| 1 | Thu Oct 9 | at Predators | L1-2 | 0-1-0 | 0 PTS | Bridgestone Arena · Nashville, TN |
| 2 | Sat Oct 11 | atWild | W7-4 | 1-1-0 | 2 PTS | Xcel Energy Center · St. Paul, MN |
| 3 | Mon Oct 13 | vsDevils | L2-3 | 1-2-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 4 | Thu Oct 16 | vsAvalanche | L1-4 | 1-3-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 5 | Sat Oct 18 | vsLightning | W3-2 | 2-3-0 | 4 PTS | Nationwide Arena · Columbus, OH |
| 6 | Tue Oct 21 | atStars | W5-1 | 3-3-0 | 6 PTS | American Airlines Center · Dallas, TX |
| 7 | Fri Oct 24 | vsCapitals | L1-5 | 3-4-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 8 | Sat Oct 25 | atPenguins | W5-4 (SO) | 4-4-0 | 8 PTS | PPG Paints Arena · Pittsburgh, PA |
| 9 | Tue Oct 28 | atSabres | W4-3 (OT) | 5-4-0 | 10 PTS | KeyBank Center · Buffalo, NY |
| 10 | Wed Oct 29 | vsMaple Leafs | W6-3 | 6-4-0 | 12 PTS | Nationwide Arena · Columbus, OH |
| 11 | Sat Nov 1 | vsBlues | W3-2 | 7-4-0 | 14 PTS | Nationwide Arena · Columbus, OH |
| 12 | Sun Nov 2 | atIslanders | L2-3 | 7-5-0 | 14 PTS | UBS Arena · Elmont, NY |
| 13 | Wed Nov 5 | atFlames | L1-5 | 7-6-0 | 14 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 14 | Sat Nov 8 | atCanucks | L3-4 | 7-7-0 | 14 PTS | Rogers Arena · Vancouver, British Columbia |
| 15 | Mon Nov 10 | atOilers | L4-5 (OT) | 7-7-1 | 15 PTS | Rogers Place · Edmonton, AB |
| 16 | Tue Nov 11 | atKraken | W2-1 (SO) | 8-7-1 | 17 PTS | Climate Pledge Arena · Seattle, WA |
| 17 | Thu Nov 13 | vsOilers | W5-4 | 9-7-1 | 19 PTS | Nationwide Arena · Columbus, OH |
| 18 | Sat Nov 15 | vsRangers | L1-2 (SO) | 9-7-2 | 20 PTS | Nationwide Arena · Columbus, OH |
| 19 | Mon Nov 17 | vsCanadiens | W4-3 (SO) | 10-7-2 | 22 PTS | Nationwide Arena · Columbus, OH |
| 20 | Tue Nov 18 | atJets | L2-5 | 10-8-2 | 22 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 21 | Thu Nov 20 | atMaple Leafs | W3-2 (OT) | 11-8-2 | 24 PTS | Scotiabank Arena · Toronto, ON |
| 22 | Sat Nov 22 | atRed Wings | L3-4 (OT) | 11-8-3 | 25 PTS | Little Caesars Arena · Detroit, MI |
| 23 | Mon Nov 24 | atCapitals | L1-5 | 11-9-3 | 25 PTS | Capital One Arena · Washington, D.C. |
| 24 | Wed Nov 26 | vsMaple Leafs | L1-2 (OT) | 11-9-4 | 26 PTS | Nationwide Arena · Columbus, OH |
| 25 | Fri Nov 28 | vsPenguins | L3-4 (OT) | 11-9-5 | 27 PTS | Nationwide Arena · Columbus, OH |
| 26 | Mon Dec 1 | atDevils | W5-3 | 12-9-5 | 29 PTS | Prudential Center · Newark, NJ |
| 27 | Thu Dec 4 | vsRed Wings | W6-5 (SO) | 13-9-5 | 31 PTS | Nationwide Arena · Columbus, OH |
| 28 | Sat Dec 6 | atPanthers | L6-7 (OT) | 13-9-6 | 32 PTS | Amerant Bank Arena · Sunrise, FL |
| 29 | Sun Dec 7 | atCapitals | L0-2 | 13-10-6 | 32 PTS | Capital One Arena · Washington, D.C. |
