| 1 | Thu Oct 12 | vs Flyers | L2-4 | 0-1-0 | 0 PTS | Nationwide Arena · Columbus, OH |
| 2 | Sat Oct 14 | vsRangers | W5-3 | 1-1-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 3 | Mon Oct 16 | vsRed Wings | L0-4 | 1-2-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 4 | Fri Oct 20 | vsFlames | W3-1 | 2-2-0 | 4 PTS | Nationwide Arena · Columbus, OH |
| 5 | Sat Oct 21 | atWild | W5-4 (OT) | 3-2-0 | 6 PTS | Xcel Energy Center · St. Paul, MN |
| 6 | Tue Oct 24 | vsDucks | L2-3 (OT) | 3-2-1 | 7 PTS | Nationwide Arena · Columbus, OH |
| 7 | Thu Oct 26 | atCanadiens | L3-4 (OT) | 3-2-2 | 8 PTS | Bell Centre · Montreal, QC |
| 8 | Sat Oct 28 | vsIslanders | L0-2 | 3-3-2 | 8 PTS | Nationwide Arena · Columbus, OH |
| 9 | Mon Oct 30 | atStars | L3-5 | 3-4-2 | 8 PTS | American Airlines Center · Dallas, TX |
| 10 | Thu Nov 2 | vsLightning | W4-2 | 4-4-2 | 10 PTS | Nationwide Arena · Columbus, OH |
| 11 | Sat Nov 4 | atCapitals | L1-2 | 4-5-2 | 10 PTS | Capital One Arena · Washington, D.C. |
| 12 | Mon Nov 6 | atPanthers | L4-5 (OT) | 4-5-3 | 11 PTS | Amerant Bank Arena · Sunrise, FL |
| 13 | Thu Nov 9 | vsStars | L2-5 | 4-6-3 | 11 PTS | Nationwide Arena · Columbus, OH |
| 14 | Sat Nov 11 | atRed Wings | L4-5 | 4-7-3 | 11 PTS | Little Caesars Arena · Detroit, MI |
| 15 | Sun Nov 12 | atRangers | L3-4 (SO) | 4-7-4 | 12 PTS | Madison Square Garden · Manhattan, NY |
| 16 | Tue Nov 14 | vsPenguins | L3-5 | 4-8-4 | 12 PTS | Nationwide Arena · Columbus, OH |
| 17 | Thu Nov 16 | vsCoyotes | L2-3 | 4-9-4 | 12 PTS | Nationwide Arena · Columbus, OH |
| 18 | Sat Nov 18 | atCapitals | L3-4 | 4-10-4 | 12 PTS | Capital One Arena · Washington, D.C. |
| 19 | Sun Nov 19 | atFlyers | L2-5 | 4-11-4 | 12 PTS | Wells Fargo Center · Philadelphia, PA |
| 20 | Wed Nov 22 | vsBlackhawks | W7-3 | 5-11-4 | 14 PTS | Nationwide Arena · Columbus, OH |
| 21 | Fri Nov 24 | atDevils | W2-1 | 6-11-4 | 16 PTS | Prudential Center · Newark, NJ |
| 22 | Sun Nov 26 | atHurricanes | L2-3 | 6-12-4 | 16 PTS | PNC Arena · Raleigh, NC |
| 23 | Mon Nov 27 | vsBruins | W5-2 | 7-12-4 | 18 PTS | Nationwide Arena · Columbus, OH |
| 24 | Wed Nov 29 | vsCanadiens | L2-4 | 7-13-4 | 18 PTS | Nationwide Arena · Columbus, OH |
| 25 | Fri Dec 1 | vsSenators | W4-2 | 8-13-4 | 20 PTS | Nationwide Arena · Columbus, OH |
| 26 | Sun Dec 3 | atBruins | L1-3 | 8-14-4 | 20 PTS | TD Garden · Boston, MA |
| 27 | Tue Dec 5 | vsKings | L3-4 (OT) | 8-14-5 | 21 PTS | Nationwide Arena · Columbus, OH |
| 28 | Thu Dec 7 | atIslanders | L3-7 | 8-15-5 | 21 PTS | UBS Arena · Elmont, NY |
