| 1 | Wed Oct 12 | at Hurricanes | L1-4 | 0-1-0 | 0 PTS | PNC Arena · Raleigh, NC |
| 2 | Fri Oct 14 | vsLightning | L2-5 | 0-2-0 | 0 PTS | Nationwide Arena · Columbus, OH |
| 3 | Sat Oct 15 | atBlues | L2-5 | 0-3-0 | 0 PTS | Enterprise Center · St. Louis, MO |
| 4 | Tue Oct 18 | vsCanucks | W4-3 (OT) | 1-3-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 5 | Thu Oct 20 | vsPredators | W5-3 | 2-3-0 | 4 PTS | Nationwide Arena · Columbus, OH |
| 6 | Sat Oct 22 | vsPenguins | L3-6 | 2-4-0 | 4 PTS | Nationwide Arena · Columbus, OH |
| 7 | Sun Oct 23 | atRangers | W5-1 | 3-4-0 | 6 PTS | Madison Square Garden · Manhattan, NY |
| 8 | Tue Oct 25 | vsCoyotes | L3-6 | 3-5-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 9 | Fri Oct 28 | vsBruins | L0-4 | 3-6-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 10 | Sun Oct 30 | atDevils | L1-7 | 3-7-0 | 6 PTS | Prudential Center · Newark, NJ |
| 11 | Fri Nov 4 | atAvalanche | L3-6 | 3-8-0 | 6 PTS | Ball Arena · Denver, CO |
| 12 | Sat Nov 5 | vsAvalanche | L1-5 | 3-9-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 13 | Thu Nov 10 | vsFlyers | W5-2 | 4-9-0 | 8 PTS | Nationwide Arena · Columbus, OH |
| 14 | Sat Nov 12 | atIslanders | L3-4 (OT) | 4-9-1 | 9 PTS | UBS Arena · Elmont, NY |
| 15 | Tue Nov 15 | vsFlyers | W5-4 (OT) | 5-9-1 | 11 PTS | Nationwide Arena · Columbus, OH |
| 16 | Thu Nov 17 | vsCanadiens | W6-4 | 6-9-1 | 13 PTS | Nationwide Arena · Columbus, OH |
| 17 | Sat Nov 19 | vsRed Wings | L1-6 | 6-10-1 | 13 PTS | Nationwide Arena · Columbus, OH |
| 18 | Sun Nov 20 | vsPanthers | W5-3 | 7-10-1 | 15 PTS | Nationwide Arena · Columbus, OH |
| 19 | Wed Nov 23 | vsCanadiens | L1-3 | 7-11-1 | 15 PTS | Nationwide Arena · Columbus, OH |
| 20 | Fri Nov 25 | vsIslanders | L2-3 | 7-12-1 | 15 PTS | Nationwide Arena · Columbus, OH |
| 21 | Mon Nov 28 | vsKnights | L2-3 (SO) | 7-12-2 | 16 PTS | Nationwide Arena · Columbus, OH |
| 22 | Fri Dec 2 | atJets | W4-1 | 8-12-2 | 18 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 23 | Sun Dec 4 | vsRed Wings | L2-4 | 8-13-2 | 18 PTS | Nationwide Arena · Columbus, OH |
| 24 | Tue Dec 6 | atPenguins | L1-4 | 8-14-2 | 18 PTS | PPG Paints Arena · Pittsburgh, PA |
| 25 | Wed Dec 7 | vsSabres | L4-9 | 8-15-2 | 18 PTS | Nationwide Arena · Columbus, OH |
| 26 | Fri Dec 9 | vsFlames | W3-1 | 9-15-2 | 20 PTS | Nationwide Arena · Columbus, OH |
| 27 | Sun Dec 11 | vsKings | W6-5 (OT) | 10-15-2 | 22 PTS | Nationwide Arena · Columbus, OH |
| 28 | Tue Dec 13 | atPanthers | L0-4 | 10-16-2 | 22 PTS | Amerant Bank Arena · Sunrise, FL |
