| 1 | Wed Oct 13 | at Capitals | L1-5 | 0-1-0 | 0 PTS | Capital One Arena · Washington, D.C. |
| 2 | Thu Oct 14 | vsStars | L2-3 (OT) | 0-1-1 | 1 PTS | Madison Square Garden · Manhattan, NY |
| 3 | Sat Oct 16 | atCanadiens | W3-1 | 1-1-1 | 3 PTS | Bell Centre · Montreal, QC |
| 4 | Mon Oct 18 | atMaple Leafs | W2-1 (OT) | 2-1-1 | 5 PTS | Scotiabank Arena · Toronto, ON |
| 5 | Thu Oct 21 | atPredators | W3-1 | 3-1-1 | 7 PTS | Bridgestone Arena · Nashville, TN |
| 6 | Sat Oct 23 | atSenators | W3-2 | 4-1-1 | 9 PTS | Canadian Tire Centre · Ottawa, ON |
| 7 | Mon Oct 25 | vsFlames | L1-5 | 4-2-1 | 9 PTS | Madison Square Garden · Manhattan, NY |
| 8 | Fri Oct 29 | vsJackets | W4-0 | 5-2-1 | 11 PTS | Madison Square Garden · Manhattan, NY |
| 9 | Sun Oct 31 | atKraken | W3-1 | 6-2-1 | 13 PTS | Climate Pledge Arena · Seattle, WA |
| 10 | Tue Nov 2 | atCanucks | L2-3 (OT) | 6-2-2 | 14 PTS | Rogers Arena · Vancouver, British Columbia |
| 11 | Fri Nov 5 | atOilers | L5-6 (OT) | 6-2-3 | 15 PTS | Rogers Place · Edmonton, AB |
| 12 | Sat Nov 6 | atFlames | L0-6 | 6-3-3 | 15 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 13 | Mon Nov 8 | vsPanthers | W4-3 | 7-3-3 | 17 PTS | Madison Square Garden · Manhattan, NY |
| 14 | Sat Nov 13 | atJackets | W5-3 | 8-3-3 | 19 PTS | Nationwide Arena · Columbus, OH |
| 15 | Sun Nov 14 | vsDevils | W4-3 (SO) | 9-3-3 | 21 PTS | Madison Square Garden · Manhattan, NY |
| 16 | Tue Nov 16 | vsCanadiens | W3-2 | 10-3-3 | 23 PTS | Madison Square Garden · Manhattan, NY |
| 17 | Thu Nov 18 | atMaple Leafs | L1-2 | 10-4-3 | 23 PTS | Scotiabank Arena · Toronto, ON |
| 18 | Sun Nov 21 | vsSabres | W5-4 | 11-4-3 | 25 PTS | Madison Square Garden · Manhattan, NY |
| 19 | Wed Nov 24 | atIslanders | W4-1 | 12-4-3 | 27 PTS | UBS Arena · Elmont, NY |
| 20 | Fri Nov 26 | atBruins | W5-2 | 13-4-3 | 29 PTS | TD Garden · Boston, MA |
| 21 | Wed Dec 1 | vsFlyers | W4-1 | 14-4-3 | 31 PTS | Madison Square Garden · Manhattan, NY |
| 22 | Fri Dec 3 | vsSharks | W1-0 | 15-4-3 | 33 PTS | Madison Square Garden · Manhattan, NY |
| 23 | Sat Dec 4 | vsBlackhawks | W3-2 | 16-4-3 | 35 PTS | Madison Square Garden · Manhattan, NY |
| 24 | Tue Dec 7 | atBlackhawks | W6-2 | 17-4-3 | 37 PTS | United Center · Chicago, IL |
| 25 | Wed Dec 8 | vsAvalanche | L3-7 | 17-5-3 | 37 PTS | Madison Square Garden · Manhattan, NY |
| 26 | Fri Dec 10 | atSabres | W2-1 | 18-5-3 | 39 PTS | KeyBank Center · Buffalo, NY |
| 27 | Sun Dec 12 | vsPredators | L0-1 | 18-6-3 | 39 PTS | Madison Square Garden · Manhattan, NY |
| 28 | Tue Dec 14 | atAvalanche | L2-4 | 18-7-3 | 39 PTS | Ball Arena · Denver, CO |
| 29 | Wed Dec 15 | atCoyotes | W3-2 | 19-7-3 | 41 PTS | Mullett Arena · Tempe, AZ |
| 30 | Fri Dec 17 | vsKnights | L2-3 (SO) | 19-7-4 | 42 PTS | Madison Square Garden · Manhattan, NY |
| 31 | Wed Dec 29 | atPanthers | L3-4 | 19-8-4 | 42 PTS | Amerant Bank Arena · Sunrise, FL |
| 32 | Fri Dec 31 | atLightning | W4-3 (SO) | 20-8-4 | 44 PTS | AMALIE Arena · Tampa, FL |
| 33 | Sun Jan 2 | vsLightning | W4-0 | 21-8-4 | 46 PTS | Madison Square Garden · Manhattan, NY |
| 34 | Mon Jan 3 | vsOilers | W4-1 | 22-8-4 | 48 PTS | Madison Square Garden · Manhattan, NY |
