| 1 | Tue Oct 10 | vs Blackhawks | L2-4 | 0-1-0 | 0 PTS | PPG Paints Arena · Pittsburgh, PA |
| 2 | Fri Oct 13 | atCapitals | W4-0 | 1-1-0 | 2 PTS | Capital One Arena · Washington, D.C. |
| 3 | Sat Oct 14 | vsFlames | W5-2 | 2-1-0 | 4 PTS | PPG Paints Arena · Pittsburgh, PA |
| 4 | Wed Oct 18 | atRed Wings | L3-6 | 2-2-0 | 4 PTS | Little Caesars Arena · Detroit, MI |
| 5 | Sat Oct 21 | atBlues | L2-4 | 2-3-0 | 4 PTS | Enterprise Center · St. Louis, MO |
| 6 | Tue Oct 24 | vsStars | L1-4 | 2-4-0 | 4 PTS | PPG Paints Arena · Pittsburgh, PA |
| 7 | Thu Oct 26 | vsAvalanche | W4-0 | 3-4-0 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 8 | Sat Oct 28 | vsSenators | L2-5 | 3-5-0 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 9 | Mon Oct 30 | vsDucks | L3-4 | 3-6-0 | 6 PTS | PPG Paints Arena · Pittsburgh, PA |
| 10 | Sat Nov 4 | atSharks | W10-2 | 4-6-0 | 8 PTS | SAP Center · San Jose, CA |
| 11 | Tue Nov 7 | atDucks | W2-0 | 5-6-0 | 10 PTS | Honda Center · Anaheim, CA |
| 12 | Thu Nov 9 | atKings | W4-3 (OT) | 6-6-0 | 12 PTS | Crypto.com Arena · Los Angeles, CA |
| 13 | Sat Nov 11 | vsSabres | W4-0 | 7-6-0 | 14 PTS | PPG Paints Arena · Pittsburgh, PA |
| 14 | Tue Nov 14 | atJackets | W5-3 | 8-6-0 | 16 PTS | Nationwide Arena · Columbus, OH |
| 15 | Thu Nov 16 | vsDevils | L2-5 | 8-7-0 | 16 PTS | PPG Paints Arena · Pittsburgh, PA |
| 16 | Sat Nov 18 | atHurricanes | L2-4 | 8-8-0 | 16 PTS | PNC Arena · Raleigh, NC |
| 17 | Sun Nov 19 | vsKnights | W3-0 | 9-8-0 | 18 PTS | PPG Paints Arena · Pittsburgh, PA |
| 18 | Wed Nov 22 | vsRangers | L0-1 | 9-9-0 | 18 PTS | PPG Paints Arena · Pittsburgh, PA |
| 19 | Fri Nov 24 | atSabres | L2-3 | 9-10-0 | 18 PTS | KeyBank Center · Buffalo, NY |
| 20 | Sat Nov 25 | vsMaple Leafs | W3-2 | 10-10-0 | 20 PTS | PPG Paints Arena · Pittsburgh, PA |
| 21 | Tue Nov 28 | atPredators | L2-3 (OT) | 10-10-1 | 21 PTS | Bridgestone Arena · Nashville, TN |
| 22 | Thu Nov 30 | atLightning | W4-2 | 11-10-1 | 23 PTS | AMALIE Arena · Tampa, FL |
| 23 | Sat Dec 2 | vsFlyers | L3-4 (SO) | 11-10-2 | 24 PTS | PPG Paints Arena · Pittsburgh, PA |
| 24 | Mon Dec 4 | atFlyers | L1-2 (OT) | 11-10-3 | 25 PTS | Wells Fargo Center · Philadelphia, PA |
| 25 | Wed Dec 6 | atLightning | L1-3 | 11-11-3 | 25 PTS | AMALIE Arena · Tampa, FL |
| 26 | Fri Dec 8 | atPanthers | L1-3 | 11-12-3 | 25 PTS | Amerant Bank Arena · Sunrise, FL |
| 27 | Tue Dec 12 | vsCoyotes | W4-2 | 12-12-3 | 27 PTS | PPG Paints Arena · Pittsburgh, PA |
| 28 | Wed Dec 13 | atCanadiens | W4-3 (SO) | 13-12-3 | 29 PTS | Bell Centre · Montreal, QC |