| 29 | Thu Dec 15 | atLightning | L1-4 | 10-17-2 | 22 PTS | AMALIE Arena · Tampa, FL |
| 30 | Sat Dec 17 | atBruins | L2-4 | 10-18-2 | 22 PTS | TD Garden · Boston, MA |
| 31 | Mon Dec 19 | vsStars | L1-2 | 10-19-2 | 22 PTS | Nationwide Arena · Columbus, OH |
| 32 | Tue Dec 20 | atFlyers | L3-5 | 10-20-2 | 22 PTS | Wells Fargo Center · Philadelphia, PA |
| 33 | Fri Dec 23 | atBlackhawks | L2-5 | 10-21-2 | 22 PTS | United Center · Chicago, IL |
| 34 | Thu Dec 29 | atIslanders | L1-2 | 10-22-2 | 22 PTS | UBS Arena · Elmont, NY |
| 35 | Sat Dec 31 | vsBlackhawks | W4-1 | 11-22-2 | 24 PTS | Nationwide Arena · Columbus, OH |
| 36 | Tue Jan 3 | atSenators | L0-4 | 11-23-2 | 24 PTS | Canadian Tire Centre · Ottawa, ON |
| 37 | Thu Jan 5 | vsCapitals | L2-6 | 11-24-2 | 24 PTS | Nationwide Arena · Columbus, OH |
| 38 | Sat Jan 7 | vsHurricanes | W4-3 (SO) | 12-24-2 | 26 PTS | Nationwide Arena · Columbus, OH |
| 39 | Sun Jan 8 | atCapitals | L0-1 | 12-25-2 | 26 PTS | Capital One Arena · Washington, D.C. |
| 40 | Tue Jan 10 | atLightning | L3-6 | 12-26-2 | 26 PTS | AMALIE Arena · Tampa, FL |
| 41 | Thu Jan 12 | vsHurricanes | L2-6 | 12-27-2 | 26 PTS | Nationwide Arena · Columbus, OH |
| 42 | Sat Jan 14 | atRed Wings | W4-3 | 13-27-2 | 28 PTS | Little Caesars Arena · Detroit, MI |
| 43 | Mon Jan 16 | vsRangers | L1-3 | 13-28-2 | 28 PTS | Nationwide Arena · Columbus, OH |
| 44 | Tue Jan 17 | atPredators | L1-2 | 13-29-2 | 28 PTS | Bridgestone Arena · Nashville, TN |
| 45 | Thu Jan 19 | vsDucks | L3-5 | 13-30-2 | 28 PTS | Nationwide Arena · Columbus, OH |
| 46 | Sat Jan 21 | vsSharks | W5-3 | 14-30-2 | 30 PTS | Nationwide Arena · Columbus, OH |
| 47 | Mon Jan 23 | atFlames | L3-4 (OT) | 14-30-3 | 31 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 48 | Wed Jan 25 | atOilers | W3-2 (OT) | 15-30-3 | 33 PTS | Rogers Place · Edmonton, AB |
| 49 | Fri Jan 27 | atCanucks | L2-5 | 15-31-3 | 33 PTS | Rogers Arena · Vancouver, British Columbia |
| 50 | Sat Jan 28 | atKraken | L1-3 | 15-32-3 | 33 PTS | Climate Pledge Arena · Seattle, WA |
| 51 | Tue Jan 31 | vsCapitals | L3-4 (OT) | 15-32-4 | 34 PTS | Nationwide Arena · Columbus, OH |
| 52 | Fri Feb 10 | vsMaple Leafs | L0-3 | 15-33-4 | 34 PTS | Nationwide Arena · Columbus, OH |
| 53 | Sat Feb 11 | atMaple Leafs | W4-3 | 16-33-4 | 36 PTS | Scotiabank Arena · Toronto, ON |
| 54 | Tue Feb 14 | vsDevils | L2-3 | 16-34-4 | 36 PTS | Nationwide Arena · Columbus, OH |
| 55 | Thu Feb 16 | vsJets | W3-1 | 17-34-4 | 38 PTS | Nationwide Arena · Columbus, OH |
