| 1 | Tue Oct 7 | vs Penguins | L0-3 | 0-1-0 | 0 PTS | Madison Square Garden · Manhattan, NY |
| 2 | Thu Oct 9 | atSabres | W4-0 | 1-1-0 | 2 PTS | KeyBank Center · Buffalo, NY |
| 3 | Sat Oct 11 | atPenguins | W6-1 | 2-1-0 | 4 PTS | PPG Paints Arena · Pittsburgh, PA |
| 4 | Sun Oct 12 | vsCapitals | L0-1 | 2-2-0 | 4 PTS | Madison Square Garden · Manhattan, NY |
| 5 | Tue Oct 14 | vsOilers | L0-2 | 2-3-0 | 4 PTS | Madison Square Garden · Manhattan, NY |
| 6 | Thu Oct 16 | atMaple Leafs | L1-2 (OT) | 2-3-1 | 5 PTS | Scotiabank Arena · Toronto, ON |
| 7 | Sat Oct 18 | atCanadiens | W4-3 | 3-3-1 | 7 PTS | Bell Centre · Montreal, QC |
| 8 | Mon Oct 20 | vsWild | L1-3 | 3-4-1 | 7 PTS | Madison Square Garden · Manhattan, NY |
| 9 | Thu Oct 23 | vsSharks | L5-6 (OT) | 3-4-2 | 8 PTS | Madison Square Garden · Manhattan, NY |
| 10 | Sun Oct 26 | atFlames | L1-5 | 3-5-2 | 8 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 11 | Tue Oct 28 | atCanucks | W2-0 | 4-5-2 | 10 PTS | Rogers Arena · Vancouver, British Columbia |
| 12 | Thu Oct 30 | atOilers | W4-3 (OT) | 5-5-2 | 12 PTS | Rogers Place · Edmonton, AB |
| 13 | Sat Nov 1 | atKraken | W3-2 (OT) | 6-5-2 | 14 PTS | Climate Pledge Arena · Seattle, WA |
| 14 | Tue Nov 4 | vsHurricanes | L0-3 | 6-6-2 | 14 PTS | Madison Square Garden · Manhattan, NY |
| 15 | Fri Nov 7 | atRed Wings | W4-1 | 7-6-2 | 16 PTS | Little Caesars Arena · Detroit, MI |
| 16 | Sat Nov 8 | vsIslanders | L0-5 | 7-7-2 | 16 PTS | Madison Square Garden · Manhattan, NY |
| 17 | Mon Nov 10 | vsPredators | W6-3 | 8-7-2 | 18 PTS | Madison Square Garden · Manhattan, NY |
| 18 | Wed Nov 12 | atLightning | W7-3 | 9-7-2 | 20 PTS | Benchmark International Arena · Tampa, FL |
| 19 | Sat Nov 15 | atJackets | W2-1 (SO) | 10-7-2 | 22 PTS | Nationwide Arena · Columbus, OH |
| 20 | Sun Nov 16 | vsRed Wings | L1-2 | 10-8-2 | 22 PTS | Madison Square Garden · Manhattan, NY |
| 21 | Tue Nov 18 | atKnights | L2-3 | 10-9-2 | 22 PTS | T-Mobile Arena · Las Vegas, NV |
| 22 | Thu Nov 20 | atAvalanche | L3-6 | 10-10-2 | 22 PTS | Ball Arena · Denver, CO |
| 23 | Sat Nov 22 | atMammoth | L2-3 | 10-11-2 | 22 PTS | Delta Center · Salt Lake City, UT |
| 24 | Mon Nov 24 | vsBlues | W3-2 | 11-11-2 | 24 PTS | Madison Square Garden · Manhattan, NY |
| 25 | Wed Nov 26 | atHurricanes | W4-2 | 12-11-2 | 26 PTS | PNC Arena · Raleigh, NC |
| 26 | Fri Nov 28 | atBruins | W6-2 | 13-11-2 | 28 PTS | TD Garden · Boston, MA |
| 27 | Sat Nov 29 | vsLightning | L1-4 | 13-12-2 | 28 PTS | Madison Square Garden · Manhattan, NY |
| 28 | Tue Dec 2 | vsStars | W3-2 (OT) | 14-12-2 | 30 PTS | Madison Square Garden · Manhattan, NY |
| 29 | Thu Dec 4 | atSenators | W4-2 | 15-12-2 | 32 PTS | Canadian Tire Centre · Ottawa, ON |
| 30 | Sat Dec 6 | vsAvalanche | L2-3 (OT) | 15-12-3 | 33 PTS | Madison Square Garden · Manhattan, NY |