| 29 | Sat Dec 16 | atMaple Leafs | L0-7 | 13-13-3 | 29 PTS | Scotiabank Arena · Toronto, ON |
| 30 | Mon Dec 18 | vsWild | W4-3 | 14-13-3 | 31 PTS | PPG Paints Arena · Pittsburgh, PA |
| 31 | Thu Dec 21 | vsHurricanes | W2-1 (SO) | 15-13-3 | 33 PTS | PPG Paints Arena · Pittsburgh, PA |
| 32 | Sat Dec 23 | atSenators | L4-5 (OT) | 15-13-4 | 34 PTS | Canadian Tire Centre · Ottawa, ON |
| 33 | Wed Dec 27 | atIslanders | W7-0 | 16-13-4 | 36 PTS | UBS Arena · Elmont, NY |
| 34 | Sat Dec 30 | vsBlues | W4-2 | 17-13-4 | 38 PTS | PPG Paints Arena · Pittsburgh, PA |
| 35 | Sun Dec 31 | vsIslanders | W3-1 | 18-13-4 | 40 PTS | PPG Paints Arena · Pittsburgh, PA |
| 36 | Tue Jan 2 | vsCapitals | L3-4 | 18-14-4 | 40 PTS | PPG Paints Arena · Pittsburgh, PA |
| 37 | Thu Jan 4 | atBruins | W6-5 | 19-14-4 | 42 PTS | TD Garden · Boston, MA |
| 38 | Sat Jan 6 | vsSabres | L1-3 | 19-15-4 | 42 PTS | PPG Paints Arena · Pittsburgh, PA |
| 39 | Mon Jan 8 | atFlyers | W4-1 | 20-15-4 | 44 PTS | Wells Fargo Center · Philadelphia, PA |
| 40 | Thu Jan 11 | vsCanucks | L3-4 (OT) | 20-15-5 | 45 PTS | PPG Paints Arena · Pittsburgh, PA |
| 41 | Sat Jan 13 | atHurricanes | L2-3 (OT) | 20-15-6 | 46 PTS | PNC Arena · Raleigh, NC |
| 42 | Mon Jan 15 | vsKraken | W3-0 | 21-15-6 | 48 PTS | PPG Paints Arena · Pittsburgh, PA |
| 43 | Sat Jan 20 | atKnights | L2-3 | 21-16-6 | 48 PTS | T-Mobile Arena · Las Vegas, NV |
| 44 | Mon Jan 22 | atCoyotes | L2-5 | 21-17-6 | 48 PTS | Mullett Arena · Tempe, AZ |
| 45 | Fri Jan 26 | vsPanthers | L2-3 (SO) | 21-17-7 | 49 PTS | PPG Paints Arena · Pittsburgh, PA |
| 46 | Sat Jan 27 | vsCanadiens | W3-2 (OT) | 22-17-7 | 51 PTS | PPG Paints Arena · Pittsburgh, PA |
| 47 | Tue Feb 6 | vsJets | W3-0 | 23-17-7 | 53 PTS | PPG Paints Arena · Pittsburgh, PA |
| 48 | Fri Feb 9 | atWild | L2-3 | 23-18-7 | 53 PTS | Xcel Energy Center · St. Paul, MN |
| 49 | Sat Feb 10 | atJets | L1-2 | 23-19-7 | 53 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 50 | Wed Feb 14 | vsPanthers | L2-5 | 23-20-7 | 53 PTS | PPG Paints Arena · Pittsburgh, PA |
| 51 | Thu Feb 15 | atBlackhawks | W4-1 | 24-20-7 | 55 PTS | United Center · Chicago, IL |
| 52 | Sun Feb 18 | vsKings | L1-2 | 24-21-7 | 55 PTS | PPG Paints Arena · Pittsburgh, PA |
| 53 | Tue Feb 20 | vsIslanders | L4-5 (OT) | 24-21-8 | 56 PTS | PPG Paints Arena · Pittsburgh, PA |
| 54 | Thu Feb 22 | vsCanadiens | W4-1 | 25-21-8 | 58 PTS | PPG Paints Arena · Pittsburgh, PA |
| 55 | Sun Feb 25 | vsFlyers | W7-6 | 26-21-8 | 60 PTS | PPG Paints Arena · Pittsburgh, PA |