| 56 | Sat Feb 18 | atStars | W4-1 | 18-34-4 | 40 PTS | American Airlines Center · Dallas, TX |
| 57 | Sun Feb 19 | atCoyotes | L2-3 (OT) | 18-34-5 | 41 PTS | Mullett Arena · Tempe, AZ |
| 58 | Thu Feb 23 | vsWild | L0-2 | 18-35-5 | 41 PTS | Nationwide Arena · Columbus, OH |
| 59 | Sat Feb 25 | vsOilers | W6-5 | 19-35-5 | 43 PTS | Nationwide Arena · Columbus, OH |
| 60 | Sun Feb 26 | atWild | L2-3 (OT) | 19-35-6 | 44 PTS | Xcel Energy Center · St. Paul, MN |
| 61 | Tue Feb 28 | atSabres | W5-3 | 20-35-6 | 46 PTS | KeyBank Center · Buffalo, NY |
| 62 | Fri Mar 3 | vsKraken | L2-4 | 20-36-6 | 46 PTS | Nationwide Arena · Columbus, OH |
| 63 | Sat Mar 4 | atSenators | L2-5 | 20-37-6 | 46 PTS | Canadian Tire Centre · Ottawa, ON |
| 64 | Tue Mar 7 | atPenguins | L4-5 (OT) | 20-37-7 | 47 PTS | PPG Paints Arena · Pittsburgh, PA |
| 65 | Sat Mar 11 | vsBlues | L2-5 | 20-38-7 | 47 PTS | Nationwide Arena · Columbus, OH |
| 66 | Tue Mar 14 | atSharks | W6-5 (OT) | 21-38-7 | 49 PTS | SAP Center · San Jose, CA |
| 67 | Thu Mar 16 | atKings | L1-4 | 21-39-7 | 49 PTS | Crypto.com Arena · Los Angeles, CA |
| 68 | Fri Mar 17 | atDucks | L4-7 | 21-40-7 | 49 PTS | Honda Center · Anaheim, CA |
| 69 | Sun Mar 19 | atKnights | L2-7 | 21-41-7 | 49 PTS | T-Mobile Arena · Las Vegas, NV |
| 70 | Tue Mar 21 | atCapitals | W7-6 (OT) | 22-41-7 | 51 PTS | Capital One Arena · Washington, D.C. |
| 71 | Fri Mar 24 | vsIslanders | W5-4 (OT) | 23-41-7 | 53 PTS | Nationwide Arena · Columbus, OH |
| 72 | Sat Mar 25 | atCanadiens | L2-8 | 23-42-7 | 53 PTS | Bell Centre · Montreal, QC |
| 73 | Tue Mar 28 | atRangers | L2-6 | 23-43-7 | 53 PTS | Madison Square Garden · Manhattan, NY |
| 74 | Thu Mar 30 | atBruins | L1-2 (OT) | 23-43-8 | 54 PTS | TD Garden · Boston, MA |
| 75 | Sat Apr 1 | vsPanthers | L0-7 | 23-44-8 | 54 PTS | Nationwide Arena · Columbus, OH |
| 76 | Sun Apr 2 | vsSenators | W4-3 (OT) | 24-44-8 | 56 PTS | Nationwide Arena · Columbus, OH |
| 77 | Tue Apr 4 | atMaple Leafs | L2-4 | 24-45-8 | 56 PTS | Scotiabank Arena · Toronto, ON |
| 78 | Thu Apr 6 | atDevils | L1-8 | 24-46-8 | 56 PTS | Prudential Center · Newark, NJ |
| 79 | Sat Apr 8 | vsRangers | L0-4 | 24-47-8 | 56 PTS | Nationwide Arena · Columbus, OH |
| 80 | Tue Apr 11 | atFlyers | L3-4 (OT) | 24-47-9 | 57 PTS | Wells Fargo Center · Philadelphia, PA |
| 81 | Thu Apr 13 | vsPenguins | W3-2 (OT) | 25-47-9 | 59 PTS | Nationwide Arena · Columbus, OH |
| 82 | Fri Apr 14 | vsSabres | L2-5 | 25-48-9 | 59 PTS | Nationwide Arena · Columbus, OH |
