| 1 | Tue Oct 11 | vs Lightning | W3-1 | 1-0-0 | 2 PTS | Madison Square Garden · Manhattan, NY |
| 2 | Thu Oct 13 | atWild | W7-3 | 2-0-0 | 4 PTS | Xcel Energy Center · St. Paul, MN |
| 3 | Fri Oct 14 | atJets | L1-4 | 2-1-0 | 4 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 4 | Mon Oct 17 | vsDucks | W6-4 | 3-1-0 | 6 PTS | Madison Square Garden · Manhattan, NY |
| 5 | Thu Oct 20 | vsSharks | L2-3 (OT) | 3-1-1 | 7 PTS | Madison Square Garden · Manhattan, NY |
| 6 | Sun Oct 23 | vsJackets | L1-5 | 3-2-1 | 7 PTS | Madison Square Garden · Manhattan, NY |
| 7 | Tue Oct 25 | vsAvalanche | L2-3 (SO) | 3-2-2 | 8 PTS | Madison Square Garden · Manhattan, NY |
| 8 | Wed Oct 26 | atIslanders | L0-3 | 3-3-2 | 8 PTS | UBS Arena · Elmont, NY |
| 9 | Sat Oct 29 | atStars | W6-3 | 4-3-2 | 10 PTS | American Airlines Center · Dallas, TX |
| 10 | Sun Oct 30 | atCoyotes | W3-2 | 5-3-2 | 12 PTS | Mullett Arena · Tempe, AZ |
| 11 | Tue Nov 1 | vsFlyers | W1-0 (OT) | 6-3-2 | 14 PTS | Madison Square Garden · Manhattan, NY |
| 12 | Thu Nov 3 | vsBruins | L2-5 | 6-4-2 | 14 PTS | Madison Square Garden · Manhattan, NY |
| 13 | Sun Nov 6 | vsRed Wings | L2-3 (OT) | 6-4-3 | 15 PTS | Madison Square Garden · Manhattan, NY |
| 14 | Tue Nov 8 | vsIslanders | L3-4 | 6-5-3 | 15 PTS | Madison Square Garden · Manhattan, NY |
| 15 | Thu Nov 10 | atRed Wings | W8-2 | 7-5-3 | 17 PTS | Little Caesars Arena · Detroit, MI |
| 16 | Sat Nov 12 | atPredators | L1-2 | 7-6-3 | 17 PTS | Bridgestone Arena · Nashville, TN |
| 17 | Sun Nov 13 | vsCoyotes | W4-1 | 8-6-3 | 19 PTS | Madison Square Garden · Manhattan, NY |
| 18 | Thu Nov 17 | atKraken | L2-3 (OT) | 8-6-4 | 20 PTS | Climate Pledge Arena · Seattle, WA |
| 19 | Sat Nov 19 | atSharks | W2-1 | 9-6-4 | 22 PTS | SAP Center · San Jose, CA |
| 20 | Tue Nov 22 | atKings | W5-3 | 10-6-4 | 24 PTS | Crypto.com Arena · Los Angeles, CA |
| 21 | Wed Nov 23 | atDucks | L2-3 | 10-7-4 | 24 PTS | Honda Center · Anaheim, CA |
| 22 | Sat Nov 26 | vsOilers | L3-4 | 10-8-4 | 24 PTS | Madison Square Garden · Manhattan, NY |
| 23 | Mon Nov 28 | vsDevils | L3-5 | 10-9-4 | 24 PTS | Madison Square Garden · Manhattan, NY |
| 24 | Wed Nov 30 | atSenators | W3-1 | 11-9-4 | 26 PTS | Canadian Tire Centre · Ottawa, ON |
| 25 | Fri Dec 2 | vsSenators | L2-3 (OT) | 11-9-5 | 27 PTS | Madison Square Garden · Manhattan, NY |
| 26 | Sat Dec 3 | vsBlackhawks | L2-5 | 11-10-5 | 27 PTS | Madison Square Garden · Manhattan, NY |
| 27 | Mon Dec 5 | vsBlues | W6-4 | 12-10-5 | 29 PTS | Madison Square Garden · Manhattan, NY |
| 28 | Wed Dec 7 | atKnights | W5-1 | 13-10-5 | 31 PTS | T-Mobile Arena · Las Vegas, NV |
| 29 | Fri Dec 9 | atAvalanche | W2-1 (SO) | 14-10-5 | 33 PTS | Ball Arena · Denver, CO |
| 30 | Mon Dec 12 | vsDevils | W4-3 (OT) | 15-10-5 | 35 PTS | Madison Square Garden · Manhattan, NY |
