| 1 | Thu Jan 14 | at Predators | L1-3 | 0-1-0 | 0 PTS | Bridgestone Arena · Nashville, TN |
| 2 | Sat Jan 16 | at Predators | L2-5 | 0-2-0 | 0 PTS | Bridgestone Arena · Nashville, TN |
| 3 | Mon Jan 18 | at Red Wings | W3-2 | 1-2-0 | 2 PTS | Little Caesars Arena · Detroit, MI |
| 4 | Tue Jan 19 | at Red Wings | L2-3 (OT) | 1-2-1 | 3 PTS | Little Caesars Arena · Detroit, MI |
| 5 | Thu Jan 21 | vs Lightning | L2-3 (OT) | 1-2-2 | 4 PTS | Nationwide Arena · Columbus, OH |
| 6 | Sat Jan 23 | vs Lightning | W5-2 | 2-2-2 | 6 PTS | Nationwide Arena · Columbus, OH |
| 7 | Tue Jan 26 | vs Panthers | L3-4 (SO) | 2-2-3 | 7 PTS | Nationwide Arena · Columbus, OH |
| 8 | Thu Jan 28 | vs Panthers | W3-2 (SO) | 3-2-3 | 9 PTS | Nationwide Arena · Columbus, OH |
| 9 | Fri Jan 29 | at Blackhawks | W2-1 | 4-2-3 | 11 PTS | United Center · Chicago, IL |
| 10 | Sun Jan 31 | at Blackhawks | L1-3 | 4-3-3 | 11 PTS | United Center · Chicago, IL |
| 11 | Tue Feb 2 | vs Stars | L3-6 | 4-4-3 | 11 PTS | Nationwide Arena · Columbus, OH |
| 12 | Thu Feb 4 | vs Stars | W4-3 | 5-4-3 | 13 PTS | Nationwide Arena · Columbus, OH |
| 13 | Sun Feb 7 | vs Hurricanes | L5-6 | 5-5-3 | 13 PTS | Nationwide Arena · Columbus, OH |
| 14 | Mon Feb 8 | vs Hurricanes | W3-2 | 6-5-3 | 15 PTS | Nationwide Arena · Columbus, OH |
| 15 | Thu Feb 11 | at Blackhawks | W6-5 | 7-5-3 | 17 PTS | United Center · Chicago, IL |
| 16 | Sat Feb 13 | at Blackhawks | L2-3 (OT) | 7-5-4 | 18 PTS | United Center · Chicago, IL |
| 17 | Mon Feb 15 | at Hurricanes | L3-7 | 7-6-4 | 18 PTS | PNC Arena · Raleigh, NC |
| 18 | Thu Feb 18 | vs Predators | W3-0 | 8-6-4 | 20 PTS | Nationwide Arena · Columbus, OH |
| 19 | Sat Feb 20 | vs Predators | L2-4 | 8-7-4 | 20 PTS | Nationwide Arena · Columbus, OH |
| 20 | Tue Feb 23 | vs Blackhawks | L5-6 (SO) | 8-7-5 | 21 PTS | Nationwide Arena · Columbus, OH |
| 21 | Thu Feb 25 | vs Blackhawks | L0-2 | 8-8-5 | 21 PTS | Nationwide Arena · Columbus, OH |
| 22 | Sat Feb 27 | at Predators | L1-2 | 8-9-5 | 21 PTS | Bridgestone Arena · Nashville, TN |
| 23 | Sun Feb 28 | at Predators | L1-3 | 8-10-5 | 21 PTS | Bridgestone Arena · Nashville, TN |
| 24 | Tue Mar 2 | vs Red Wings | W4-1 | 9-10-5 | 23 PTS | Nationwide Arena · Columbus, OH |
| 25 | Thu Mar 4 | at Stars | W3-2 | 10-10-5 | 25 PTS | American Airlines Center · Dallas, TX |
| 26 | Sat Mar 6 | at Stars | L0-5 | 10-11-5 | 25 PTS | American Airlines Center · Dallas, TX |
| 27 | Tue Mar 9 | vs Panthers | L2-4 | 10-12-5 | 25 PTS | Nationwide Arena · Columbus, OH |
| 28 | Thu Mar 11 | vs Panthers | L4-5 (OT) | 10-12-6 | 26 PTS | Nationwide Arena · Columbus, OH |