| 56 | Tue Feb 27 | atCanucks | W4-3 (OT) | 27-21-8 | 62 PTS | Rogers Arena · Vancouver, British Columbia |
| 57 | Thu Feb 29 | atKraken | L0-2 | 27-22-8 | 62 PTS | Climate Pledge Arena · Seattle, WA |
| 58 | Sat Mar 2 | atFlames | L3-4 | 27-23-8 | 62 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 59 | Sun Mar 3 | atOilers | L1-6 | 27-24-8 | 62 PTS | Rogers Place · Edmonton, AB |
| 60 | Tue Mar 5 | vsJackets | W5-3 | 28-24-8 | 64 PTS | PPG Paints Arena · Pittsburgh, PA |
| 61 | Thu Mar 7 | vsCapitals | L0-6 | 28-25-8 | 64 PTS | PPG Paints Arena · Pittsburgh, PA |
| 62 | Sat Mar 9 | atBruins | L1-5 | 28-26-8 | 64 PTS | TD Garden · Boston, MA |
| 63 | Sun Mar 10 | vsOilers | L0-4 | 28-27-8 | 64 PTS | PPG Paints Arena · Pittsburgh, PA |
| 64 | Tue Mar 12 | atSenators | L1-2 (OT) | 28-27-9 | 65 PTS | Canadian Tire Centre · Ottawa, ON |
| 65 | Thu Mar 14 | vsSharks | W6-3 | 29-27-9 | 67 PTS | PPG Paints Arena · Pittsburgh, PA |
| 66 | Sat Mar 16 | vsRangers | L4-7 | 29-28-9 | 67 PTS | PPG Paints Arena · Pittsburgh, PA |
| 67 | Sun Mar 17 | vsRed Wings | W6-3 | 30-28-9 | 69 PTS | PPG Paints Arena · Pittsburgh, PA |
| 68 | Tue Mar 19 | atDevils | L2-5 | 30-29-9 | 69 PTS | Prudential Center · Newark, NJ |
| 69 | Fri Mar 22 | atStars | L2-4 | 30-30-9 | 69 PTS | American Airlines Center · Dallas, TX |
| 70 | Sun Mar 24 | atAvalanche | L4-5 (OT) | 30-30-10 | 70 PTS | Ball Arena · Denver, CO |
| 71 | Tue Mar 26 | vsHurricanes | W4-1 | 31-30-10 | 72 PTS | PPG Paints Arena · Pittsburgh, PA |
| 72 | Thu Mar 28 | vsJackets | W3-2 | 32-30-10 | 74 PTS | PPG Paints Arena · Pittsburgh, PA |
| 73 | Sat Mar 30 | atJackets | L3-4 (SO) | 32-30-11 | 75 PTS | Nationwide Arena · Columbus, OH |
| 74 | Mon Apr 1 | atRangers | W5-2 | 33-30-11 | 77 PTS | Madison Square Garden · Manhattan, NY |
| 75 | Tue Apr 2 | atDevils | W6-3 | 34-30-11 | 79 PTS | Prudential Center · Newark, NJ |
| 76 | Thu Apr 4 | atCapitals | W4-1 | 35-30-11 | 81 PTS | Capital One Arena · Washington, D.C. |
| 77 | Sat Apr 6 | vsLightning | W5-4 | 36-30-11 | 83 PTS | PPG Paints Arena · Pittsburgh, PA |
| 78 | Mon Apr 8 | atMaple Leafs | L2-3 (OT) | 36-30-12 | 84 PTS | Scotiabank Arena · Toronto, ON |
| 79 | Thu Apr 11 | vsRed Wings | W6-5 (OT) | 37-30-12 | 86 PTS | PPG Paints Arena · Pittsburgh, PA |
| 80 | Sat Apr 13 | vsBruins | L4-6 | 37-31-12 | 86 PTS | PPG Paints Arena · Pittsburgh, PA |
| 81 | Mon Apr 15 | vsPredators | W4-2 | 38-31-12 | 88 PTS | PPG Paints Arena · Pittsburgh, PA |
| 82 | Wed Apr 17 | atIslanders | L4-5 | 38-32-12 | 88 PTS | UBS Arena · Elmont, NY |
