| 1 | Wed Oct 9 | at Penguins | W6-0 | 1-0-0 | 2 PTS | PPG Paints Arena · Pittsburgh, PA |
| 2 | Sat Oct 12 | vs Utah HC | L5-6 (OT) | 1-0-1 | 3 PTS | Madison Square Garden · Manhattan, NY |
| 3 | Mon Oct 14 | vs Red Wings | W4-1 | 2-0-1 | 5 PTS | Madison Square Garden · Manhattan, NY |
| 4 | Thu Oct 17 | atRed Wings | W5-2 | 3-0-1 | 7 PTS | Little Caesars Arena · Detroit, MI |
| 5 | Sat Oct 19 | at Maple Leafs | W4-1 | 4-0-1 | 9 PTS | Scotiabank Arena · Toronto, ON |
| 6 | Tue Oct 22 | at Canadiens | W7-2 | 5-0-1 | 11 PTS | Bell Centre · Montreal, QC |
| 7 | Thu Oct 24 | vs Panthers | L1-3 | 5-1-1 | 11 PTS | Madison Square Garden · Manhattan, NY |
| 8 | Sat Oct 26 | vs Ducks | W2-1 | 6-1-1 | 13 PTS | Madison Square Garden · Manhattan, NY |
| 9 | Tue Oct 29 | at Capitals | L3-5 | 6-2-1 | 13 PTS | Capital One Arena · Washington, D.C. |
| 10 | Fri Nov 1 | vs Senators | W2-1 | 7-2-1 | 15 PTS | Madison Square Garden · Manhattan, NY |
| 11 | Sun Nov 3 | vs Islanders | W5-2 | 8-2-1 | 17 PTS | Madison Square Garden · Manhattan, NY |
| 12 | Thu Nov 7 | vs Sabres | L1-6 | 8-3-1 | 17 PTS | Madison Square Garden · Manhattan, NY |
| 13 | Sat Nov 9 | atRed Wings | W4-0 | 9-3-1 | 19 PTS | Little Caesars Arena · Detroit, MI |
| 14 | Tue Nov 12 | vs Jets | L3-6 | 9-4-1 | 19 PTS | Madison Square Garden · Manhattan, NY |
| 15 | Thu Nov 14 | vs Sharks | W3-2 | 10-4-1 | 21 PTS | Madison Square Garden · Manhattan, NY |
| 16 | Sun Nov 17 | at Kraken | W2-0 | 11-4-1 | 23 PTS | Climate Pledge Arena · Seattle, WA |
| 17 | Tue Nov 19 | at Canucks | W4-3 | 12-4-1 | 25 PTS | Rogers Arena · Vancouver, British Columbia |
| 18 | Thu Nov 21 | at Flames | L2-3 | 12-5-1 | 25 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 19 | Sat Nov 23 | at Oilers | L2-6 | 12-6-1 | 25 PTS | Rogers Place · Edmonton, AB |
| 20 | Mon Nov 25 | vs Blues | L2-5 | 12-7-1 | 25 PTS | Madison Square Garden · Manhattan, NY |
| 21 | Wed Nov 27 | at Hurricanes | L3-4 | 12-8-1 | 25 PTS | PNC Arena · Raleigh, NC |
| 22 | Fri Nov 29 | at Flyers | L1-3 | 12-9-1 | 25 PTS | Wells Fargo Center · Philadelphia, PA |
| 23 | Sat Nov 30 | vsCanadiens | W4-3 | 13-9-1 | 27 PTS | Madison Square Garden · Manhattan, NY |
| 24 | Mon Dec 2 | vs Devils | L1-5 | 13-10-1 | 27 PTS | Madison Square Garden · Manhattan, NY |
| 25 | Fri Dec 6 | vsPenguins | W4-2 | 14-10-1 | 29 PTS | Madison Square Garden · Manhattan, NY |
| 26 | Sun Dec 8 | vsKraken | L5-7 | 14-11-1 | 29 PTS | Madison Square Garden · Manhattan, NY |
| 27 | Mon Dec 9 | vs Blackhawks | L1-2 | 14-12-1 | 29 PTS | Madison Square Garden · Manhattan, NY |
| 28 | Wed Dec 11 | atSabres | W3-2 | 15-12-1 | 31 PTS | KeyBank Center · Buffalo, NY |
| 29 | Sat Dec 14 | vs Kings | L1-5 | 15-13-1 | 31 PTS | Madison Square Garden · Manhattan, NY |
| 30 | Sun Dec 15 | atBlues | L2-3 | 15-14-1 | 31 PTS | Enterprise Center · St. Louis, MO |
| 31 | Tue Dec 17 | at Predators | L0-2 | 15-15-1 | 31 PTS | Bridgestone Arena · Nashville, TN |
| 32 | Fri Dec 20 | at Stars | W3-1 | 16-15-1 | 33 PTS | American Airlines Center · Dallas, TX |
| 33 | Sun Dec 22 | vsHurricanes | L1-3 | 16-16-1 | 33 PTS | Madison Square Garden · Manhattan, NY |
| 34 | Mon Dec 23 | atDevils | L0-5 | 16-17-1 | 33 PTS | Prudential Center · Newark, NJ |
| 35 | Sat Dec 28 | at Lightning | L2-6 | 16-18-1 | 33 PTS | AMALIE Arena · Tampa, FL |
| 36 | Mon Dec 30 | atPanthers | L3-5 | 16-19-1 | 33 PTS | Amerant Bank Arena · Sunrise, FL |
