| 1 | Thu Oct 10 | at Wild | L2-3 | 0-1-0 | 0 PTS | Xcel Energy Center · St. Paul, MN |
| 2 | Sat Oct 12 | atAvalanche | W6-4 | 1-1-0 | 2 PTS | Ball Arena · Denver, CO |
| 3 | Tue Oct 15 | vsPanthers | L3-4 | 1-2-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 4 | Thu Oct 17 | vsSabres | W6-4 | 2-2-0 | 4 PTS | Nationwide Arena · Columbus, OH |
| 5 | Sat Oct 19 | vsWild | L1-3 | 2-3-0 | 4 PTS | Nationwide Arena · Columbus, OH |
| 6 | Tue Oct 22 | vsMaple Leafs | W6-2 | 3-3-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 7 | Sat Oct 26 | atPredators | L3-4 (OT) | 3-3-1 | 7 PTS | Bridgestone Arena · Nashville, TN |
| 8 | Mon Oct 28 | vsOilers | W6-1 | 4-3-1 | 9 PTS | Nationwide Arena · Columbus, OH |
| 9 | Wed Oct 30 | vsIslanders | W2-0 | 5-3-1 | 11 PTS | Nationwide Arena · Columbus, OH |
| 10 | Fri Nov 1 | vsJets | L2-6 | 5-4-1 | 11 PTS | Nationwide Arena · Columbus, OH |
| 11 | Sat Nov 2 | atCapitals | L2-7 | 5-5-1 | 11 PTS | Capital One Arena · Washington, D.C. |
| 12 | Tue Nov 5 | atSharks | L1-2 (OT) | 5-5-2 | 12 PTS | SAP Center · San Jose, CA |
| 13 | Sat Nov 9 | atKings | L2-5 | 5-6-2 | 12 PTS | Crypto.com Arena · Los Angeles, CA |
| 14 | Sun Nov 10 | atDucks | L2-4 | 5-7-2 | 12 PTS | Honda Center · Anaheim, CA |
| 15 | Tue Nov 12 | atKraken | L2-5 | 5-8-2 | 12 PTS | Climate Pledge Arena · Seattle, WA |
| 16 | Fri Nov 15 | vsPenguins | W6-2 | 6-8-2 | 14 PTS | Nationwide Arena · Columbus, OH |
| 17 | Sat Nov 16 | atCanadiens | L1-5 | 6-9-2 | 14 PTS | Bell Centre · Montreal, QC |
| 18 | Mon Nov 18 | atBruins | W5-1 | 7-9-2 | 16 PTS | TD Garden · Boston, MA |
| 19 | Thu Nov 21 | vsLightning | W7-6 (OT) | 8-9-2 | 18 PTS | Nationwide Arena · Columbus, OH |
| 20 | Sat Nov 23 | vsHurricanes | W5-4 (SO) | 9-9-2 | 20 PTS | Nationwide Arena · Columbus, OH |
| 21 | Wed Nov 27 | vsCanadiens | L3-4 (OT) | 9-9-3 | 21 PTS | Nationwide Arena · Columbus, OH |
| 22 | Fri Nov 29 | vsFlames | W5-2 | 10-9-3 | 23 PTS | Nationwide Arena · Columbus, OH |
| 23 | Sun Dec 1 | atBlackhawks | W6-3 | 11-9-3 | 25 PTS | United Center · Chicago, IL |
| 24 | Tue Dec 3 | atFlames | L0-3 | 11-10-3 | 25 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 25 | Thu Dec 5 | atOilers | L3-6 | 11-11-3 | 25 PTS | Rogers Place · Edmonton, AB |
| 26 | Fri Dec 6 | atCanucks | L2-5 | 11-12-3 | 25 PTS | Rogers Arena · Vancouver, British Columbia |
| 27 | Sun Dec 8 | atJets | W4-1 | 12-12-3 | 27 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 28 | Tue Dec 10 | vsFlyers | L3-5 | 12-13-3 | 27 PTS | Nationwide Arena · Columbus, OH |
