| 27 | Thu Dec 4 | vs Red Wings | 7:30 PM | 14-11-2 | 30 PTS | Nationwide Arena · Columbus, OH |
| 28 | Sat Dec 6 | at Panthers | 3:30 PM | 12-12-1 | 25 PTS | Amerant Bank Arena · Sunrise, FL |
| 29 | Sun Dec 7 | at Capitals | 7:00 PM | 17-9-2 | 36 PTS | Capital One Arena · Washington, D.C. |
| 30 | Tue Dec 9 | at Hurricanes | 7:30 PM | 16-7-2 | 34 PTS | PNC Arena · Raleigh, NC |
| 31 | Thu Dec 11 | vs Senators | 7:00 PM | 13-9-4 | 30 PTS | Nationwide Arena · Columbus, OH |
| 32 | Sat Dec 13 | vs Knights | 7:00 PM | 12-6-8 | 32 PTS | Nationwide Arena · Columbus, OH |
| 33 | Tue Dec 16 | vs Ducks | 7:00 PM | 16-10-1 | 33 PTS | Nationwide Arena · Columbus, OH |
| 34 | Thu Dec 18 | vs Wild | 7:00 PM | 15-7-5 | 35 PTS | Nationwide Arena · Columbus, OH |
| 35 | Sat Dec 20 | at Ducks | 10:00 PM | 16-10-1 | 33 PTS | Honda Center · Anaheim, CA |
| 36 | Mon Dec 22 | at Kings | 10:00 PM | 12-7-7 | 31 PTS | Crypto.com Arena · Los Angeles, CA |
| 37 | Sun Dec 28 | vs Islanders | 5:00 PM | 14-10-3 | 31 PTS | Nationwide Arena · Columbus, OH |
| 38 | Mon Dec 29 | at Senators | 7:00 PM | 13-9-4 | 30 PTS | Canadian Tire Centre · Ottawa, ON |
| 39 | Wed Dec 31 | vs Devils | 7:00 PM | 16-10-1 | 33 PTS | Nationwide Arena · Columbus, OH |
| 40 | Sat Jan 3 | vs Sabres | 3:00 PM | 11-12-4 | 26 PTS | Nationwide Arena · Columbus, OH |
| 41 | Sun Jan 4 | vs Penguins | 3:00 PM | 13-7-5 | 31 PTS | Nationwide Arena · Columbus, OH |
| 42 | Tue Jan 6 | at Sharks | 10:00 PM | 13-12-3 | 29 PTS | SAP Center · San Jose, CA |
| 43 | Thu Jan 8 | at Knights | 10:00 PM | 12-6-8 | 32 PTS | T-Mobile Arena · Las Vegas, NV |
| 44 | Sat Jan 10 | at Avalanche | 4:00 PM | 19-1-6 | 44 PTS | Ball Arena · Denver, CO |
| 45 | Sun Jan 11 | at Mammoth | 7:00 PM | 13-12-3 | 29 PTS | Delta Center · Salt Lake City, UT |
| 46 | Tue Jan 13 | vs Flames | 7:00 PM | 9-15-4 | 22 PTS | Nationwide Arena · Columbus, OH |
| 47 | Thu Jan 15 | vs Canucks | 7:00 PM | 10-14-3 | 23 PTS | Nationwide Arena · Columbus, OH |
| 48 | Sat Jan 17 | at Penguins | 7:00 PM | 13-7-5 | 31 PTS | PPG Paints Arena · Pittsburgh, PA |
| 49 | Tue Jan 20 | vs Senators | 7:00 PM | 13-9-4 | 30 PTS | Nationwide Arena · Columbus, OH |
| 50 | Thu Jan 22 | vs Stars | 7:00 PM | 18-5-5 | 41 PTS | Nationwide Arena · Columbus, OH |
| 51 | Sat Jan 24 | vs Lightning | 7:00 PM | 16-8-2 | 34 PTS | Nationwide Arena · Columbus, OH |
| 52 | Mon Jan 26 | vs Kings | 7:00 PM | 12-7-7 | 31 PTS | Nationwide Arena · Columbus, OH |
| 53 | Wed Jan 28 | vs Flyers | 7:00 PM | 15-8-3 | 33 PTS | Nationwide Arena · Columbus, OH |
| 54 | Fri Jan 30 | at Blackhawks | 8:30 PM | 11-9-6 | 28 PTS | United Center · Chicago, IL |
