| 1 | Wed Oct 9 | vs Flames | L5-6 (OT) | 0-0-1 | 1 PTS | Rogers Arena · Vancouver, British Columbia |
| 2 | Fri Oct 11 | vs Flyers | L2-3 (SO) | 0-0-2 | 2 PTS | Rogers Arena · Vancouver, British Columbia |
| 3 | Tue Oct 15 | at Lightning | L1-4 | 0-1-2 | 2 PTS | AMALIE Arena · Tampa, FL |
| 4 | Thu Oct 17 | at Panthers | W3-2 (OT) | 1-1-2 | 4 PTS | Amerant Bank Arena · Sunrise, FL |
| 5 | Sat Oct 19 | atFlyers | W3-0 | 2-1-2 | 6 PTS | Wells Fargo Center · Philadelphia, PA |
| 6 | Tue Oct 22 | at Blackhawks | W6-3 | 3-1-2 | 8 PTS | United Center · Chicago, IL |
| 7 | Sat Oct 26 | vs Penguins | W4-3 | 4-1-2 | 10 PTS | Rogers Arena · Vancouver, British Columbia |
| 8 | Mon Oct 28 | vs Hurricanes | L3-4 (OT) | 4-1-3 | 11 PTS | Rogers Arena · Vancouver, British Columbia |
| 9 | Wed Oct 30 | vs Devils | L0-6 | 4-2-3 | 11 PTS | Rogers Arena · Vancouver, British Columbia |
| 10 | Sat Nov 2 | at Sharks | W3-2 | 5-2-3 | 13 PTS | SAP Center · San Jose, CA |
| 11 | Tue Nov 5 | at Ducks | W5-1 | 6-2-3 | 15 PTS | Honda Center · Anaheim, CA |
| 12 | Thu Nov 7 | at Kings | W4-2 | 7-2-3 | 17 PTS | Crypto.com Arena · Los Angeles, CA |
| 13 | Sat Nov 9 | vs Oilers | L3-7 | 7-3-3 | 17 PTS | Rogers Arena · Vancouver, British Columbia |
| 14 | Tue Nov 12 | vsFlames | W3-1 | 8-3-3 | 19 PTS | Rogers Arena · Vancouver, British Columbia |
| 15 | Thu Nov 14 | vs Islanders | L2-5 | 8-4-3 | 19 PTS | Rogers Arena · Vancouver, British Columbia |
| 16 | Sat Nov 16 | vsBlackhawks | W4-1 | 9-4-3 | 21 PTS | Rogers Arena · Vancouver, British Columbia |
| 17 | Sun Nov 17 | vs Predators | L3-5 | 9-5-3 | 21 PTS | Rogers Arena · Vancouver, British Columbia |
| 18 | Tue Nov 19 | vs Rangers | L3-4 | 9-6-3 | 21 PTS | Rogers Arena · Vancouver, British Columbia |
| 19 | Sat Nov 23 | at Senators | W4-3 | 10-6-3 | 23 PTS | Canadian Tire Centre · Ottawa, ON |
| 20 | Tue Nov 26 | at Bruins | W2-0 | 11-6-3 | 25 PTS | TD Garden · Boston, MA |
| 21 | Wed Nov 27 | atPenguins | L4-5 | 11-7-3 | 25 PTS | PPG Paints Arena · Pittsburgh, PA |
| 22 | Fri Nov 29 | at Sabres | W4-3 (OT) | 12-7-3 | 27 PTS | KeyBank Center · Buffalo, NY |
| 23 | Sun Dec 1 | at Red Wings | W5-4 (OT) | 13-7-3 | 29 PTS | Little Caesars Arena · Detroit, MI |
| 24 | Tue Dec 3 | at Wild | L2-3 (OT) | 13-7-4 | 30 PTS | Xcel Energy Center · St. Paul, MN |
| 25 | Fri Dec 6 | vs Jackets | W5-2 | 14-7-4 | 32 PTS | Rogers Arena · Vancouver, British Columbia |
| 26 | Sun Dec 8 | vsLightning | L2-4 | 14-8-4 | 32 PTS | Rogers Arena · Vancouver, British Columbia |
| 27 | Tue Dec 10 | vs Blues | L3-4 (OT) | 14-8-5 | 33 PTS | Rogers Arena · Vancouver, British Columbia |
| 28 | Thu Dec 12 | vsPanthers | W4-0 | 15-8-5 | 35 PTS | Rogers Arena · Vancouver, British Columbia |
