| 1 | Thu Oct 12 | at Sabres | W5-1 | 1-0-0 | 2 PTS | KeyBank Center · Buffalo, NY |
| 2 | Sat Oct 14 | atJackets | L3-5 | 1-1-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 3 | Mon Oct 16 | vsCoyotes | W2-1 | 2-1-0 | 4 PTS | Madison Square Garden · Manhattan, NY |
| 4 | Thu Oct 19 | vsPredators | L1-4 | 2-2-0 | 4 PTS | Madison Square Garden · Manhattan, NY |
| 5 | Sat Oct 21 | atKraken | W4-1 | 3-2-0 | 6 PTS | Climate Pledge Arena · Seattle, WA |
| 6 | Tue Oct 24 | atFlames | W3-1 | 4-2-0 | 8 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 7 | Thu Oct 26 | atOilers | W3-0 | 5-2-0 | 10 PTS | Rogers Place · Edmonton, AB |
| 8 | Sat Oct 28 | atCanucks | W4-3 (OT) | 6-2-0 | 12 PTS | Rogers Arena · Vancouver, British Columbia |
| 9 | Mon Oct 30 | atJets | W3-2 (OT) | 7-2-0 | 14 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 10 | Thu Nov 2 | vsHurricanes | W2-1 | 8-2-0 | 16 PTS | Madison Square Garden · Manhattan, NY |
| 11 | Sat Nov 4 | atWild | L4-5 (SO) | 8-2-1 | 17 PTS | Xcel Energy Center · St. Paul, MN |
| 12 | Tue Nov 7 | vsRed Wings | W5-3 | 9-2-1 | 19 PTS | Madison Square Garden · Manhattan, NY |
| 13 | Thu Nov 9 | vsWild | W4-1 | 10-2-1 | 21 PTS | Madison Square Garden · Manhattan, NY |
| 14 | Sun Nov 12 | vsJackets | W4-3 (SO) | 11-2-1 | 23 PTS | Madison Square Garden · Manhattan, NY |
| 15 | Sat Nov 18 | atDevils | W5-3 | 12-2-1 | 25 PTS | Prudential Center · Newark, NJ |
| 16 | Mon Nov 20 | atStars | L3-6 | 12-3-1 | 25 PTS | American Airlines Center · Dallas, TX |
| 17 | Wed Nov 22 | atPenguins | W1-0 | 13-3-1 | 27 PTS | PPG Paints Arena · Pittsburgh, PA |
| 18 | Fri Nov 24 | atFlyers | W3-1 | 14-3-1 | 29 PTS | Wells Fargo Center · Philadelphia, PA |
| 19 | Sat Nov 25 | vsBruins | W7-4 | 15-3-1 | 31 PTS | Madison Square Garden · Manhattan, NY |
| 20 | Mon Nov 27 | vsSabres | L1-5 | 15-4-1 | 31 PTS | Madison Square Garden · Manhattan, NY |
| 21 | Wed Nov 29 | vsRed Wings | W3-2 | 16-4-1 | 33 PTS | Madison Square Garden · Manhattan, NY |
| 22 | Sat Dec 2 | atPredators | W4-3 | 17-4-1 | 35 PTS | Bridgestone Arena · Nashville, TN |
| 23 | Sun Dec 3 | vsSharks | W6-5 | 18-4-1 | 37 PTS | Madison Square Garden · Manhattan, NY |
| 24 | Tue Dec 5 | atSenators | L2-6 | 18-5-1 | 37 PTS | Canadian Tire Centre · Ottawa, ON |
| 25 | Sat Dec 9 | atCapitals | L0-4 | 18-6-1 | 37 PTS | Capital One Arena · Washington, D.C. |
| 26 | Sun Dec 10 | vsKings | W4-1 | 19-6-1 | 39 PTS | Madison Square Garden · Manhattan, NY |
| 27 | Tue Dec 12 | vsMaple Leafs | L3-7 | 19-7-1 | 39 PTS | Madison Square Garden · Manhattan, NY |
| 28 | Fri Dec 15 | vsDucks | W5-1 | 20-7-1 | 41 PTS | Madison Square Garden · Manhattan, NY |
| 29 | Sat Dec 16 | atBruins | W2-1 (OT) | 21-7-1 | 43 PTS | TD Garden · Boston, MA |
| 30 | Tue Dec 19 | atMaple Leafs | W5-2 | 22-7-1 | 45 PTS | Scotiabank Arena · Toronto, ON |
| 31 | Fri Dec 22 | vsOilers | L3-4 | 22-8-1 | 45 PTS | Madison Square Garden · Manhattan, NY |
| 32 | Sat Dec 23 | vsSabres | W4-3 (OT) | 23-8-1 | 47 PTS | Madison Square Garden · Manhattan, NY |