| 29 | Fri Dec 8 | vsBlues | W5-2 | 9-15-5 | 23 PTS | Nationwide Arena · Columbus, OH |
| 30 | Sun Dec 10 | vsPanthers | L2-5 | 9-16-5 | 23 PTS | Nationwide Arena · Columbus, OH |
| 31 | Thu Dec 14 | atMaple Leafs | W6-5 (OT) | 10-16-5 | 25 PTS | Scotiabank Arena · Toronto, ON |
| 32 | Sat Dec 16 | vsDevils | L3-6 | 10-17-5 | 25 PTS | Nationwide Arena · Columbus, OH |
| 33 | Tue Dec 19 | atSabres | W9-4 | 11-17-5 | 27 PTS | KeyBank Center · Buffalo, NY |
| 34 | Thu Dec 21 | vsCapitals | L2-3 (OT) | 11-17-6 | 28 PTS | Nationwide Arena · Columbus, OH |
| 35 | Sat Dec 23 | vsMaple Leafs | L1-4 | 11-18-6 | 28 PTS | Nationwide Arena · Columbus, OH |
| 36 | Wed Dec 27 | atDevils | L3-4 (OT) | 11-18-7 | 29 PTS | Prudential Center · Newark, NJ |
| 37 | Fri Dec 29 | vsMaple Leafs | W6-5 (OT) | 12-18-7 | 31 PTS | Nationwide Arena · Columbus, OH |
| 38 | Sat Dec 30 | atSabres | L2-3 (OT) | 12-18-8 | 32 PTS | KeyBank Center · Buffalo, NY |
| 39 | Tue Jan 2 | vsBruins | L1-4 | 12-19-8 | 32 PTS | Nationwide Arena · Columbus, OH |
| 40 | Thu Jan 4 | atFlyers | W3-2 (SO) | 13-19-8 | 34 PTS | Wells Fargo Center · Philadelphia, PA |
| 41 | Sat Jan 6 | vsWild | L3-4 (OT) | 13-19-9 | 35 PTS | Nationwide Arena · Columbus, OH |
| 42 | Tue Jan 9 | atJets | L0-5 | 13-20-9 | 35 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 43 | Sat Jan 13 | vsKraken | L4-7 | 13-21-9 | 35 PTS | Nationwide Arena · Columbus, OH |
| 44 | Mon Jan 15 | vsCanucks | W4-3 (SO) | 14-21-9 | 37 PTS | Nationwide Arena · Columbus, OH |
| 45 | Fri Jan 19 | vsDevils | L1-4 | 14-22-9 | 37 PTS | Nationwide Arena · Columbus, OH |
| 46 | Tue Jan 23 | atOilers | L1-4 | 14-23-9 | 37 PTS | Rogers Place · Edmonton, AB |
| 47 | Thu Jan 25 | atFlames | W5-2 | 15-23-9 | 39 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 48 | Sat Jan 27 | atCanucks | L4-5 (OT) | 15-23-10 | 40 PTS | Rogers Arena · Vancouver, British Columbia |
| 49 | Sun Jan 28 | atKraken | L2-4 | 15-24-10 | 40 PTS | Climate Pledge Arena · Seattle, WA |
| 50 | Tue Jan 30 | atBlues | W1-0 | 16-24-10 | 42 PTS | Enterprise Center · St. Louis, MO |
| 51 | Sat Feb 10 | vsLightning | L2-4 | 16-25-10 | 42 PTS | Nationwide Arena · Columbus, OH |
| 52 | Tue Feb 13 | atSenators | L3-6 | 16-26-10 | 42 PTS | Canadian Tire Centre · Ottawa, ON |
| 53 | Sat Feb 17 | atSharks | W4-3 | 17-26-10 | 44 PTS | SAP Center · San Jose, CA |
| 54 | Tue Feb 20 | atKings | L1-5 | 17-27-10 | 44 PTS | Crypto.com Arena · Los Angeles, CA |
| 55 | Wed Feb 21 | atDucks | W7-4 | 18-27-10 | 46 PTS | Honda Center · Anaheim, CA |