| 31 | Thu Dec 15 | vsMaple Leafs | W3-1 | 16-10-5 | 37 PTS | Madison Square Garden · Manhattan, NY |
| 32 | Sat Dec 17 | atFlyers | W6-3 | 17-10-5 | 39 PTS | Wells Fargo Center · Philadelphia, PA |
| 33 | Sun Dec 18 | atBlackhawks | W7-1 | 18-10-5 | 41 PTS | United Center · Chicago, IL |
| 34 | Tue Dec 20 | atPenguins | L2-3 | 18-11-5 | 41 PTS | PPG Paints Arena · Pittsburgh, PA |
| 35 | Thu Dec 22 | vsIslanders | W5-3 | 19-11-5 | 43 PTS | Madison Square Garden · Manhattan, NY |
| 36 | Tue Dec 27 | vsCapitals | L0-4 | 19-12-5 | 43 PTS | Madison Square Garden · Manhattan, NY |
| 37 | Thu Dec 29 | atLightning | L1-2 (SO) | 19-12-6 | 44 PTS | AMALIE Arena · Tampa, FL |
| 38 | Sun Jan 1 | atPanthers | W5-3 | 20-12-6 | 46 PTS | Amerant Bank Arena · Sunrise, FL |
| 39 | Tue Jan 3 | vsHurricanes | W5-3 | 21-12-6 | 48 PTS | Madison Square Garden · Manhattan, NY |
| 40 | Thu Jan 5 | atCanadiens | W4-1 | 22-12-6 | 50 PTS | Bell Centre · Montreal, QC |
| 41 | Sat Jan 7 | atDevils | L3-4 (OT) | 22-12-7 | 51 PTS | Prudential Center · Newark, NJ |
| 42 | Tue Jan 10 | vsWild | W4-3 (SO) | 23-12-7 | 53 PTS | Madison Square Garden · Manhattan, NY |
| 43 | Thu Jan 12 | vsStars | W2-1 (OT) | 24-12-7 | 55 PTS | Madison Square Garden · Manhattan, NY |
| 44 | Sun Jan 15 | vsCanadiens | L1-2 | 24-13-7 | 55 PTS | Madison Square Garden · Manhattan, NY |
| 45 | Mon Jan 16 | atJackets | W3-1 | 25-13-7 | 57 PTS | Nationwide Arena · Columbus, OH |
| 46 | Thu Jan 19 | vsBruins | L1-3 | 25-14-7 | 57 PTS | Madison Square Garden · Manhattan, NY |
| 47 | Mon Jan 23 | vsPanthers | W6-2 | 26-14-7 | 59 PTS | Madison Square Garden · Manhattan, NY |
| 48 | Wed Jan 25 | atMaple Leafs | L2-3 (OT) | 26-14-8 | 60 PTS | Scotiabank Arena · Toronto, ON |
| 49 | Fri Jan 27 | vsKnights | W4-1 | 27-14-8 | 62 PTS | Madison Square Garden · Manhattan, NY |
| 50 | Mon Feb 6 | vsFlames | W5-4 (OT) | 28-14-8 | 64 PTS | Madison Square Garden · Manhattan, NY |
| 51 | Wed Feb 8 | vsCanucks | W4-3 | 29-14-8 | 66 PTS | Madison Square Garden · Manhattan, NY |
| 52 | Fri Feb 10 | vsKraken | W6-3 | 30-14-8 | 68 PTS | Madison Square Garden · Manhattan, NY |
| 53 | Sat Feb 11 | atHurricanes | W6-2 | 31-14-8 | 70 PTS | PNC Arena · Raleigh, NC |
| 54 | Wed Feb 15 | atCanucks | W6-4 | 32-14-8 | 72 PTS | Rogers Arena · Vancouver, British Columbia |
| 55 | Fri Feb 17 | atOilers | W5-4 (SO) | 33-14-8 | 74 PTS | Rogers Place · Edmonton, AB |
| 56 | Sat Feb 18 | atFlames | L2-3 (OT) | 33-14-9 | 75 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 57 | Mon Feb 20 | vsJets | L1-4 | 33-15-9 | 75 PTS | Madison Square Garden · Manhattan, NY |
| 58 | Thu Feb 23 | atRed Wings | L1-4 | 33-16-9 | 75 PTS | Little Caesars Arena · Detroit, MI |
| 59 | Sat Feb 25 | atCapitals | L3-6 | 33-17-9 | 75 PTS | Capital One Arena · Washington, D.C. |