| 31 | Sun Dec 7 | vsKnights | L2-3 (OT) | 15-12-4 | 34 PTS | Madison Square Garden · Manhattan, NY |
| 32 | Wed Dec 10 | atBlackhawks | L0-3 | 15-13-4 | 34 PTS | United Center · Chicago, IL |
| 33 | Sat Dec 13 | vsCanadiens | W5-4 (OT) | 16-13-4 | 36 PTS | Madison Square Garden · Manhattan, NY |
| 34 | Mon Dec 15 | vsDucks | L1-4 | 16-14-4 | 36 PTS | Madison Square Garden · Manhattan, NY |
| 35 | Tue Dec 16 | vsCanucks | L0-3 | 16-15-4 | 36 PTS | Madison Square Garden · Manhattan, NY |
| 36 | Thu Dec 18 | atBlues | W2-1 (OT) | 17-15-4 | 38 PTS | Enterprise Center · St. Louis, MO |
| 37 | Sat Dec 20 | vsFlyers | W5-4 (SO) | 18-15-4 | 40 PTS | Madison Square Garden · Manhattan, NY |
| 38 | Sun Dec 21 | atPredators | L1-2 | 18-16-4 | 40 PTS | Bridgestone Arena · Nashville, TN |
| 39 | Tue Dec 23 | atCapitals | W7-3 | 19-16-4 | 42 PTS | Capital One Arena · Washington, D.C. |
| 40 | Sat Dec 27 | atIslanders | L0-2 | 19-17-4 | 42 PTS | UBS Arena · Elmont, NY |
| 41 | Mon Dec 29 | atHurricanes | L2-3 (OT) | 19-17-5 | 43 PTS | PNC Arena · Raleigh, NC |
| 42 | Wed Dec 31 | atCapitals | L3-6 | 19-18-5 | 43 PTS | Capital One Arena · Washington, D.C. |
| 43 | Fri Jan 2 | atPanthers | W5-1 | 20-18-5 | 45 PTS | Amerant Bank Arena · Sunrise, FL |
| 44 | Mon Jan 5 | vsMammoth | L2-3 (OT) | 20-18-6 | 46 PTS | Madison Square Garden · Manhattan, NY |
| 45 | Thu Jan 8 | vsSabres | L2-5 | 20-19-6 | 46 PTS | Madison Square Garden · Manhattan, NY |
| 46 | Sat Jan 10 | atBruins | L2-10 | 20-20-6 | 46 PTS | TD Garden · Boston, MA |
| 47 | Mon Jan 12 | vsKraken | L2-4 | 20-21-6 | 46 PTS | Madison Square Garden · Manhattan, NY |
| 48 | Wed Jan 14 | vsSenators | L4-8 | 20-22-6 | 46 PTS | Madison Square Garden · Manhattan, NY |
| 49 | Sat Jan 17 | atFlyers | W6-3 | 21-22-6 | 48 PTS | Wells Fargo Center · Philadelphia, PA |
| 50 | Mon Jan 19 | atDucks | L3-5 | 21-23-6 | 48 PTS | Honda Center · Anaheim, CA |
| 51 | Tue Jan 20 | atKings | L3-4 | 21-24-6 | 48 PTS | Crypto.com Arena · Los Angeles, CA |
| 52 | Fri Jan 23 | atSharks | L1-3 | 21-25-6 | 48 PTS | SAP Center · San Jose, CA |
| 53 | Mon Jan 26 | vsBruins | W4-3 (OT) | 22-25-6 | 50 PTS | Madison Square Garden · Manhattan, NY |
| 54 | Wed Jan 28 | atIslanders | L2-5 | 22-26-6 | 50 PTS | UBS Arena · Elmont, NY |
| 55 | Thu Jan 29 | vsIslanders | L1-2 | 22-27-6 | 50 PTS | Madison Square Garden · Manhattan, NY |
| 56 | Sat Jan 31 | atPenguins | L5-6 | 22-28-6 | 50 PTS | PPG Paints Arena · Pittsburgh, PA |
| 57 | Thu Feb 5 | vsHurricanes | L0-2 | 22-29-6 | 50 PTS | Madison Square Garden · Manhattan, NY |
| 58 | Thu Feb 26 | vsFlyers | L2-3 (OT) | 22-29-7 | 51 PTS | Madison Square Garden · Manhattan, NY |
| 59 | Sat Feb 28 | vsPenguins | W3-2 (SO) | 23-29-7 | 53 PTS | Madison Square Garden · Manhattan, NY |