| 29 | Sat Mar 13 | vs Stars | W4-3 (OT) | 11-12-6 | 28 PTS | Nationwide Arena · Columbus, OH |
| 30 | Sun Mar 14 | vs Stars | L1-2 (SO) | 11-12-7 | 29 PTS | Nationwide Arena · Columbus, OH |
| 31 | Thu Mar 18 | at Hurricanes | W3-2 (OT) | 12-12-7 | 31 PTS | PNC Arena · Raleigh, NC |
| 32 | Sat Mar 20 | at Hurricanes | W3-2 (SO) | 13-12-7 | 33 PTS | PNC Arena · Raleigh, NC |
| 33 | Mon Mar 22 | vs Hurricanes | L0-3 | 13-13-7 | 33 PTS | Nationwide Arena · Columbus, OH |
| 34 | Thu Mar 25 | vs Hurricanes | L3-4 (OT) | 13-13-8 | 34 PTS | Nationwide Arena · Columbus, OH |
| 35 | Sat Mar 27 | at Red Wings | L1-3 | 13-14-8 | 34 PTS | Little Caesars Arena · Detroit, MI |
| 36 | Sun Mar 28 | at Red Wings | L1-4 | 13-15-8 | 34 PTS | Little Caesars Arena · Detroit, MI |
| 37 | Tue Mar 30 | at Lightning | W3-1 | 14-15-8 | 36 PTS | AMALIE Arena · Tampa, FL |
| 38 | Thu Apr 1 | at Lightning | L2-3 | 14-16-8 | 36 PTS | AMALIE Arena · Tampa, FL |
| 39 | Sat Apr 3 | at Panthers | L2-5 | 14-17-8 | 36 PTS | Amerant Bank Arena · Sunrise, FL |
| 40 | Sun Apr 4 | at Panthers | L0-3 | 14-18-8 | 36 PTS | Amerant Bank Arena · Sunrise, FL |
| 41 | Tue Apr 6 | vs Lightning | W4-2 | 15-18-8 | 38 PTS | Nationwide Arena · Columbus, OH |
| 42 | Thu Apr 8 | vs Lightning | L4-6 | 15-19-8 | 38 PTS | Nationwide Arena · Columbus, OH |
| 43 | Sat Apr 10 | vs Blackhawks | L3-4 | 15-20-8 | 38 PTS | Nationwide Arena · Columbus, OH |
| 44 | Mon Apr 12 | vs Blackhawks | L3-4 (OT) | 15-20-9 | 39 PTS | Nationwide Arena · Columbus, OH |
| 45 | Thu Apr 15 | at Stars | L1-4 | 15-21-9 | 39 PTS | American Airlines Center · Dallas, TX |
| 46 | Sat Apr 17 | at Stars | L1-5 | 15-22-9 | 39 PTS | American Airlines Center · Dallas, TX |
| 47 | Mon Apr 19 | at Panthers | L2-4 | 15-23-9 | 39 PTS | Amerant Bank Arena · Sunrise, FL |
| 48 | Tue Apr 20 | at Panthers | L1-5 | 15-24-9 | 39 PTS | Amerant Bank Arena · Sunrise, FL |
| 49 | Thu Apr 22 | at Lightning | L1-3 | 15-25-9 | 39 PTS | AMALIE Arena · Tampa, FL |
| 50 | Sun Apr 25 | at Lightning | L3-4 (OT) | 15-25-10 | 40 PTS | AMALIE Arena · Tampa, FL |
| 51 | Tue Apr 27 | vs Red Wings | W1-0 (SO) | 16-25-10 | 42 PTS | Nationwide Arena · Columbus, OH |
| 52 | Sat May 1 | at Hurricanes | L1-2 (OT) | 16-25-11 | 43 PTS | PNC Arena · Raleigh, NC |
| 53 | Mon May 3 | vs Predators | L3-4 (OT) | 16-25-12 | 44 PTS | Nationwide Arena · Columbus, OH |
| 54 | Wed May 5 | vs Predators | W4-2 | 17-25-12 | 46 PTS | Nationwide Arena · Columbus, OH |
| 55 | Fri May 7 | vs Red Wings | L2-5 | 17-26-12 | 46 PTS | Nationwide Arena · Columbus, OH |
| 56 | Sat May 8 | vs Red Wings | W5-4 (OT) | 18-26-12 | 48 PTS | Nationwide Arena · Columbus, OH |