| 1 | Thu Oct 14 | vs Coyotes | W8-2 | 1-0-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 2 | Sat Oct 16 | vsKraken | W2-1 (OT) | 2-0-0 | 4 PTS | Nationwide Arena · Columbus, OH |
| 3 | Tue Oct 19 | atRed Wings | L1-4 | 2-1-0 | 4 PTS | Little Caesars Arena · Detroit, MI |
| 4 | Thu Oct 21 | vsIslanders | W3-2 (OT) | 3-1-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 5 | Sat Oct 23 | vsHurricanes | L1-5 | 3-2-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 6 | Mon Oct 25 | vsStars | W4-1 | 4-2-0 | 8 PTS | Nationwide Arena · Columbus, OH |
| 7 | Fri Oct 29 | atRangers | L0-4 | 4-3-0 | 8 PTS | Madison Square Garden · Manhattan, NY |
| 8 | Sun Oct 31 | atDevils | W4-3 (SO) | 5-3-0 | 10 PTS | Prudential Center · Newark, NJ |
| 9 | Wed Nov 3 | atAvalanche | W5-4 (OT) | 6-3-0 | 12 PTS | Ball Arena · Denver, CO |
| 10 | Sat Nov 6 | vsAvalanche | W4-2 | 7-3-0 | 14 PTS | Nationwide Arena · Columbus, OH |
| 11 | Fri Nov 12 | vsCapitals | L3-4 | 7-4-0 | 14 PTS | Nationwide Arena · Columbus, OH |
| 12 | Sat Nov 13 | vsRangers | L3-5 | 7-5-0 | 14 PTS | Nationwide Arena · Columbus, OH |
| 13 | Mon Nov 15 | vsRed Wings | W5-3 | 8-5-0 | 16 PTS | Nationwide Arena · Columbus, OH |
| 14 | Thu Nov 18 | atCoyotes | W5-4 (SO) | 9-5-0 | 18 PTS | Mullett Arena · Tempe, AZ |
| 15 | Sat Nov 20 | atKnights | L2-3 | 9-6-0 | 18 PTS | T-Mobile Arena · Las Vegas, NV |
| 16 | Mon Nov 22 | atSabres | W7-4 | 10-6-0 | 20 PTS | KeyBank Center · Buffalo, NY |
| 17 | Wed Nov 24 | vsJets | W3-0 | 11-6-0 | 22 PTS | Nationwide Arena · Columbus, OH |
| 18 | Fri Nov 26 | vsCanucks | W4-2 | 12-6-0 | 24 PTS | Nationwide Arena · Columbus, OH |
| 19 | Sat Nov 27 | atBlues | L3-6 | 12-7-0 | 24 PTS | Enterprise Center · St. Louis, MO |
| 20 | Tue Nov 30 | atPredators | L0-6 | 12-8-0 | 24 PTS | Bridgestone Arena · Nashville, TN |
| 21 | Thu Dec 2 | atStars | L2-3 | 12-9-0 | 24 PTS | American Airlines Center · Dallas, TX |
| 22 | Sat Dec 4 | atCapitals | L1-3 | 12-10-0 | 24 PTS | Capital One Arena · Washington, D.C. |
| 23 | Sun Dec 5 | vsSharks | W6-4 | 13-10-0 | 26 PTS | Nationwide Arena · Columbus, OH |
| 24 | Tue Dec 7 | atMaple Leafs | L4-5 | 13-11-0 | 26 PTS | Scotiabank Arena · Toronto, ON |
| 25 | Thu Dec 9 | vsDucks | L1-2 (SO) | 13-11-1 | 27 PTS | Nationwide Arena · Columbus, OH |
| 26 | Sat Dec 11 | atKraken | W5-4 (OT) | 14-11-1 | 29 PTS | Climate Pledge Arena · Seattle, WA |
| 27 | Tue Dec 14 | atCanucks | L3-4 | 14-12-1 | 29 PTS | Rogers Arena · Vancouver, British Columbia |
