | 4-2-2 | 10 PTS | Crypto.com Arena · Los Angeles, CA |
| 9 | Sat Oct 26 | vs Utah HC | W3-2 | 5-2-2 | 12 PTS | Crypto.com Arena · Los Angeles, CA |
| 10 | Tue Oct 29 | atSharks | L2-4 | 5-3-2 | 12 PTS | SAP Center · San Jose, CA |
| 11 | Wed Oct 30 | vsKnights | W6-3 | 6-3-2 | 14 PTS | Crypto.com Arena · Los Angeles, CA |
| 12 | Sat Nov 2 | vs Blackhawks | L3-4 (SO) | 6-3-3 | 15 PTS | Crypto.com Arena · Los Angeles, CA |
| 13 | Mon Nov 4 | at Predators | W3-0 | 7-3-3 | 17 PTS | Bridgestone Arena · Nashville, TN |
| 14 | Tue Nov 5 | at Wild | W5-1 | 8-3-3 | 19 PTS | Xcel Energy Center · St. Paul, MN |
| 15 | Thu Nov 7 | vs Canucks | L2-4 | 8-4-3 | 19 PTS | Crypto.com Arena · Los Angeles, CA |
| 16 | Sat Nov 9 | vs Jackets | W5-2 | 9-4-3 | 21 PTS | Crypto.com Arena · Los Angeles, CA |
| 17 | Mon Nov 11 | at Flames | L1-3 | 9-5-3 | 21 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 18 | Wed Nov 13 | at Avalanche | L2-4 | 9-6-3 | 21 PTS | Ball Arena · Denver, CO |
| 19 | Sat Nov 16 | vs Red Wings | W4-1 | 10-6-3 | 23 PTS | Crypto.com Arena · Los Angeles, CA |
| 20 | Wed Nov 20 | vsSabres | L0-1 | 10-7-3 | 23 PTS | Crypto.com Arena · Los Angeles, CA |
| 21 | Sat Nov 23 | vs Kraken | W2-1 | 11-7-3 | 25 PTS | Crypto.com Arena · Los Angeles, CA |
| 22 | Mon Nov 25 | atSharks | L2-7 | 11-8-3 | 25 PTS | SAP Center · San Jose, CA |
| 23 | Wed Nov 27 | vs Jets | W4-1 | 12-8-3 | 27 PTS | Crypto.com Arena · Los Angeles, CA |
| 24 | Fri Nov 29 | atDucks | W2-1 | 13-8-3 | 29 PTS | Honda Center · Anaheim, CA |
| 25 | Sat Nov 30 | vsSenators | W5-2 | 14-8-3 | 31 PTS | Crypto.com Arena · Los Angeles, CA |
| 26 | Wed Dec 4 | vs Stars | W3-2 | 15-8-3 | 33 PTS | Crypto.com Arena · Los Angeles, CA |
| 27 | Sat Dec 7 | vsWild | W4-1 | 16-8-3 | 35 PTS | Crypto.com Arena · Los Angeles, CA |
| 28 | Tue Dec 10 | at Islanders | W3-1 | 17-8-3 | 37 PTS | UBS Arena · Elmont, NY |
| 29 | Thu Dec 12 | at Devils | L1-3 | 17-9-3 | 37 PTS | Prudential Center · Newark, NJ |
| 30 | Sat Dec 14 | at Rangers | W5-1 | 18-9-3 | 39 PTS | Madison Square Garden · Manhattan, NY |
| 31 | Tue Dec 17 | at Penguins | L2-3 (OT) | 18-9-4 | 40 PTS | PPG Paints Arena · Pittsburgh, PA |
| 32 | Thu Dec 19 | at Flyers | W7-3 | 19-9-4 | 42 PTS | Wells Fargo Center · Philadelphia, PA |
| 33 | Sat Dec 21 | atPredators | L2-3 (OT) | 19-9-5 | 43 PTS | Bridgestone Arena · Nashville, TN |
| 34 | Sun Dec 22 | at Capitals | L1-3 | 19-10-5 | 43 PTS | Capital One Arena · Washington, D.C. |
| 35 | Sat Dec 28 | vs Oilers | W4-3 (OT) | 20-10-5 | 45 PTS | Crypto.com Arena · Los Angeles, CA |
| 36 | Sun Dec 29 | vsFlyers | W5-4 | 21-10-5 | 47 PTS | Crypto.com Arena · Los Angeles, CA |
| 37 | Wed Jan 1 | vsDevils | W3-0 | 22-10-5 | 49 PTS | Crypto.com Arena · Los Angeles, CA |
| 38 | Sat Jan 4 | vs Lightning | W2-1 | 23-10-5 | 51 PTS | Crypto.com Arena · Los Angeles, CA |
| 39 | Fri Jan 10 | atJets | W2-1 (OT) | 24-10-5 | 53 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 40 | Sat Jan 11 | atFlames | L1-2 | 24-11-5 | 53 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 41 | Mon Jan 13 | atOilers | L0-1 | 24-12-5 | 53 PTS | Rogers Place · Edmonton, AB |
| 42 | Thu Jan 16 | atCanucks | W5-1 | 25-12-5 | 55 PTS | Rogers Arena · Vancouver, British Columbia |
| 43 | Sat Jan 18 | atKraken | L2-4 | 25-13-5 | 55 PTS | Climate Pledge Arena · Seattle, WA |
| 44 | Mon Jan 20 | vsPenguins | L1-5 | 25-14-5 | 55 PTS | Crypto.com Arena · Los Angeles, CA |
| 45 | Wed Jan 22 | vs Panthers | W2-1 | 26-14-5 | 57 PTS | Crypto.com Arena · Los Angeles, CA |
| 46 | Sat Jan 25 | atJackets | L2-3 (OT) | 26-14-6 | 58 PTS | Nationwide Arena · Columbus, OH |
| 47 | Mon Jan 27 | atRed Wings | L2-5 | 26-15-6 | 58 PTS | Little Caesars Arena · Detroit, MI |
| 48 | Wed Jan 29 | atPanthers | L0-3 | 26-16-6 | 58 PTS | Amerant Bank Arena · Sunrise, FL |
| 49 | Thu Jan 30 | atLightning | L0-3 | 26-17-6 | 58 PTS | AMALIE Arena · Tampa, FL |
| 50 | Sat Feb 1 | at Hurricanes | W4-2 | 27-17-6 | 60 PTS | PNC Arena · Raleigh, NC |
| 51 | Wed Feb 5 | vsCanadiens | W6-3 | 28-17-6 | 62 PTS | Crypto.com Arena · Los Angeles, CA |
| 52 | Fri Feb 7 | vsStars | W5-4 (SO) | 29-17-6 | 64 PTS | Crypto.com Arena · Los Angeles, CA |
| 53 | Sat Feb 8 | vsDucks | L1-2 (SO) | 29-17-7 | 65 PTS | Crypto.com Arena · Los Angeles, CA |
Blues