| 1 | Thu Oct 9 | vs Flames | W5-1 | 1-0-0 | 2 PTS | Rogers Arena · Vancouver, British Columbia |
| 2 | Sat Oct 11 | atOilers | L1-3 | 1-1-0 | 2 PTS | Rogers Place · Edmonton, AB |
| 3 | Mon Oct 13 | vsBlues | L2-5 | 1-2-0 | 2 PTS | Rogers Arena · Vancouver, British Columbia |
| 4 | Thu Oct 16 | atStars | W5-3 | 2-2-0 | 4 PTS | American Airlines Center · Dallas, TX |
| 5 | Fri Oct 17 | atBlackhawks | W3-2 (SO) | 3-2-0 | 6 PTS | United Center · Chicago, IL |
| 6 | Sun Oct 19 | atCapitals | W4-3 | 4-2-0 | 8 PTS | Capital One Arena · Washington, D.C. |
| 7 | Tue Oct 21 | atPenguins | L1-5 | 4-3-0 | 8 PTS | PPG Paints Arena · Pittsburgh, PA |
| 8 | Thu Oct 23 | atPredators | L1-2 | 4-4-0 | 8 PTS | Bridgestone Arena · Nashville, TN |
| 9 | Sat Oct 25 | vsCanadiens | L3-4 | 4-5-0 | 8 PTS | Rogers Arena · Vancouver, British Columbia |
| 10 | Sun Oct 26 | vsOilers | W4-3 (OT) | 5-5-0 | 10 PTS | Rogers Arena · Vancouver, British Columbia |
| 11 | Tue Oct 28 | vsRangers | L0-2 | 5-6-0 | 10 PTS | Rogers Arena · Vancouver, British Columbia |
| 12 | Thu Oct 30 | atBlues | W4-3 (SO) | 6-6-0 | 12 PTS | Enterprise Center · St. Louis, MO |
| 13 | Sat Nov 1 | atWild | L2-5 | 6-7-0 | 12 PTS | Xcel Energy Center · St. Paul, MN |
| 14 | Mon Nov 3 | atPredators | W5-4 (OT) | 7-7-0 | 14 PTS | Bridgestone Arena · Nashville, TN |
| 15 | Wed Nov 5 | vsBlackhawks | L2-5 | 7-8-0 | 14 PTS | Rogers Arena · Vancouver, British Columbia |
| 16 | Sat Nov 8 | vsJackets | W4-3 | 8-8-0 | 16 PTS | Rogers Arena · Vancouver, British Columbia |
| 17 | Sun Nov 9 | vsAvalanche | L4-5 (OT) | 8-8-1 | 17 PTS | Rogers Arena · Vancouver, British Columbia |
| 18 | Tue Nov 11 | vsJets | L3-5 | 8-9-1 | 17 PTS | Rogers Arena · Vancouver, British Columbia |
| 19 | Fri Nov 14 | atHurricanes | L3-4 (OT) | 8-9-2 | 18 PTS | PNC Arena · Raleigh, NC |
| 20 | Sun Nov 16 | atLightning | W6-2 | 9-9-2 | 20 PTS | Benchmark International Arena · Tampa, FL |
| 21 | Mon Nov 17 | atPanthers | L5-8 | 9-10-2 | 20 PTS | Amerant Bank Arena · Sunrise, FL |
| 22 | Thu Nov 20 | vsStars | L2-4 | 9-11-2 | 20 PTS | Rogers Arena · Vancouver, British Columbia |
| 23 | Sun Nov 23 | vsFlames | L2-5 | 9-12-2 | 20 PTS | Rogers Arena · Vancouver, British Columbia |
| 24 | Wed Nov 26 | atDucks | W5-4 | 10-12-2 | 22 PTS | Honda Center · Anaheim, CA |
| 25 | Fri Nov 28 | atSharks | L2-3 | 10-13-2 | 22 PTS | SAP Center · San Jose, CA |
| 26 | Sat Nov 29 | atKings | L1-2 (OT) | 10-13-3 | 23 PTS | Crypto.com Arena · Los Angeles, CA |
| 27 | Tue Dec 2 | atAvalanche | L1-3 | 10-14-3 | 23 PTS | Ball Arena · Denver, CO |
| 28 | Fri Dec 5 | vsMammoth | L1-4 | 10-15-3 | 23 PTS | Rogers Arena · Vancouver, British Columbia |
| 29 | Sat Dec 6 | vsWild | W4-2 | 11-15-3 | 25 PTS | Rogers Arena · Vancouver, British Columbia |
| 30 | Mon Dec 8 | vsRed Wings | L0-4 | 11-16-3 | 25 PTS | Rogers Arena · Vancouver, British Columbia |