| 60 | Sun Feb 26 | vsKings | W5-2 | 34-17-9 | 77 PTS | Madison Square Garden · Manhattan, NY |
| 61 | Wed Mar 1 | atFlyers | W3-2 (OT) | 35-17-9 | 79 PTS | Wells Fargo Center · Philadelphia, PA |
| 62 | Thu Mar 2 | vsSenators | L3-5 | 35-18-9 | 79 PTS | Madison Square Garden · Manhattan, NY |
| 63 | Sat Mar 4 | atBruins | L2-4 | 35-19-9 | 79 PTS | TD Garden · Boston, MA |
| 64 | Thu Mar 9 | atCanadiens | W4-3 (SO) | 36-19-9 | 81 PTS | Bell Centre · Montreal, QC |
| 65 | Sat Mar 11 | atSabres | W2-1 (OT) | 37-19-9 | 83 PTS | KeyBank Center · Buffalo, NY |
| 66 | Sun Mar 12 | atPenguins | L2-3 (OT) | 37-19-10 | 84 PTS | PPG Paints Arena · Pittsburgh, PA |
| 67 | Tue Mar 14 | vsCapitals | W5-3 | 38-19-10 | 86 PTS | Madison Square Garden · Manhattan, NY |
| 68 | Thu Mar 16 | vsPenguins | W4-2 | 39-19-10 | 88 PTS | Madison Square Garden · Manhattan, NY |
| 69 | Sat Mar 18 | vsPenguins | W6-0 | 40-19-10 | 90 PTS | Madison Square Garden · Manhattan, NY |
| 70 | Sun Mar 19 | vsPredators | W7-0 | 41-19-10 | 92 PTS | Madison Square Garden · Manhattan, NY |
| 71 | Tue Mar 21 | vsHurricanes | L2-3 | 41-20-10 | 92 PTS | Madison Square Garden · Manhattan, NY |
| 72 | Thu Mar 23 | atHurricanes | W2-1 | 42-20-10 | 94 PTS | PNC Arena · Raleigh, NC |
| 73 | Sat Mar 25 | atPanthers | W4-3 | 43-20-10 | 96 PTS | Amerant Bank Arena · Sunrise, FL |
| 74 | Tue Mar 28 | vsJackets | W6-2 | 44-20-10 | 98 PTS | Madison Square Garden · Manhattan, NY |
| 75 | Thu Mar 30 | atDevils | L1-2 | 44-21-10 | 98 PTS | Prudential Center · Newark, NJ |
| 76 | Fri Mar 31 | atSabres | L2-3 (OT) | 44-21-11 | 99 PTS | KeyBank Center · Buffalo, NY |
| 77 | Sun Apr 2 | atCapitals | W5-2 | 45-21-11 | 101 PTS | Capital One Arena · Washington, D.C. |
| 78 | Wed Apr 5 | vsLightning | W6-3 | 46-21-11 | 103 PTS | Madison Square Garden · Manhattan, NY |
| 79 | Thu Apr 6 | atBlues | L2-3 (OT) | 46-21-12 | 104 PTS | Enterprise Center · St. Louis, MO |
| 80 | Sat Apr 8 | atJackets | W4-0 | 47-21-12 | 106 PTS | Nationwide Arena · Columbus, OH |
| 81 | Mon Apr 10 | vsSabres | L2-3 (SO) | 47-21-13 | 107 PTS | Madison Square Garden · Manhattan, NY |
| 82 | Thu Apr 13 | vsMaple Leafs | L2-3 | 47-22-13 | 107 PTS | Madison Square Garden · Manhattan, NY |
| 1 | Tue Apr 18 | atDevils | W5-1 | 1-0 | 1.000 | Prudential Center · Newark, NJ |
| 2 | Thu Apr 20 | atDevils | W5-1 | 2-0 | 1.000 | Prudential Center · Newark, NJ |
| 3 | Sat Apr 22 | vsDevils | L1-2 (OT) | 2-1 | .667 | Madison Square Garden · Manhattan, NY |
| 4 | Mon Apr 24 | vsDevils | L1-3 | 2-2 | .500 | Madison Square Garden · Manhattan, NY |
| 5 | Thu Apr 27 | atDevils | L0-4 | 2-3 | .400 | Prudential Center · Newark, NJ |
| 6 | Sat Apr 29 | vsDevils | W5-2 | 3-3 | .500 | Madison Square Garden · Manhattan, NY |
| 7 | Mon May 1 | atDevils | L0-4 | 3-4 | .429 | Prudential Center · Newark, NJ |