| 28 | Thu Dec 16 | atOilers | L2-5 | 14-13-1 | 29 PTS | Rogers Place · Edmonton, AB |
| 29 | Thu Dec 30 | vsPredators | W4-3 (SO) | 15-13-1 | 31 PTS | Nationwide Arena · Columbus, OH |
| 30 | Sat Jan 1 | vsHurricanes | L4-7 | 15-14-1 | 31 PTS | Nationwide Arena · Columbus, OH |
| 31 | Tue Jan 4 | vsLightning | L2-7 | 15-15-1 | 31 PTS | Nationwide Arena · Columbus, OH |
| 32 | Thu Jan 6 | atDevils | L1-3 | 15-16-1 | 31 PTS | Prudential Center · Newark, NJ |
| 33 | Sat Jan 8 | vsDevils | W4-3 | 16-16-1 | 33 PTS | Nationwide Arena · Columbus, OH |
| 34 | Tue Jan 11 | vsBlackhawks | L2-4 | 16-17-1 | 33 PTS | Nationwide Arena · Columbus, OH |
| 35 | Thu Jan 13 | atHurricanes | W6-0 | 17-17-1 | 35 PTS | PNC Arena · Raleigh, NC |
| 36 | Sat Jan 15 | atPanthers | L2-9 | 17-18-1 | 35 PTS | Amerant Bank Arena · Sunrise, FL |
| 37 | Thu Jan 20 | atFlyers | W2-1 | 18-18-1 | 37 PTS | Wells Fargo Center · Philadelphia, PA |
| 38 | Fri Jan 21 | vsPenguins | L2-5 | 18-19-1 | 37 PTS | Nationwide Arena · Columbus, OH |
| 39 | Sun Jan 23 | vsSenators | L1-2 | 18-20-1 | 37 PTS | Nationwide Arena · Columbus, OH |
| 40 | Wed Jan 26 | vsFlames | L0-6 | 18-21-1 | 37 PTS | Nationwide Arena · Columbus, OH |
| 41 | Thu Jan 27 | vsRangers | W5-3 | 19-21-1 | 39 PTS | Nationwide Arena · Columbus, OH |
| 42 | Sun Jan 30 | atCanadiens | W6-3 | 20-21-1 | 41 PTS | Bell Centre · Montreal, QC |
| 43 | Mon Jan 31 | vsPanthers | L4-8 | 20-22-1 | 41 PTS | Nationwide Arena · Columbus, OH |
| 44 | Tue Feb 8 | atCapitals | W5-4 | 21-22-1 | 43 PTS | Capital One Arena · Washington, D.C. |
| 45 | Thu Feb 10 | atSabres | W4-3 (OT) | 22-22-1 | 45 PTS | KeyBank Center · Buffalo, NY |
| 46 | Sat Feb 12 | atCanadiens | W2-1 | 23-22-1 | 47 PTS | Bell Centre · Montreal, QC |
| 47 | Tue Feb 15 | atFlames | L2-6 | 23-23-1 | 47 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 48 | Thu Feb 17 | atBlackhawks | W7-4 | 24-23-1 | 49 PTS | United Center · Chicago, IL |
| 49 | Sun Feb 20 | vsSabres | W7-3 | 25-23-1 | 51 PTS | Nationwide Arena · Columbus, OH |
| 50 | Tue Feb 22 | vsMaple Leafs | W4-3 (OT) | 26-23-1 | 53 PTS | Nationwide Arena · Columbus, OH |
| 51 | Thu Feb 24 | atPanthers | W6-3 | 27-23-1 | 55 PTS | Amerant Bank Arena · Sunrise, FL |
| 52 | Fri Feb 25 | atHurricanes | L0-4 | 27-24-1 | 55 PTS | PNC Arena · Raleigh, NC |
| 53 | Sun Feb 27 | vsPenguins | L2-3 | 27-25-1 | 55 PTS | Nationwide Arena · Columbus, OH |
| 54 | Tue Mar 1 | vsDevils | W4-3 | 28-25-1 | 57 PTS | Nationwide Arena · Columbus, OH |
| 55 | Fri Mar 4 | vsKings | L3-4 (OT) | 28-25-2 | 58 PTS | Nationwide Arena · Columbus, OH |