| 35 | Thu Jan 6 | atKnights | L1-5 | 22-9-4 | 48 PTS | T-Mobile Arena · Las Vegas, NV |
| 36 | Sat Jan 8 | atDucks | W4-1 | 23-9-4 | 50 PTS | Honda Center · Anaheim, CA |
| 37 | Mon Jan 10 | atKings | L1-3 | 23-10-4 | 50 PTS | Crypto.com Arena · Los Angeles, CA |
| 38 | Thu Jan 13 | atSharks | W3-0 | 24-10-4 | 52 PTS | SAP Center · San Jose, CA |
| 39 | Sat Jan 15 | atFlyers | W3-2 | 25-10-4 | 54 PTS | Wells Fargo Center · Philadelphia, PA |
| 40 | Wed Jan 19 | vsMaple Leafs | W6-3 | 26-10-4 | 56 PTS | Madison Square Garden · Manhattan, NY |
| 41 | Fri Jan 21 | atHurricanes | L3-6 | 26-11-4 | 56 PTS | PNC Arena · Raleigh, NC |
| 42 | Sat Jan 22 | vsCoyotes | W7-3 | 27-11-4 | 58 PTS | Madison Square Garden · Manhattan, NY |
| 43 | Mon Jan 24 | vsKings | W3-2 (SO) | 28-11-4 | 60 PTS | Madison Square Garden · Manhattan, NY |
| 44 | Thu Jan 27 | atJackets | L3-5 | 28-12-4 | 60 PTS | Nationwide Arena · Columbus, OH |
| 45 | Fri Jan 28 | vsWild | L2-3 | 28-13-4 | 60 PTS | Madison Square Garden · Manhattan, NY |
| 46 | Sun Jan 30 | vsKraken | W3-2 | 29-13-4 | 62 PTS | Madison Square Garden · Manhattan, NY |
| 47 | Tue Feb 1 | vsPanthers | W5-2 | 30-13-4 | 64 PTS | Madison Square Garden · Manhattan, NY |
| 48 | Tue Feb 15 | vsBruins | W2-1 (SO) | 31-13-4 | 66 PTS | Madison Square Garden · Manhattan, NY |
| 49 | Thu Feb 17 | vsRed Wings | L2-3 (SO) | 31-13-5 | 67 PTS | Madison Square Garden · Manhattan, NY |
| 50 | Sun Feb 20 | atSenators | W2-1 | 32-13-5 | 69 PTS | Canadian Tire Centre · Ottawa, ON |
| 51 | Thu Feb 24 | vsCapitals | W4-1 | 33-13-5 | 71 PTS | Madison Square Garden · Manhattan, NY |
| 52 | Sat Feb 26 | atPenguins | L0-1 | 33-14-5 | 71 PTS | PPG Paints Arena · Pittsburgh, PA |
| 53 | Sun Feb 27 | vsCanucks | L2-5 | 33-15-5 | 71 PTS | Madison Square Garden · Manhattan, NY |
| 54 | Wed Mar 2 | vsBlues | W5-3 | 34-15-5 | 73 PTS | Madison Square Garden · Manhattan, NY |
| 55 | Fri Mar 4 | vsDevils | W3-1 | 35-15-5 | 75 PTS | Madison Square Garden · Manhattan, NY |
| 56 | Sun Mar 6 | atJets | W4-1 | 36-15-5 | 77 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 57 | Tue Mar 8 | atWild | L2-5 | 36-16-5 | 77 PTS | Xcel Energy Center · St. Paul, MN |
| 58 | Thu Mar 10 | atBlues | L2-6 | 36-17-5 | 77 PTS | Enterprise Center · St. Louis, MO |
| 59 | Sat Mar 12 | atStars | W7-4 | 37-17-5 | 79 PTS | American Airlines Center · Dallas, TX |
| 60 | Tue Mar 15 | vsDucks | W4-3 (OT) | 38-17-5 | 81 PTS | Madison Square Garden · Manhattan, NY |
| 61 | Thu Mar 17 | vsIslanders | L1-2 | 38-18-5 | 81 PTS | Madison Square Garden · Manhattan, NY |
| 62 | Sat Mar 19 | atLightning | W2-1 | 39-18-5 | 83 PTS | AMALIE Arena · Tampa, FL |
| 63 | Sun Mar 20 | atHurricanes | W2-0 | 40-18-5 | 85 PTS | PNC Arena · Raleigh, NC |
| 64 | Tue Mar 22 | atDevils | L4-7 | 40-19-5 | 85 PTS | Prudential Center · Newark, NJ |
| 65 | Fri Mar 25 | vsPenguins | W5-1 | 41-19-5 | 87 PTS | Madison Square Garden · Manhattan, NY |
| 66 | Sun Mar 27 | vsSabres | W5-4 (OT) | 42-19-5 | 89 PTS | Madison Square Garden · Manhattan, NY |
| 67 | Tue Mar 29 | atPenguins | W3-2 | 43-19-5 | 91 PTS | PPG Paints Arena · Pittsburgh, PA |