| 31 | Thu Dec 11 | vsSabres | L2-3 | 11-17-3 | 25 PTS | Rogers Arena · Vancouver, British Columbia |
| 32 | Sun Dec 14 | atDevils | W2-1 | 12-17-3 | 27 PTS | Prudential Center · Newark, NJ |
| 33 | Tue Dec 16 | atRangers | W3-0 | 13-17-3 | 29 PTS | Madison Square Garden · Manhattan, NY |
| 34 | Fri Dec 19 | atIslanders | W4-1 | 14-17-3 | 31 PTS | UBS Arena · Elmont, NY |
| 35 | Sat Dec 20 | atBruins | W5-4 (SO) | 15-17-3 | 33 PTS | TD Garden · Boston, MA |
| 36 | Mon Dec 22 | atFlyers | L2-5 | 15-18-3 | 33 PTS | Wells Fargo Center · Philadelphia, PA |
| 37 | Sat Dec 27 | vsSharks | L3-6 | 15-19-3 | 33 PTS | Rogers Arena · Vancouver, British Columbia |
| 38 | Mon Dec 29 | atKraken | W3-2 (SO) | 16-19-3 | 35 PTS | Climate Pledge Arena · Seattle, WA |
| 39 | Tue Dec 30 | vsFlyers | L3-6 | 16-20-3 | 35 PTS | Rogers Arena · Vancouver, British Columbia |
| 40 | Fri Jan 2 | vsKraken | L3-4 (SO) | 16-20-4 | 36 PTS | Rogers Arena · Vancouver, British Columbia |
| 41 | Sat Jan 3 | vsBruins | L2-3 (OT) | 16-20-5 | 37 PTS | Rogers Arena · Vancouver, British Columbia |
| 42 | Tue Jan 6 | atSabres | L3-5 | 16-21-5 | 37 PTS | KeyBank Center · Buffalo, NY |
| 43 | Thu Jan 8 | atRed Wings | L1-5 | 16-22-5 | 37 PTS | Little Caesars Arena · Detroit, MI |
| 44 | Sat Jan 10 | atMaple Leafs | L0-5 | 16-23-5 | 37 PTS | Scotiabank Arena · Toronto, ON |
| 45 | Mon Jan 12 | atCanadiens | L3-6 | 16-24-5 | 37 PTS | Bell Centre · Montreal, QC |
| 46 | Tue Jan 13 | atSenators | L1-2 | 16-25-5 | 37 PTS | Canadian Tire Centre · Ottawa, ON |
| 47 | Thu Jan 15 | atJackets | L1-4 | 16-26-5 | 37 PTS | Nationwide Arena · Columbus, OH |
| 48 | Sat Jan 17 | vsOilers | L0-6 | 16-27-5 | 37 PTS | Rogers Arena · Vancouver, British Columbia |
| 49 | Mon Jan 19 | vsIslanders | L3-4 | 16-28-5 | 37 PTS | Rogers Arena · Vancouver, British Columbia |
| 50 | Wed Jan 21 | vsCapitals | W4-3 | 17-28-5 | 39 PTS | Rogers Arena · Vancouver, British Columbia |
| 51 | Fri Jan 23 | vsDevils | L4-5 | 17-29-5 | 39 PTS | Rogers Arena · Vancouver, British Columbia |
| 52 | Sun Jan 25 | vsPenguins | L2-3 | 17-30-5 | 39 PTS | Rogers Arena · Vancouver, British Columbia |
| 53 | Tue Jan 27 | vsSharks | L2-5 | 17-31-5 | 39 PTS | Rogers Arena · Vancouver, British Columbia |
| 54 | Thu Jan 29 | vsDucks | W2-0 | 18-31-5 | 41 PTS | Rogers Arena · Vancouver, British Columbia |
| 55 | Sat Jan 31 | vsMaple Leafs | L2-3 (SO) | 18-31-6 | 42 PTS | Rogers Arena · Vancouver, British Columbia |
| 56 | Mon Feb 2 | atMammoth | L2-6 | 18-32-6 | 42 PTS | Delta Center · Salt Lake City, UT |
| 57 | Wed Feb 4 | atKnights | L2-5 | 18-33-6 | 42 PTS | T-Mobile Arena · Las Vegas, NV |
| 58 | Wed Feb 25 | vsJets | L2-3 (OT) | 18-33-7 | 43 PTS | Rogers Arena · Vancouver, British Columbia |
| 59 | Sat Feb 28 | atKraken | L1-5 | 18-34-7 | 43 PTS | Climate Pledge Arena · Seattle, WA |