| 56 | Sat Mar 5 | vsBruins | L4-5 (SO) | 28-25-3 | 59 PTS | Nationwide Arena · Columbus, OH |
| 57 | Mon Mar 7 | vsMaple Leafs | L4-5 | 28-26-3 | 59 PTS | Nationwide Arena · Columbus, OH |
| 58 | Thu Mar 10 | atIslanders | L0-6 | 28-27-3 | 59 PTS | UBS Arena · Elmont, NY |
| 59 | Fri Mar 11 | vsWild | W3-2 (SO) | 29-27-3 | 61 PTS | Nationwide Arena · Columbus, OH |
| 60 | Sun Mar 13 | vsKnights | W6-4 | 30-27-3 | 63 PTS | Nationwide Arena · Columbus, OH |
| 61 | Wed Mar 16 | atSenators | W4-1 | 31-27-3 | 65 PTS | Canadian Tire Centre · Ottawa, ON |
| 62 | Thu Mar 17 | vsCapitals | L2-7 | 31-28-3 | 65 PTS | Nationwide Arena · Columbus, OH |
| 63 | Sat Mar 19 | vsBlues | W5-4 | 32-28-3 | 67 PTS | Nationwide Arena · Columbus, OH |
| 64 | Tue Mar 22 | atPenguins | L1-5 | 32-29-3 | 67 PTS | PPG Paints Arena · Pittsburgh, PA |
| 65 | Fri Mar 25 | atJets | L3-4 (OT) | 32-29-4 | 68 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 66 | Sat Mar 26 | atWild | L2-3 (OT) | 32-29-5 | 69 PTS | Xcel Energy Center · St. Paul, MN |
| 67 | Tue Mar 29 | vsIslanders | L3-4 | 32-30-5 | 69 PTS | Nationwide Arena · Columbus, OH |
| 68 | Thu Mar 31 | atIslanders | L2-5 | 32-31-5 | 69 PTS | UBS Arena · Elmont, NY |
| 69 | Sat Apr 2 | atBruins | L2-5 | 32-32-5 | 69 PTS | TD Garden · Boston, MA |
| 70 | Mon Apr 4 | vsBruins | L2-3 (OT) | 32-32-6 | 70 PTS | Nationwide Arena · Columbus, OH |
| 71 | Tue Apr 5 | atFlyers | W4-2 | 33-32-6 | 72 PTS | Wells Fargo Center · Philadelphia, PA |
| 72 | Thu Apr 7 | vsFlyers | L1-4 | 33-33-6 | 72 PTS | Nationwide Arena · Columbus, OH |
| 73 | Sat Apr 9 | atRed Wings | W5-4 (OT) | 34-33-6 | 74 PTS | Little Caesars Arena · Detroit, MI |
| 74 | Wed Apr 13 | vsCanadiens | W5-1 | 35-33-6 | 76 PTS | Nationwide Arena · Columbus, OH |
| 75 | Sat Apr 16 | atKings | L1-2 | 35-34-6 | 76 PTS | Crypto.com Arena · Los Angeles, CA |
| 76 | Sun Apr 17 | atDucks | L4-6 | 35-35-6 | 76 PTS | Honda Center · Anaheim, CA |
| 77 | Tue Apr 19 | atSharks | L2-3 | 35-36-6 | 76 PTS | SAP Center · San Jose, CA |
| 78 | Fri Apr 22 | vsSenators | L1-2 (SO) | 35-36-7 | 77 PTS | Nationwide Arena · Columbus, OH |
| 79 | Sun Apr 24 | vsOilers | W5-2 | 36-36-7 | 79 PTS | Nationwide Arena · Columbus, OH |
| 80 | Tue Apr 26 | atLightning | L1-4 | 36-37-7 | 79 PTS | AMALIE Arena · Tampa, FL |
| 81 | Thu Apr 28 | vsLightning | W5-2 | 37-37-7 | 81 PTS | Nationwide Arena · Columbus, OH |
| 82 | Fri Apr 29 | atPenguins | L3-5 | 37-38-7 | 81 PTS | PPG Paints Arena · Pittsburgh, PA |