| 29 | Thu Dec 12 | vsCapitals | L1-2 (OT) | 12-13-4 | 28 PTS | Nationwide Arena · Columbus, OH |
| 30 | Sat Dec 14 | vsDucks | L3-4 (OT) | 12-13-5 | 29 PTS | Nationwide Arena · Columbus, OH |
| 31 | Sun Dec 15 | atHurricanes | L1-4 | 12-14-5 | 29 PTS | PNC Arena · Raleigh, NC |
| 32 | Tue Dec 17 | atLightning | L3-5 | 12-15-5 | 29 PTS | AMALIE Arena · Tampa, FL |
| 33 | Thu Dec 19 | vsDevils | W4-2 | 13-15-5 | 31 PTS | Nationwide Arena · Columbus, OH |
| 34 | Sat Dec 21 | atFlyers | L4-5 (OT) | 13-15-6 | 32 PTS | Wells Fargo Center · Philadelphia, PA |
| 35 | Mon Dec 23 | vsCanadiens | W5-4 | 14-15-6 | 34 PTS | Nationwide Arena · Columbus, OH |
| 36 | Fri Dec 27 | vsBruins | W6-2 | 15-15-6 | 36 PTS | Nationwide Arena · Columbus, OH |
| 37 | Sat Dec 28 | atBruins | L0-4 | 15-16-6 | 36 PTS | TD Garden · Boston, MA |
| 38 | Tue Dec 31 | vsHurricanes | W4-3 (SO) | 16-16-6 | 38 PTS | Nationwide Arena · Columbus, OH |
| 39 | Thu Jan 2 | vsRed Wings | L4-5 | 16-17-6 | 38 PTS | Nationwide Arena · Columbus, OH |
| 40 | Sat Jan 4 | vsBlues | W6-4 | 17-17-6 | 40 PTS | Nationwide Arena · Columbus, OH |
| 41 | Tue Jan 7 | atPenguins | W4-3 (SO) | 18-17-6 | 42 PTS | PPG Paints Arena · Pittsburgh, PA |
| 42 | Thu Jan 9 | vsKraken | W6-2 | 19-17-6 | 44 PTS | Nationwide Arena · Columbus, OH |
| 43 | Sat Jan 11 | atBlues | W2-1 | 20-17-6 | 46 PTS | Enterprise Center · St. Louis, MO |
| 44 | Tue Jan 14 | vsFlyers | W3-2 (SO) | 21-17-6 | 48 PTS | Nationwide Arena · Columbus, OH |
| 45 | Thu Jan 16 | vsSharks | W4-1 | 22-17-6 | 50 PTS | Nationwide Arena · Columbus, OH |
| 46 | Sat Jan 18 | atRangers | L0-1 (SO) | 22-17-7 | 51 PTS | Madison Square Garden · Manhattan, NY |
| 47 | Mon Jan 20 | atIslanders | L1-3 | 22-18-7 | 51 PTS | UBS Arena · Elmont, NY |
| 48 | Wed Jan 22 | atMaple Leafs | W5-1 | 23-18-7 | 53 PTS | Scotiabank Arena · Toronto, ON |
| 49 | Thu Jan 23 | atHurricanes | L4-7 | 23-19-7 | 53 PTS | PNC Arena · Raleigh, NC |
| 50 | Sat Jan 25 | vsKings | W3-2 (OT) | 24-19-7 | 55 PTS | Nationwide Arena · Columbus, OH |
| 51 | Thu Jan 30 | atKnights | W2-1 (OT) | 25-19-7 | 57 PTS | T-Mobile Arena · Las Vegas, NV |
| 52 | Fri Jan 31 | atUtah HC | W3-2 (OT) | 26-19-7 | 59 PTS | Delta Center · Salt Lake City, UT |
| 53 | Sun Feb 2 | atStars | L3-5 | 26-20-7 | 59 PTS | American Airlines Center · Dallas, TX |
| 54 | Tue Feb 4 | atSabres | L2-3 | 26-21-7 | 59 PTS | KeyBank Center · Buffalo, NY |
| 55 | Thu Feb 6 | vsUtah HC | L2-3 (OT) | 26-21-8 | 60 PTS | Nationwide Arena · Columbus, OH |