| 55 | Sat Jan 31 | at Blues | 7:00 PM | 9-11-7 | 25 PTS | Enterprise Center · St. Louis, MO |
| 56 | Tue Feb 3 | at Devils | 7:00 PM | 16-10-1 | 33 PTS | Prudential Center · Newark, NJ |
| 57 | Wed Feb 4 | vs Blackhawks | 7:00 PM | 11-9-6 | 28 PTS | Nationwide Arena · Columbus, OH |
| 58 | Thu Feb 26 | at Bruins | 7:00 PM | 15-13-0 | 30 PTS | TD Garden · Boston, MA |
| 59 | Sat Feb 28 | vs Islanders | 6:00 PM | 14-10-3 | 31 PTS | Nationwide Arena · Columbus, OH |
| 60 | Mon Mar 2 | at Rangers | 7:00 PM | 14-12-2 | 30 PTS | Madison Square Garden · Manhattan, NY |
| 61 | Tue Mar 3 | vs Predators | 7:00 PM | 9-13-4 | 22 PTS | Nationwide Arena · Columbus, OH |
| 62 | Thu Mar 5 | vs Panthers | 7:00 PM | 12-12-1 | 25 PTS | Nationwide Arena · Columbus, OH |
| 63 | Sat Mar 7 | vs Mammoth | 7:00 PM | 13-12-3 | 29 PTS | Nationwide Arena · Columbus, OH |
| 64 | Tue Mar 10 | at Lightning | 7:00 PM | 16-8-2 | 34 PTS | AMALIE Arena · Tampa, FL |
| 65 | Thu Mar 12 | at Panthers | 7:00 PM | 12-12-1 | 25 PTS | Amerant Bank Arena · Sunrise, FL |
| 66 | Sat Mar 14 | at Flyers | 7:30 PM | 15-8-3 | 33 PTS | Wells Fargo Center · Philadelphia, PA |
| 67 | Tue Mar 17 | vs Hurricanes | 7:00 PM | 16-7-2 | 34 PTS | Nationwide Arena · Columbus, OH |
| 68 | Thu Mar 19 | vs Rangers | 7:00 PM | 14-12-2 | 30 PTS | Nationwide Arena · Columbus, OH |
| 69 | Sat Mar 21 | vs Kraken | 5:00 PM | 11-7-6 | 28 PTS | Nationwide Arena · Columbus, OH |
| 70 | Sun Mar 22 | at Islanders | 7:00 PM | 14-10-3 | 31 PTS | UBS Arena · Elmont, NY |
| 71 | Tue Mar 24 | at Flyers | 7:00 PM | 15-8-3 | 33 PTS | Wells Fargo Center · Philadelphia, PA |
| 72 | Thu Mar 26 | at Canadiens | 7:00 PM | 14-9-3 | 31 PTS | Bell Centre · Montreal, QC |
| 73 | Sat Mar 28 | vs Sharks | 5:00 PM | 13-12-3 | 29 PTS | Nationwide Arena · Columbus, OH |
| 74 | Sun Mar 29 | vs Bruins | 5:00 PM | 15-13-0 | 30 PTS | Nationwide Arena · Columbus, OH |
| 75 | Tue Mar 31 | vs Hurricanes | 7:30 PM | 16-7-2 | 34 PTS | Nationwide Arena · Columbus, OH |
| 76 | Thu Apr 2 | at Hurricanes | 7:00 PM | 16-7-2 | 34 PTS | PNC Arena · Raleigh, NC |
| 77 | Sat Apr 4 | vs Jets | 7:00 PM | 13-12-1 | 27 PTS | Nationwide Arena · Columbus, OH |
| 78 | Tue Apr 7 | at Red Wings | 7:00 PM | 14-11-2 | 30 PTS | Little Caesars Arena · Detroit, MI |
| 79 | Thu Apr 9 | at Sabres | 7:00 PM | 11-12-4 | 26 PTS | KeyBank Center · Buffalo, NY |
| 80 | Sat Apr 11 | at Canadiens | 7:00 PM | 14-9-3 | 31 PTS | Bell Centre · Montreal, QC |
| 81 | Sun Apr 12 | vs Bruins | 6:00 PM | 15-13-0 | 30 PTS | Nationwide Arena · Columbus, OH |
| 82 | Tue Apr 14 | vs Capitals | 7:00 PM | 17-9-2 | 36 PTS | Nationwide Arena · Columbus, OH |