| 30 | Tue Dec 9 | atHurricanes | L1-4 | 13-11-6 | 32 PTS | PNC Arena · Raleigh, NC |
| 31 | Thu Dec 11 | vsSenators | L3-6 | 13-12-6 | 32 PTS | Nationwide Arena · Columbus, OH |
| 32 | Sat Dec 13 | vsKnights | L2-3 | 13-13-6 | 32 PTS | Nationwide Arena · Columbus, OH |
| 33 | Tue Dec 16 | vsDucks | W4-3 (OT) | 14-13-6 | 34 PTS | Nationwide Arena · Columbus, OH |
| 34 | Thu Dec 18 | vsWild | L2-5 | 14-14-6 | 34 PTS | Nationwide Arena · Columbus, OH |
| 35 | Sat Dec 20 | atDucks | L3-4 | 14-15-6 | 34 PTS | Honda Center · Anaheim, CA |
| 36 | Mon Dec 22 | atKings | W3-1 | 15-15-6 | 36 PTS | Crypto.com Arena · Los Angeles, CA |
| 37 | Sun Dec 28 | vsIslanders | W4-2 | 16-15-6 | 38 PTS | Nationwide Arena · Columbus, OH |
| 38 | Mon Dec 29 | atSenators | W4-1 | 17-15-6 | 40 PTS | Canadian Tire Centre · Ottawa, ON |
| 39 | Wed Dec 31 | vsDevils | L2-3 | 17-16-6 | 40 PTS | Nationwide Arena · Columbus, OH |
| 40 | Sat Jan 3 | vsSabres | W5-1 | 18-16-6 | 42 PTS | Nationwide Arena · Columbus, OH |
| 41 | Sun Jan 4 | vsPenguins | L4-5 (OT) | 18-16-7 | 43 PTS | Nationwide Arena · Columbus, OH |
| 42 | Tue Jan 6 | atSharks | L2-5 | 18-17-7 | 43 PTS | SAP Center · San Jose, CA |
| 43 | Thu Jan 8 | atKnights | L3-5 | 18-18-7 | 43 PTS | T-Mobile Arena · Las Vegas, NV |
| 44 | Sat Jan 10 | atAvalanche | L0-4 | 18-19-7 | 43 PTS | Ball Arena · Denver, CO |
| 45 | Sun Jan 11 | atMammoth | W3-2 (OT) | 19-19-7 | 45 PTS | Delta Center · Salt Lake City, UT |
| 46 | Tue Jan 13 | vsFlames | W5-3 | 20-19-7 | 47 PTS | Nationwide Arena · Columbus, OH |
| 47 | Thu Jan 15 | vsCanucks | W4-1 | 21-19-7 | 49 PTS | Nationwide Arena · Columbus, OH |
| 48 | Sat Jan 17 | atPenguins | W4-3 (SO) | 22-19-7 | 51 PTS | PPG Paints Arena · Pittsburgh, PA |
| 49 | Tue Jan 20 | vsSenators | L1-4 | 22-20-7 | 51 PTS | Nationwide Arena · Columbus, OH |
| 50 | Thu Jan 22 | vsStars | W1-0 | 23-20-7 | 53 PTS | Nationwide Arena · Columbus, OH |
| 51 | Sat Jan 24 | vsLightning | W8-5 | 24-20-7 | 55 PTS | Nationwide Arena · Columbus, OH |
| 52 | Wed Jan 28 | vsFlyers | W5-3 | 25-20-7 | 57 PTS | Nationwide Arena · Columbus, OH |
| 53 | Fri Jan 30 | atBlackhawks | W4-2 | 26-20-7 | 59 PTS | United Center · Chicago, IL |
| 54 | Sat Jan 31 | atBlues | W5-3 | 27-20-7 | 61 PTS | Enterprise Center · St. Louis, MO |
| 55 | Tue Feb 3 | atDevils | W3-0 | 28-20-7 | 63 PTS | Prudential Center · Newark, NJ |
| 56 | Wed Feb 4 | vsBlackhawks | W4-0 | 29-20-7 | 65 PTS | Nationwide Arena · Columbus, OH |
| 57 | Thu Feb 26 | atBruins | L2-4 | 29-21-7 | 65 PTS | TD Garden · Boston, MA |
| 58 | Sat Feb 28 | vsIslanders | L3-4 (OT) | 29-21-8 | 66 PTS | Nationwide Arena · Columbus, OH |