| 56 | Fri Feb 23 | vsSabres | L1-2 | 18-28-10 | 46 PTS | Nationwide Arena · Columbus, OH |
| 57 | Sun Feb 25 | vsRangers | W4-2 | 19-28-10 | 48 PTS | Nationwide Arena · Columbus, OH |
| 58 | Wed Feb 28 | atRangers | L1-4 | 19-29-10 | 48 PTS | Madison Square Garden · Manhattan, NY |
| 59 | Thu Feb 29 | vsHurricanes | L2-4 | 19-30-10 | 48 PTS | Nationwide Arena · Columbus, OH |
| 60 | Sat Mar 2 | atBlackhawks | W5-2 | 20-30-10 | 50 PTS | United Center · Chicago, IL |
| 61 | Mon Mar 4 | vsKnights | W6-3 | 21-30-10 | 52 PTS | Nationwide Arena · Columbus, OH |
| 62 | Tue Mar 5 | atPenguins | L3-5 | 21-31-10 | 52 PTS | PPG Paints Arena · Pittsburgh, PA |
| 63 | Thu Mar 7 | vsOilers | W4-2 | 22-31-10 | 54 PTS | Nationwide Arena · Columbus, OH |
| 64 | Sat Mar 9 | vsPredators | L1-2 | 22-32-10 | 54 PTS | Nationwide Arena · Columbus, OH |
| 65 | Tue Mar 12 | atCanadiens | L0-3 | 22-33-10 | 54 PTS | Bell Centre · Montreal, QC |
| 66 | Thu Mar 14 | vsSenators | L2-3 (SO) | 22-33-11 | 55 PTS | Nationwide Arena · Columbus, OH |
| 67 | Sat Mar 16 | vsSharks | W4-2 | 23-33-11 | 57 PTS | Nationwide Arena · Columbus, OH |
| 68 | Sun Mar 17 | vsJets | L1-6 | 23-34-11 | 57 PTS | Nationwide Arena · Columbus, OH |
| 69 | Tue Mar 19 | atRed Wings | L3-4 (OT) | 23-34-12 | 58 PTS | Little Caesars Arena · Detroit, MI |
| 70 | Fri Mar 22 | atAvalanche | L1-6 | 23-35-12 | 58 PTS | Ball Arena · Denver, CO |
| 71 | Sat Mar 23 | atKnights | L2-4 | 23-36-12 | 58 PTS | T-Mobile Arena · Las Vegas, NV |
| 72 | Tue Mar 26 | atCoyotes | L2-6 | 23-37-12 | 58 PTS | Mullett Arena · Tempe, AZ |
| 73 | Thu Mar 28 | atPenguins | L2-3 | 23-38-12 | 58 PTS | PPG Paints Arena · Pittsburgh, PA |
| 74 | Sat Mar 30 | vsPenguins | W4-3 (SO) | 24-38-12 | 60 PTS | Nationwide Arena · Columbus, OH |
| 75 | Mon Apr 1 | vsAvalanche | W4-1 | 25-38-12 | 62 PTS | Nationwide Arena · Columbus, OH |
| 76 | Thu Apr 4 | vsIslanders | L2-4 | 25-39-12 | 62 PTS | Nationwide Arena · Columbus, OH |
| 77 | Sat Apr 6 | vsFlyers | W6-2 | 26-39-12 | 64 PTS | Nationwide Arena · Columbus, OH |
| 78 | Sun Apr 7 | atHurricanes | L0-3 | 26-40-12 | 64 PTS | PNC Arena · Raleigh, NC |
| 79 | Tue Apr 9 | atLightning | L2-5 | 26-41-12 | 64 PTS | AMALIE Arena · Tampa, FL |
| 80 | Thu Apr 11 | atPanthers | L0-4 | 26-42-12 | 64 PTS | Amerant Bank Arena · Sunrise, FL |
| 81 | Sat Apr 13 | atPredators | L4-6 | 26-43-12 | 64 PTS | Bridgestone Arena · Nashville, TN |
| 82 | Tue Apr 16 | vsHurricanes | W6-3 | 27-43-12 | 66 PTS | Nationwide Arena · Columbus, OH |