| 33 | Wed Dec 27 | vsCapitals | W5-1 | 24-8-1 | 49 PTS | Madison Square Garden · Manhattan, NY |
| 34 | Fri Dec 29 | atPanthers | L3-4 | 24-9-1 | 49 PTS | Amerant Bank Arena · Sunrise, FL |
| 35 | Sat Dec 30 | atLightning | W5-1 | 25-9-1 | 51 PTS | AMALIE Arena · Tampa, FL |
| 36 | Tue Jan 2 | vsHurricanes | L1-6 | 25-10-1 | 51 PTS | Madison Square Garden · Manhattan, NY |
| 37 | Thu Jan 4 | vsBlackhawks | W4-1 | 26-10-1 | 53 PTS | Madison Square Garden · Manhattan, NY |
| 38 | Sat Jan 6 | atCanadiens | L3-4 (SO) | 26-10-2 | 54 PTS | Bell Centre · Montreal, QC |
| 39 | Mon Jan 8 | vsCanucks | L3-6 | 26-11-2 | 54 PTS | Madison Square Garden · Manhattan, NY |
| 40 | Thu Jan 11 | atBlues | L2-5 | 26-12-2 | 54 PTS | Enterprise Center · St. Louis, MO |
| 41 | Sat Jan 13 | atCapitals | L2-3 | 26-13-2 | 54 PTS | Capital One Arena · Washington, D.C. |
| 42 | Sun Jan 14 | vsCapitals | W2-1 | 27-13-2 | 56 PTS | Madison Square Garden · Manhattan, NY |
| 43 | Tue Jan 16 | vsKraken | W5-2 | 28-13-2 | 58 PTS | Madison Square Garden · Manhattan, NY |
| 44 | Thu Jan 18 | atKnights | L1-5 | 28-14-2 | 58 PTS | T-Mobile Arena · Las Vegas, NV |
| 45 | Sat Jan 20 | atKings | L1-2 | 28-15-2 | 58 PTS | Crypto.com Arena · Los Angeles, CA |
| 46 | Sun Jan 21 | atDucks | W5-2 | 29-15-2 | 60 PTS | Honda Center · Anaheim, CA |
| 47 | Tue Jan 23 | atSharks | L2-3 (OT) | 29-15-3 | 61 PTS | SAP Center · San Jose, CA |
| 48 | Fri Jan 26 | vsKnights | L2-5 | 29-16-3 | 61 PTS | Madison Square Garden · Manhattan, NY |
| 49 | Sat Jan 27 | atSenators | W7-2 | 30-16-3 | 63 PTS | Canadian Tire Centre · Ottawa, ON |
| 50 | Mon Feb 5 | vsAvalanche | W2-1 (OT) | 31-16-3 | 65 PTS | Madison Square Garden · Manhattan, NY |
| 51 | Wed Feb 7 | vsLightning | W3-1 | 32-16-3 | 67 PTS | Madison Square Garden · Manhattan, NY |
| 52 | Fri Feb 9 | atBlackhawks | W4-3 (OT) | 33-16-3 | 69 PTS | United Center · Chicago, IL |
| 53 | Mon Feb 12 | vsFlames | W2-0 | 34-16-3 | 71 PTS | Madison Square Garden · Manhattan, NY |
| 54 | Thu Feb 15 | vsCanadiens | W7-4 | 35-16-3 | 73 PTS | Madison Square Garden · Manhattan, NY |
| 55 | Sun Feb 18 | atIslanders | W6-5 (OT) | 36-16-3 | 75 PTS | UBS Arena · Elmont, NY |
| 56 | Tue Feb 20 | vsStars | W3-1 | 37-16-3 | 77 PTS | Madison Square Garden · Manhattan, NY |
| 57 | Thu Feb 22 | atDevils | W5-1 | 38-16-3 | 79 PTS | Prudential Center · Newark, NJ |
| 58 | Sat Feb 24 | atFlyers | W2-1 | 39-16-3 | 81 PTS | Wells Fargo Center · Philadelphia, PA |
| 59 | Sun Feb 25 | atJackets | L2-4 | 39-17-3 | 81 PTS | Nationwide Arena · Columbus, OH |
| 60 | Wed Feb 28 | vsJackets | W4-1 | 40-17-3 | 83 PTS | Madison Square Garden · Manhattan, NY |
| 61 | Sat Mar 2 | atMaple Leafs | L3-4 (SO) | 40-17-4 | 84 PTS | Scotiabank Arena · Toronto, ON |
| 62 | Mon Mar 4 | vsPanthers | L2-4 | 40-18-4 | 84 PTS | Madison Square Garden · Manhattan, NY |
| 63 | Sat Mar 9 | vsBlues | W4-0 | 41-18-4 | 86 PTS | Madison Square Garden · Manhattan, NY |
| 64 | Mon Mar 11 | vsDevils | W3-1 | 42-18-4 | 88 PTS | Madison Square Garden · Manhattan, NY |
| 65 | Tue Mar 12 | atHurricanes | W1-0 | 43-18-4 | 90 PTS | PNC Arena · Raleigh, NC |