| 68 | Wed Mar 30 | atRed Wings | W5-4 (OT) | 44-19-5 | 93 PTS | Little Caesars Arena · Detroit, MI |
| 69 | Fri Apr 1 | vsIslanders | L0-3 | 44-20-5 | 93 PTS | Madison Square Garden · Manhattan, NY |
| 70 | Sun Apr 3 | vsFlyers | L3-4 (SO) | 44-20-6 | 94 PTS | Madison Square Garden · Manhattan, NY |
| 71 | Tue Apr 5 | atDevils | W3-1 | 45-20-6 | 96 PTS | Prudential Center · Newark, NJ |
| 72 | Thu Apr 7 | vsPenguins | W3-0 | 46-20-6 | 98 PTS | Madison Square Garden · Manhattan, NY |
| 73 | Sat Apr 9 | vsSenators | W5-1 | 47-20-6 | 100 PTS | Madison Square Garden · Manhattan, NY |
| 74 | Tue Apr 12 | vsHurricanes | L2-4 | 47-21-6 | 100 PTS | Madison Square Garden · Manhattan, NY |
| 75 | Wed Apr 13 | atFlyers | W4-0 | 48-21-6 | 102 PTS | Wells Fargo Center · Philadelphia, PA |
| 76 | Sat Apr 16 | vsRed Wings | W4-0 | 49-21-6 | 104 PTS | Madison Square Garden · Manhattan, NY |
| 77 | Tue Apr 19 | vsJets | W3-0 | 50-21-6 | 106 PTS | Madison Square Garden · Manhattan, NY |
| 78 | Thu Apr 21 | atIslanders | W6-3 | 51-21-6 | 108 PTS | UBS Arena · Elmont, NY |
| 79 | Sat Apr 23 | atBruins | L1-3 | 51-22-6 | 108 PTS | TD Garden · Boston, MA |
| 80 | Tue Apr 26 | vsHurricanes | L3-4 | 51-23-6 | 108 PTS | Madison Square Garden · Manhattan, NY |
| 81 | Wed Apr 27 | vsCanadiens | L3-4 | 51-24-6 | 108 PTS | Madison Square Garden · Manhattan, NY |
| 82 | Fri Apr 29 | vsCapitals | W3-2 | 52-24-6 | 110 PTS | Madison Square Garden · Manhattan, NY |
| 1 | Tue May 3 | vsPenguins | L3-4 (OT) | 0-1 | .000 | Madison Square Garden · Manhattan, NY |
| 2 | Thu May 5 | vsPenguins | W5-2 | 1-1 | .500 | Madison Square Garden · Manhattan, NY |
| 3 | Sat May 7 | atPenguins | L4-7 | 1-2 | .333 | PPG Paints Arena · Pittsburgh, PA |
| 4 | Mon May 9 | atPenguins | L2-7 | 1-3 | .250 | PPG Paints Arena · Pittsburgh, PA |
| 5 | Wed May 11 | vsPenguins | W5-3 | 2-3 | .400 | Madison Square Garden · Manhattan, NY |
| 6 | Fri May 13 | atPenguins | W5-3 | 3-3 | .500 | PPG Paints Arena · Pittsburgh, PA |
| 7 | Sun May 15 | vsPenguins | W4-3 (OT) | 4-3 | .571 | Madison Square Garden · Manhattan, NY |
| 1 | Wed May 18 | atHurricanes | L1-2 (OT) | 0-1 | .000 | PNC Arena · Raleigh, NC |
| 2 | Fri May 20 | atHurricanes | L0-2 | 0-2 | .000 | PNC Arena · Raleigh, NC |
| 3 | Sun May 22 | vsHurricanes | W3-1 | 1-2 | .333 | Madison Square Garden · Manhattan, NY |
| 4 | Tue May 24 | vsHurricanes | W4-1 | 2-2 | .500 | Madison Square Garden · Manhattan, NY |
| 5 | Thu May 26 | atHurricanes | L1-3 | 2-3 | .400 | PNC Arena · Raleigh, NC |
| 6 | Sat May 28 | vsHurricanes | W5-2 | 3-3 | .500 | Madison Square Garden · Manhattan, NY |
| 7 | Mon May 30 | atHurricanes | W6-2 | 4-3 | .571 | PNC Arena · Raleigh, NC |
| 1 | Wed Jun 1 | vsLightning | W6-2 | 1-0 | 1.000 | Madison Square Garden · Manhattan, NY |
| 2 | Fri Jun 3 | vsLightning | W3-2 | 2-0 | 1.000 | Madison Square Garden · Manhattan, NY |
| 3 | Sun Jun 5 | atLightning | L2-3 | 2-1 | .667 | AMALIE Arena · Tampa, FL |
| 4 | Tue Jun 7 | atLightning | L1-4 | 2-2 | .500 | AMALIE Arena · Tampa, FL |
| 5 | Thu Jun 9 | vsLightning | L1-3 | 2-3 | .400 | Madison Square Garden · Manhattan, NY |
| 6 | Sat Jun 11 | atLightning | L1-2 | 2-4 | .333 | AMALIE Arena · Tampa, FL |