| 29 | Sat Dec 14 | vsBruins | L1-5 | 15-9-5 | 35 PTS | Rogers Arena · Vancouver, British Columbia |
| 30 | Mon Dec 16 | vs Avalanche | W3-1 | 16-9-5 | 37 PTS | Rogers Arena · Vancouver, British Columbia |
| 31 | Wed Dec 18 | at Utah HC | L2-3 (OT) | 16-9-6 | 38 PTS | Delta Center · Salt Lake City, UT |
| 32 | Thu Dec 19 | at Knights | L1-3 | 16-10-6 | 38 PTS | T-Mobile Arena · Las Vegas, NV |
| 33 | Sat Dec 21 | vsSenators | L4-5 (OT) | 16-10-7 | 39 PTS | Rogers Arena · Vancouver, British Columbia |
| 34 | Mon Dec 23 | vsSharks | W4-3 | 17-10-7 | 41 PTS | Rogers Arena · Vancouver, British Columbia |
| 35 | Sat Dec 28 | vs Kraken | L4-5 (OT) | 17-10-8 | 42 PTS | Rogers Arena · Vancouver, British Columbia |
| 36 | Tue Dec 31 | atFlames | L1-3 | 17-11-8 | 42 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 37 | Thu Jan 2 | atKraken | W4-3 (SO) | 18-11-8 | 44 PTS | Climate Pledge Arena · Seattle, WA |
| 38 | Fri Jan 3 | vsPredators | L0-3 | 18-12-8 | 44 PTS | Rogers Arena · Vancouver, British Columbia |
| 39 | Mon Jan 6 | at Canadiens | L4-5 (OT) | 18-12-9 | 45 PTS | Bell Centre · Montreal, QC |
| 40 | Wed Jan 8 | at Capitals | L1-2 (OT) | 18-12-10 | 46 PTS | Capital One Arena · Washington, D.C. |
| 41 | Fri Jan 10 | atHurricanes | L0-2 | 18-13-10 | 46 PTS | PNC Arena · Raleigh, NC |
| 42 | Sat Jan 11 | at Maple Leafs | W3-0 | 19-13-10 | 48 PTS | Scotiabank Arena · Toronto, ON |
| 43 | Tue Jan 14 | at Jets | L1-6 | 19-14-10 | 48 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 44 | Thu Jan 16 | vsKings | L1-5 | 19-15-10 | 48 PTS | Rogers Arena · Vancouver, British Columbia |
| 45 | Sat Jan 18 | vsOilers | W3-2 | 20-15-10 | 50 PTS | Rogers Arena · Vancouver, British Columbia |
| 46 | Tue Jan 21 | vsSabres | L2-3 | 20-16-10 | 50 PTS | Rogers Arena · Vancouver, British Columbia |
| 47 | Thu Jan 23 | atOilers | L2-6 | 20-17-10 | 50 PTS | Rogers Place · Edmonton, AB |
| 48 | Sat Jan 25 | vsCapitals | W2-1 | 21-17-10 | 52 PTS | Rogers Arena · Vancouver, British Columbia |
| 49 | Mon Jan 27 | atBlues | W5-2 | 22-17-10 | 54 PTS | Enterprise Center · St. Louis, MO |
| 50 | Wed Jan 29 | atPredators | W3-1 | 23-17-10 | 56 PTS | Bridgestone Arena · Nashville, TN |
| 51 | Fri Jan 31 | at Stars | L3-5 | 23-18-10 | 56 PTS | American Airlines Center · Dallas, TX |
| 52 | Sun Feb 2 | vsRed Wings | L2-3 (OT) | 23-18-11 | 57 PTS | Rogers Arena · Vancouver, British Columbia |
| 53 | Tue Feb 4 | vsAvalanche | W3-0 | 24-18-11 | 59 PTS | Rogers Arena · Vancouver, British Columbia |
| 54 | Thu Feb 6 | atSharks | W2-1 (OT) | 25-18-11 | 61 PTS | SAP Center · San Jose, CA |
| 55 | Sat Feb 8 | vsMaple Leafs | W2-1 | 26-18-11 | 63 PTS | Rogers Arena · Vancouver, British Columbia |