| 66 | Thu Mar 14 | atLightning | L3-6 | 43-19-4 | 90 PTS | AMALIE Arena · Tampa, FL |
| 67 | Sat Mar 16 | atPenguins | W7-4 | 44-19-4 | 92 PTS | PPG Paints Arena · Pittsburgh, PA |
| 68 | Sun Mar 17 | vsIslanders | W5-2 | 45-19-4 | 94 PTS | Madison Square Garden · Manhattan, NY |
| 69 | Tue Mar 19 | vsJets | L2-4 | 45-20-4 | 94 PTS | Madison Square Garden · Manhattan, NY |
| 70 | Thu Mar 21 | atBruins | W5-2 | 46-20-4 | 96 PTS | TD Garden · Boston, MA |
| 71 | Sat Mar 23 | vsPanthers | W4-3 (SO) | 47-20-4 | 98 PTS | Madison Square Garden · Manhattan, NY |
| 72 | Tue Mar 26 | vsFlyers | W6-5 (OT) | 48-20-4 | 100 PTS | Madison Square Garden · Manhattan, NY |
| 73 | Thu Mar 28 | atAvalanche | W3-2 (SO) | 49-20-4 | 102 PTS | Ball Arena · Denver, CO |
| 74 | Sat Mar 30 | atCoyotes | W8-5 | 50-20-4 | 104 PTS | Mullett Arena · Tempe, AZ |
| 75 | Mon Apr 1 | vsPenguins | L2-5 | 50-21-4 | 104 PTS | Madison Square Garden · Manhattan, NY |
| 76 | Wed Apr 3 | vsDevils | W4-3 | 51-21-4 | 106 PTS | Madison Square Garden · Manhattan, NY |
| 77 | Fri Apr 5 | atRed Wings | W4-3 | 52-21-4 | 108 PTS | Little Caesars Arena · Detroit, MI |
| 78 | Sun Apr 7 | vsCanadiens | W5-2 | 53-21-4 | 110 PTS | Madison Square Garden · Manhattan, NY |
| 79 | Tue Apr 9 | atIslanders | L2-4 | 53-22-4 | 110 PTS | UBS Arena · Elmont, NY |
| 80 | Thu Apr 11 | vsFlyers | L1-4 | 53-23-4 | 110 PTS | Madison Square Garden · Manhattan, NY |
| 81 | Sat Apr 13 | vsIslanders | W3-2 (SO) | 54-23-4 | 112 PTS | Madison Square Garden · Manhattan, NY |
| 82 | Mon Apr 15 | vsSenators | W4-0 | 55-23-4 | 114 PTS | Madison Square Garden · Manhattan, NY |
| 1 | Sun Apr 21 | vsCapitals | W4-1 | 1-0 | 1.000 | Madison Square Garden · Manhattan, NY |
| 2 | Tue Apr 23 | vsCapitals | W4-3 | 2-0 | 1.000 | Madison Square Garden · Manhattan, NY |
| 3 | Fri Apr 26 | atCapitals | W3-1 | 3-0 | 1.000 | Capital One Arena · Washington, D.C. |
| 4 | Sun Apr 28 | atCapitals | W4-2 | 4-0 | 1.000 | Capital One Arena · Washington, D.C. |
| 1 | Sun May 5 | vsHurricanes | W4-3 | 1-0 | 1.000 | Madison Square Garden · Manhattan, NY |
| 2 | Tue May 7 | vsHurricanes | W4-3 (OT) | 2-0 | 1.000 | Madison Square Garden · Manhattan, NY |
| 3 | Thu May 9 | atHurricanes | W3-2 (OT) | 3-0 | 1.000 | PNC Arena · Raleigh, NC |
| 4 | Sat May 11 | atHurricanes | L3-4 | 3-1 | .750 | PNC Arena · Raleigh, NC |
| 5 | Mon May 13 | vsHurricanes | L1-4 | 3-2 | .600 | Madison Square Garden · Manhattan, NY |
| 6 | Thu May 16 | atHurricanes | W5-3 | 4-2 | .667 | PNC Arena · Raleigh, NC |
| 1 | Wed May 22 | vsPanthers | L0-3 | 0-1 | .000 | Madison Square Garden · Manhattan, NY |
| 2 | Fri May 24 | vsPanthers | W2-1 (OT) | 1-1 | .500 | Madison Square Garden · Manhattan, NY |
| 3 | Sun May 26 | atPanthers | W5-4 (OT) | 2-1 | .667 | Amerant Bank Arena · Sunrise, FL |
| 4 | Tue May 28 | atPanthers | L2-3 (OT) | 2-2 | .500 | Amerant Bank Arena · Sunrise, FL |
| 5 | Thu May 30 | vsPanthers | L2-3 | 2-3 | .400 | Madison Square Garden · Manhattan, NY |
| 6 | Sat Jun 1 | atPanthers | L1-2 | 2-4 | .333 | Amerant Bank Arena · Sunrise, FL |