| 56 | Sat Feb 8 | vsRangers | L3-4 | 26-22-8 | 60 PTS | Nationwide Arena · Columbus, OH |
| 57 | Sat Feb 22 | vsBlackhawks | W5-1 | 27-22-8 | 62 PTS | Nationwide Arena · Columbus, OH |
| 58 | Tue Feb 25 | vsStars | W6-4 | 28-22-8 | 64 PTS | Nationwide Arena · Columbus, OH |
| 59 | Thu Feb 27 | atRed Wings | W5-2 | 29-22-8 | 66 PTS | Little Caesars Arena · Detroit, MI |
| 60 | Sat Mar 1 | vsRed Wings | W5-3 | 30-22-8 | 68 PTS | Nationwide Arena · Columbus, OH |
| 61 | Tue Mar 4 | atLightning | L2-6 | 30-23-8 | 68 PTS | AMALIE Arena · Tampa, FL |
| 62 | Thu Mar 6 | atPanthers | L0-3 | 30-24-8 | 68 PTS | Amerant Bank Arena · Sunrise, FL |
| 63 | Sun Mar 9 | atRangers | W7-3 | 31-24-8 | 70 PTS | Madison Square Garden · Manhattan, NY |
| 64 | Tue Mar 11 | atDevils | L3-5 | 31-25-8 | 70 PTS | Prudential Center · Newark, NJ |
| 65 | Thu Mar 13 | vsKnights | L0-4 | 31-26-8 | 70 PTS | Nationwide Arena · Columbus, OH |
| 66 | Sat Mar 15 | vsRangers | L0-4 | 31-27-8 | 70 PTS | Nationwide Arena · Columbus, OH |
| 67 | Mon Mar 17 | vsDevils | L1-2 | 31-28-8 | 70 PTS | Nationwide Arena · Columbus, OH |
| 68 | Thu Mar 20 | vsPanthers | L0-1 (OT) | 31-28-9 | 71 PTS | Nationwide Arena · Columbus, OH |
| 69 | Fri Mar 21 | atPenguins | L3-6 | 31-29-9 | 71 PTS | PPG Paints Arena · Pittsburgh, PA |
| 70 | Mon Mar 24 | atIslanders | W4-3 (SO) | 32-29-9 | 73 PTS | UBS Arena · Elmont, NY |
| 71 | Fri Mar 28 | vsCanucks | W7-6 (SO) | 33-29-9 | 75 PTS | Nationwide Arena · Columbus, OH |
| 72 | Sat Mar 29 | atSenators | L2-3 | 33-30-9 | 75 PTS | Canadian Tire Centre · Ottawa, ON |
| 73 | Tue Apr 1 | vsPredators | W8-4 | 34-30-9 | 77 PTS | Nationwide Arena · Columbus, OH |
| 74 | Thu Apr 3 | vsAvalanche | L3-7 | 34-31-9 | 77 PTS | Nationwide Arena · Columbus, OH |
| 75 | Sat Apr 5 | atMaple Leafs | L0-5 | 34-32-9 | 77 PTS | Scotiabank Arena · Toronto, ON |
| 76 | Sun Apr 6 | atSenators | L0-4 | 34-33-9 | 77 PTS | Canadian Tire Centre · Ottawa, ON |
| 77 | Tue Apr 8 | vsSenators | W5-2 | 35-33-9 | 79 PTS | Nationwide Arena · Columbus, OH |
| 78 | Thu Apr 10 | vsSabres | W3-2 | 36-33-9 | 81 PTS | Nationwide Arena · Columbus, OH |
| 79 | Sat Apr 12 | vsCapitals | W7-0 | 37-33-9 | 83 PTS | Nationwide Arena · Columbus, OH |
| 80 | Sun Apr 13 | atCapitals | W4-1 | 38-33-9 | 85 PTS | Capital One Arena · Washington, D.C. |
| 81 | Tue Apr 15 | atFlyers | W3-0 | 39-33-9 | 87 PTS | Wells Fargo Center · Philadelphia, PA |
| 82 | Thu Apr 17 | vsIslanders | W6-1 | 40-33-9 | 89 PTS | Nationwide Arena · Columbus, OH |