| 37 | Thu Jan 2 | vs Bruins | W2-1 | 17-19-1 | 35 PTS | Madison Square Garden · Manhattan, NY |
| 38 | Sat Jan 4 | atCapitals | L4-7 | 17-20-1 | 35 PTS | Capital One Arena · Washington, D.C. |
| 39 | Sun Jan 5 | atBlackhawks | W6-2 | 18-20-1 | 37 PTS | United Center · Chicago, IL |
| 40 | Tue Jan 7 | vsStars | L4-5 (OT) | 18-20-2 | 38 PTS | Madison Square Garden · Manhattan, NY |
| 41 | Thu Jan 9 | vsDevils | W3-2 (OT) | 19-20-2 | 40 PTS | Madison Square Garden · Manhattan, NY |
| 42 | Sat Jan 11 | at Knights | W2-1 | 20-20-2 | 42 PTS | T-Mobile Arena · Las Vegas, NV |
| 43 | Tue Jan 14 | at Avalanche | L2-3 (OT) | 20-20-3 | 43 PTS | Ball Arena · Denver, CO |
| 44 | Thu Jan 16 | atUtah HC | W5-3 | 21-20-3 | 45 PTS | Delta Center · Salt Lake City, UT |
| 45 | Sat Jan 18 | vs Jackets | W1-0 (SO) | 22-20-3 | 47 PTS | Madison Square Garden · Manhattan, NY |
| 46 | Sun Jan 19 | atCanadiens | L4-5 (OT) | 22-20-4 | 48 PTS | Bell Centre · Montreal, QC |
| 47 | Tue Jan 21 | vsSenators | W5-0 | 23-20-4 | 50 PTS | Madison Square Garden · Manhattan, NY |
| 48 | Thu Jan 23 | vsFlyers | W6-1 | 24-20-4 | 52 PTS | Madison Square Garden · Manhattan, NY |
| 49 | Sun Jan 26 | vsAvalanche | L4-5 | 24-21-4 | 52 PTS | Madison Square Garden · Manhattan, NY |
| 50 | Tue Jan 28 | vsHurricanes | L0-4 | 24-22-4 | 52 PTS | Madison Square Garden · Manhattan, NY |
| 51 | Sat Feb 1 | atBruins | L3-6 | 24-23-4 | 52 PTS | TD Garden · Boston, MA |
| 52 | Sun Feb 2 | vsKnights | W4-2 | 25-23-4 | 54 PTS | Madison Square Garden · Manhattan, NY |
| 53 | Wed Feb 5 | vsBruins | W3-2 | 26-23-4 | 56 PTS | Madison Square Garden · Manhattan, NY |
| 54 | Fri Feb 7 | vsPenguins | L2-3 | 26-24-4 | 56 PTS | Madison Square Garden · Manhattan, NY |
| 55 | Sat Feb 8 | atJackets | W4-3 | 27-24-4 | 58 PTS | Nationwide Arena · Columbus, OH |
| 56 | Sat Feb 22 | atSabres | L2-8 | 27-25-4 | 58 PTS | KeyBank Center · Buffalo, NY |
| 57 | Sun Feb 23 | atPenguins | W5-3 | 28-25-4 | 60 PTS | PPG Paints Arena · Pittsburgh, PA |
| 58 | Tue Feb 25 | atIslanders | W5-1 | 29-25-4 | 62 PTS | UBS Arena · Elmont, NY |
| 59 | Fri Feb 28 | vsMaple Leafs | L2-3 | 29-26-4 | 62 PTS | Madison Square Garden · Manhattan, NY |
| 60 | Sun Mar 2 | vsPredators | W4-0 | 30-26-4 | 64 PTS | Madison Square Garden · Manhattan, NY |
| 61 | Mon Mar 3 | vsIslanders | W4-0 | 31-26-4 | 66 PTS | Madison Square Garden · Manhattan, NY |
| 62 | Wed Mar 5 | vsCapitals | L2-3 (OT) | 31-26-5 | 67 PTS | Madison Square Garden · Manhattan, NY |
| 63 | Sat Mar 8 | atSenators | L3-4 (OT) | 31-26-6 | 68 PTS | Canadian Tire Centre · Ottawa, ON |
| 64 | Sun Mar 9 | vsJackets | L3-7 | 31-27-6 | 68 PTS | Madison Square Garden · Manhattan, NY |
| 65 | Tue Mar 11 | atJets | L1-2 | 31-28-6 | 68 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 66 | Thu Mar 13 | at Wild | W3-2 (OT) | 32-28-6 | 70 PTS | Xcel Energy Center · St. Paul, MN |
| 67 | Sat Mar 15 | atJackets | W4-0 | 33-28-6 | 72 PTS | Nationwide Arena · Columbus, OH |
| 68 | Sun Mar 16 | vsOilers | L1-3 | 33-29-6 | 72 PTS | Madison Square Garden · Manhattan, NY |
| 69 | Tue Mar 18 | vsFlames | L1-2 | 33-30-6 | 72 PTS | Madison Square Garden · Manhattan, NY |
| 70 | Thu Mar 20 | vsMaple Leafs | L3-4 | 33-31-6 | 72 PTS | Madison Square Garden · Manhattan, NY |
| 71 | Sat Mar 22 | vsCanucks | W5-3 | 34-31-6 | 74 PTS | Madison Square Garden · Manhattan, NY |
| 72 | Tue Mar 25 | atKings | LIVE1-2 | 34-31-6 | 74 PTS | Crypto.com Arena · Los Angeles, CA |
